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A new technique using cultured epithelial sheets for the management of epistaxis associated with hereditary haemorrhagic telangiectasia

Published online by Cambridge University Press:  29 June 2007

Catherine M. Milton ,
J. C. Shotton ,
D. J. Premachandran ,
Barbara M. Woodward ,
J. W. Fabre  and
R. J. Sergeant
Catherine M. Milton*
Affiliation:
Department of Otolaryngology Kent and Sussex Hospital, Tunbridge Wells
J. C. Shotton
Affiliation:
Department of Otolaryngology Kent and Sussex Hospital, Tunbridge Wells
D. J. Premachandran
Affiliation:
The Blond Mclndoe Centre for Medical Research, Queen Victoria Hospital, East Grinstead
Barbara M. Woodward
Affiliation:
Department of Otolaryngology, James Paget Hospital, Great Yarmouth
J. W. Fabre
Affiliation:
Department of Otolaryngology, James Paget Hospital, Great Yarmouth
R. J. Sergeant
Affiliation:
Department of Otolaryngology Kent and Sussex Hospital, Tunbridge Wells
*
Miss Catherine M. Milton, Department of Otolaryngology, Kent and Sussex Hospital, Tunbridge Wells, Kent TN4 8AT
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Abstract

A new technique for the treatment of severe epistaxis associated with hereditary haemorrhagic telangiectasia is described. The nasal septum and inferior turbinates, surgically denuded of respiratory epithelium, were grafted using autografts of cultured epithelial sheets derived from buccal epithelium. All patients upon whom this technique has been used have shown considerable lessening in the frequency and severity of their epistaxes although two patients received grafts on two occasions, in each case approximately three months apart. It is postulated that a nasal lining of stratified squamous epithelium is likely to be more resistant to trauma than the normal respiratory type, and this is supported by the observation that bleeds very seldom occur from the oral cavity in this syndrome.

Keywords

EpistaxisTelangiectasiahereditary haemorrhagicEpithelial cellsautologousculturedTransplantationautologous
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 107 , Issue 6 , June 1993 , pp. 510 - 513
Copyright
Copyright © JLO (1984) Limited 1993

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