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Nucleolar organizer regions (NORs) and myoepitheliomas: a comparison with DNA content and clinical course

Published online by Cambridge University Press:  29 June 2007

Rosario Carrillo ,
Adel K. El-Naggar ,
Mario A. Luna ,
Jose L. Rodriguez-Peralto  and
John G. Batsakis
Rosario Carrillo
Affiliation:
Houston, Texas
Adel K. El-Naggar
Affiliation:
Houston, Texas
Mario A. Luna
Affiliation:
Houston, Texas
Jose L. Rodriguez-Peralto
Affiliation:
Houston, Texas
John G. Batsakis*
Affiliation:
Houston, Texas
*
John G. Batsakis, M.D., Department of Pathology, Box 85, M.D. Anderson Cancer Centre, 1515 Holcombe Blvd., Houston, TX 77030.
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Abstract

Nucleolar organizer regions (NOR) were studied in 15 salivary gland myoepitheliomas by an argyrophilic staining technic (AgNOR). The AgNOR data were then compared with flow cytometric DNA content of the neoplasms and also with selected clinicopathologic parameters. We conclude that AgNOR's: (1) do not correlate well with DNA cytometric indices and (2) at best, provide redundant information.

Keywords

Nucleolus organizer regionSalivary gland neoplasms
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 106 , Issue 7 , July 1992 , pp. 616 - 620
Copyright
Copyright © JLO (1984) Limited 1992

