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Nasal decongestant effect of oxymetazoline in the common cold: An objective dose-response study in 106 patients

Published online by Cambridge University Press:  29 June 2007

Anders Åkerland ,
Thorsten Klint ,
Lars Olén  and
Hans Rundcrantz
Anders Åkerland
Affiliation:
From the Department of Otorinolaryngology, Central Hospital, Sköevde
Thorsten Klint
Affiliation:
Department of Clinical Research, AB Draco, Lund, Sweden
Lars Olén
Affiliation:
From the Department of Otorinolaryngology, Central Hospital, Sköevde
Hans Rundcrantz*
Affiliation:
From the Department of Otorinolaryngology, Central Hospital, Sköevde
*
Dr. Hans Rundcrantz, M.D., PhD. Department of Otorhinolaryngology, Central Hospital, S-541 85 Skoevde, Sweden.
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Abstract

Oxymetazoline has been used as decongesting nosedrops for more than 25 years but so far no objective does-response study of the drug has been published. In this double-blind clinical trial the decongestant effect on the nasal mucosa by the doses and concentrations traditionally used of oxymetazoline were studied.

In 106 men with acute infectious rhinitis, a significant dose-response relationship was found when the decongestant effect was measured objectively by anterior rhinomanometry and subjectively by symptom scores.

The concentration and volumes of the drug recommended from clinical experience seem to be adequate.

Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 103 , Issue 8 , August 1989 , pp. 743 - 746
Copyright
Copyright © JLO (1984) Limited 1989

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