Hostname: page-component-cd9895bd7-8ctnn Total loading time: 0 Render date: 2024-12-23T19:02:51.928Z Has data issue: false hasContentIssue false

Nebulised N-acetylcysteine used in acute tracheostoma obstruction

Published online by Cambridge University Press:  02 October 2014

A Patel*
Affiliation:
ENT Department, Lewisham Hospital, London, UK
C Theokli
Affiliation:
ENT Department, Lewisham Hospital, London, UK
*
Address for correspondence: Dr Ankit Patel, 9 Elstree Hill, Bromley, Kent BR1 4JE, UK Fax: 020 8333 333 E-mail: [email protected]

Abstract

Background:

Patients with laryngectomy tracheostomas are at risk of developing acute airway obstruction due to mucous crusting. Current management relies on saline nebulisers, followed by suction and manual evacuation to remove the obstruction. This paper describes the first reported case of using N-acetylcysteine nebulisers in addition to saline to adequately soften the mucous plugs in order to facilitate removal.

Case report:

A 68-year-old female attended the emergency department with a partial obstruction of her laryngectomy tracheostoma as a result of mucous crusting. Saline nebulisers did not provide adequate softening to allow the obstructing mucous plugs to be removed. N-acetylcysteine nebulisers were used to further soften the mucous plugs which successfully resulted in their removal.

Conclusion:

N-acetylcysteine nebulisers can be used to assist in the removal of mucous plugs in saline-resistant cases.

Type
Clinical Records
Copyright
Copyright © JLO (1984) Limited 2014 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1Jay, S, Ruddy, J, Cullen, RJ. Laryngectomy: the patient's view. J Laryngol Otol 1991;105:934–8Google Scholar
2Lewarski, J. Long-term care of the patient with a tracheostomy. Respir Care 2005;50:534–7Google ScholarPubMed
3Ganly, I, Patel, S, Matsuo, J, Singh, B, Kraus, D, Boyle, J et al. Postoperative complications of salvage total laryngectomy. Cancer 2005;103:2073–81Google Scholar
4Samuni, Y, Goldstein, S, Dean, O, Berk, M. The chemistry and biological activities of N-acetylcysteine. Biochim Biophys Acta 2013;1830:4117–29CrossRefGoogle ScholarPubMed
5N-acetylcysteine. Altern Med Rev 2000;5:467–71Google Scholar
6Zimet, I. Acetylcholine: a drug that is much more than a mucokinetic. Biomed Pharmacother 1988;42:513–20Google Scholar
7Nash, EF, Stephenson, A, Ratjen, F, Tullis, E. Nebulized and oral thiol derivatives for pulmonary disease in cystic fibrosis. Cochrane Database Syst Rev 2009;(1):CD007168CrossRefGoogle Scholar
8Millar, AB, Parvia, D, Agnew, JE, Lopez-Vidriero, MT, Lauque, D, Clarke, SW. Effect of oral N-acetylcysteine on mucus clearance. Br J Dis Chest 1985;79:262–6CrossRefGoogle ScholarPubMed
9British Thoracic Society Research Committee. Oral N-acetylcysteine and exacerbation rates in patients with chronic bronchitis and severe airways obstruction. Thorax 1985;40:832–5Google Scholar