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References

Ayres, J. G., Crocker, J. G., Skilbeck, N. Q. (1988) Differentiation of malignant from normal and reactive mesothelial cells by the argyrophil technique for nucleolar organizer region associated proteins. Thorax, 43: 366–370.CrossRefGoogle Scholar
Baisch, H., Gö hde, W., Linden, W. A. (1975) Analysis of PCP-data to determine the fraction of cells in the various phases of cell cycle. Radiation and Environmental Biophysics, 12: 31–39.CrossRefGoogle ScholarPubMed
Barnes, L., Appel, B. N., Perez, H., El-Attar, A. M. (1982) Myoepithelioma of the head and neck: case reports and review. Journal of Surgical Oncology, 28: 21–28.CrossRefGoogle Scholar
Batsakis, J. G. (1985) Myoepithelioma. Annals of Otology, Rhinology and Laryngology, 94: 523–524.CrossRefGoogle ScholarPubMed
Bockmiihl, U., Theissig, E., Dimmer, V., Kunze, K. D. (1991) The impact of nucleolar organizer regions for the lymph node spread and prognosis of invasive ductal mammary carcinoma. Pathology Research and Practice, 187: 437–443.CrossRefGoogle Scholar
Chomette, G. P., Auriol, M., Labrousse, E., Vaillant, J. M. (1991) Mucoepidermoid tumours of salivary glands: histoprognostic value of NORs stained with AgNOR technique. Journal of Oral Pathology and Medicine, 20: 130–132.CrossRefGoogle ScholarPubMed
Cibull, M. L., Heryet, A., Gatter, K. C, Mason, D. Y. (1989) The utility of Ki-67 immunostaining, nucleolar organizer region counting and morphology in the assessment of follicular lymphomas. Journal of Pathology, 158: 189–193.CrossRefGoogle Scholar
Contractor, H., Ruschoff, J., Hanisch, T., Ulshofer, B., Neumann, K., Schultze- Seemann, W., Thomas, C. (1991) Silver-stained structures in prostatic carcinoma: Evaluation of diagnostic and prognostic relevance by automated image analysis. Urologic Internationalis, 46: 9–14.CrossRefGoogle ScholarPubMed
Crissman, J. D., Wirman, J. A., Harris, A. (1977) Malignant myoepithelioma of the parotid gland. Cancer, 40: 3042–3049.3.0.CO;2-N>CrossRefGoogle ScholarPubMed
Crocker, J. (1988) Nucleolar organizer regions. Current Topics in Pathology, 82: 91–149.CrossRefGoogle Scholar
Crocker, J., MaCartney, J. C, Smith, P. J. (1988) Correlation between DNA flow cytometric and nucleolar organizer region data in non-Hodgkin's lymphomas. Journal of Pathology, 154: 151–156.CrossRefGoogle ScholarPubMed
Crocker, J., Nar, P. (1987). Nucleolar organizer regions in lymphomas. Journal of Pathology, 151: 111–118.CrossRefGoogle ScholarPubMed
Crocker, J., Skilbeck, N. (1987) Nucleolar organizer region associated proteins in cutaneous melanotic lesions: a quantitative study. Journal of Clinical Pathology, 40: 885–889.CrossRefGoogle Scholar
Delahunt, B., Ribas, J. L., Nacey, J. N., Bethwaite, P. B. (1991) Nucleolar organizer regions and prognosis in renal cell carcinoma. Journal of Pathology, 163: 31–37.CrossRefGoogle ScholarPubMed
Derenzini, M., Pession, A., Trere, D. (1990) Quantity of nucleolar silver-stained proteins is related to proliferating activity in cancer cells. Laboratory Investigation, 63: 137–140.Google ScholarPubMed
Dervan, P. A., Gilmartin, L. G., Loftus, B. M., Carney, D. N. (1989) Breast carcinoma kinetics: argyrophilic nucleolar organizer region counts correlate with K67 scores. American Journal of Clinical Pathology, 92: 401–407.CrossRefGoogle Scholar
Dressier, L. G., Bartow, S. A. (1989) DNA flow cytometry in solid tumours: practical aspects and clinical application. Seminars in Diagnostic Pathology, 6: 55–82.Google Scholar
El-Naggar, A. K., Batsakis, J. G., Luna, M. A., Goepfert, H., Tortoledo, M. E. (1989). DNA content and proliferative activity of myoepitheliomas. Journal of Laryngology and Otology, 103: 1192–1197.CrossRefGoogle ScholarPubMed
Giri, D. D., Nottingham, J. E, Lawry, J., Dundas, S. A. C, Underwood, J. C. E. (1989) Silver-binding nucleolar organizer regions (AgNORs) in benign and malignant breast lesions: correlations with ploidy and growth phase by flow cytometry. Journal of Pathology, 157: 307–313.CrossRefGoogle Scholar
Hall, P. A., Crocker, J., Watts, A., Stansfeld, A. G. (1988) A comparison of nucleolar organizer region staining and Ki-67 immunostaining in non-Hodgkin's lymphoma. Histopathology, 12: 373–381.CrossRefGoogle ScholarPubMed
Hedley, D. W., Friedlander, M. L., Taylor, I. W., Rugg, C. A., Mus Musgrove, E. A. (1983) Method for analysis of cellular DNA content of paraffin-embedded pathological material using flow cytometry. Journal of Histochmistry and Cytochemistry, 31: 1333–1335.CrossRefGoogle ScholarPubMed
Howat, A. J., Giri, D. D., Cotton, D. W. K., Slater, D. N. (1989) Nucleolar organizer regions in spitz nevi and malignant melanomas. Cancer, 63: 474–478.3.0.CO;2-3>CrossRefGoogle ScholarPubMed
Kram, N., Nessim, S., Geller, S. A. (1989) a study of colonic adenocarcinoma, with comparison of histopathology, DNA flow cytometric data, and number of nucleolar organizer regions (NORs). Modern Pathology, 2: 468–472.Google ScholarPubMed
Lloyd, S. N., Johnson, C. P., Brown, I. L., Kirk, D. (1991) Nucleolar organizer regions in benign and malignant prostatic disease. Histopathology, 18: 449–452.CrossRefGoogle ScholarPubMed
Matsumara, K., Sasaki, K., Tsuji, T, Shinozaki, E (1989) The nucleolar organizer regions associated protein (Ag-NORs) in salivary gland tumours. International Journal of Oral and Maxillofacial Surgery, 18: 76–78.CrossRefGoogle Scholar
McLemore, D., Lord, B. A. (1991) Argyrophilic nucleolar organizer regions: an improved technique for visualization. Journal of Histotechnology 14: 187–189.CrossRefGoogle Scholar
Morgan, D. W., Crocker, J., Watts, A., Shenoi, P. M. (1988) Salivary gland tumours studied by means of the AgNOR technique. Histopathology, 13: 553–559.CrossRefGoogle ScholarPubMed
Öfner, D., Totsch, M., Sandbichler, P., Hallbrucker, C. H. R., Margreiter, R., Mikuz, G., Schmid, K. W. (1990) Silver stained nucleolar organizer region proteins (Ag-NORs)as a predictor of prognosis in colonic cancer. Journal of Pathology, 162: 43–49.CrossRefGoogle ScholarPubMed
Pich, A., Valente, L., Azzoni, L., Stramignoni, A. (1991) Argyrophilic nucleolar organizer region counts and Ki-67 scores in human renal cell carcinoma. Pathology Research and Practice, 187: 482–486.CrossRefGoogle ScholarPubMed
Rosa, J., Mehta, A., Filipe, M. I. (1990) Nucleolar organizer regions in gastric carcinoma and its precursor stages. Histopathology, 16: 265–269.CrossRefGoogle ScholarPubMed
Rümschoff, J., Neumann, K., Contractor, H., Plate, K., Thomas, C. (1990 a) Assessment of nucleolar organizer regions by automatic image analysis in breast cancer: correlation with DNA content, proliferation rate, receptor status and histopathological grading. Journal of Cancer Research and Clinical Oncology, 116: 480–485.CrossRefGoogle Scholar
Rü schoff, J., Bittinger, A., Neumann, K., Schmitz- Moorman, P. (1990 b) Prognostic significance of nucleolar organizing regions (NORs) in carcinomas of the sigmoid colon and rectum. Pathology Research and Practice, 186: 85–91.CrossRefGoogle Scholar
Sciubba, J. J., Brannon, R. B. (1982) Myoepithelioma of salivary glands: Report of 23 cases. Cancer, 49: 562–572.3.0.CO;2-6>CrossRefGoogle ScholarPubMed
Soomro, I. N., Whimster, W. E (1990) Growth fraction in lung tumours determined by Ki-67 immunostaining and comparison with AgNOR scores. Journal of Pathology, 162: 217–222.CrossRefGoogle Scholar
Troster, H., Sring, H., Meissner, B., Schultz, P., Oudt, P., Trendelenburg, M. E (1985) Structural organizations of an active, chromosomal nucleolar organizer region (NOR) identified by light microscopy and subsequent TEM and STEM electron. Chromosoma, 91: 151–163.CrossRefGoogle ScholarPubMed
Van Heerden, W. E P., Raubenheimer, E. J. (1991) Evaluation of the nucleolar organizer region associated proteins in minor salivary gland tumors. Journal of Oral Pathology and Medicine, 20: 291–295.CrossRefGoogle ScholarPubMed