Hostname: page-component-586b7cd67f-r5fsc Total loading time: 0 Render date: 2024-11-22T16:33:29.908Z Has data issue: false hasContentIssue false
  • English
  • Français

Nasal chondromesenchymal hamartoma: an update

Published online by Cambridge University Press:  23 August 2021

T F C Saunders ,
H Bruijnzeel ,
S Ahmed ,
M Paruleka  and
A-L McDermott
T F C Saunders*
Affiliation:
Department of Otolaryngology, Birmingham Children's Hospital, UK
H Bruijnzeel
Affiliation:
Department of Otorhinolaryngology and Head and Neck Surgery, UMC Utrecht, The Netherlands Brain Center Rudolf Magnus, Utrecht, The Netherlands
S Ahmed
Affiliation:
Department of Skull base Surgery, University Hospital Birmingham, UK
M Paruleka
Affiliation:
Department of Ophthalmology, Birmingham Children's Hospital, UK
A-L McDermott
Affiliation:
Department of Otolaryngology, Birmingham Children's Hospital, UK
*
Author for correspondence: Mr T F C Saunders, Department of Otolaryngology (ENT), Birmingham Children's Hospital, Steelhouse Lane, BirminghamB4 6NH, UK E-mail: [email protected]
Get access Rights & Permissions [Opens in a new window]

Abstract

Objective

Nasal chondromesenchymal hamartoma is a rare pathology that can present with a myriad of symptoms to ENT, maxillofacial and ophthalmology departments. This study reviewed the literature on nasal chondromesenchymal hamartoma as well as adding three new cases to the reported literature.

Method

This study was an up-to-date review of the world literature with the addition of three new cases to provide the most comprehensive review to date.

Results

A total of 56 patients with nasal chondromesenchymal hamartoma were identified, ranging from children to adults. Nasal symptoms and ocular symptoms were most common, and surgical resection was the most frequent treatment modality.

Conclusion

This study advocates for increased awareness of the condition associations for nasal chondromesenchymal hamartoma, multi-specialty treatment and the role for the ENT surgeon in treatment of the condition.

Keywords

EndoscopyParanasal SinusesOtolaryngology
Type
Review Article
Information
The Journal of Laryngology & Otology , Volume 136 , Issue 12 , December 2022 , pp. 1140 - 1147
Copyright
Copyright © The Author(s), 2021. Published by Cambridge University Press on behalf of J.L.O. (1984) LIMITED

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Footnotes

Mr T F C Saunders takes responsibility for the integrity of the content of the paper

References

McDermott, MB, Ponder, TB, Dehner, LP. Nasal chondromesenchymal hamartoma: a2 upper respiratory tract analogue of the chest wall mesenchymal hamartoma. Am J Surg Pathol 1998;4:425–33CrossRefGoogle Scholar
Schultz, KA, Yang, J, Doros, L, Williams, GM, Harris, A, Stewart, DR et al. Pleuropulmonary blastoma familial tumour predisposition syndrome: a unique constellation of neoplastic conditions. Pathology Case Rev 2014;19:90–100CrossRefGoogle ScholarPubMed
Moher, D, Liberati, A, Tetzlaff, J, Altman, DG, Group, P. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. J Clin Epidemiol 2009;62:1006–12CrossRefGoogle ScholarPubMed
Mirchia, K, Naous, R. Nasal chondromesenchymal hamartoma: rare case report in an elderly patient and brief review of literature. Case Rep Pathol 2018;5971786Google Scholar
Kato, K, Ijiri, R, Tanaka, Y, Hara, M, Sekido, K. Nasal chondromesenchymal hamartoma of infancy: the first Japanese case report. Pathol Int 1999;49:731–6CrossRefGoogle ScholarPubMed
Li, G, Fan, B, Jiao, Y. Endonasal endoscopy for removing nasal chondromesenchymal hamartoma extending from the lacrimal sac region. Can J Ophthalmol 2013;48:e22–3CrossRefGoogle ScholarPubMed
Hsueh, C, Hsueh, S, Gonzalez-Crussi, F, Lee, T, Su, J. Nasal chondromesenchymal hamartoma in children: report of 2 cases with review of the literature. Arch Pathol Lab Med 2001;125:400–3.CrossRefGoogle ScholarPubMed
Kim, DW, Low, W, Billman, G, Wickersham, J, Kearns, D. Chondroid hamartoma presenting as a neonatal nasal mass. Int J Pediatr Otorhinolaryngol 1999;47:253–9CrossRefGoogle ScholarPubMed
Norman, E, Bergman, S, Trupiano, J. Nasal chondromesenchymal hamartoma: report of a case and review of the literature. Pediatr Dev Pathol 2004;7:517–20CrossRefGoogle ScholarPubMed
Eloy, PH, Nassogne, MC, Weynand, B, Rombaux, PH. Nasal chondromesenchymal hamartoma: case report. Int J Pediatric Otorhinolaryngol Extra 2011;6:300–3CrossRefGoogle Scholar
Mason, KA, Navaratnam, A, Theodorakopoulou, E, Chokkalingham, PG. Nasal chondromesenchymal hamartoma (NCMH): a systematic review of the literature with a new case report. J Otolaryngol Head Neck Surg 2015;44:28CrossRefGoogle ScholarPubMed
Priest, JR, Williams, G, Miza, W, Dehner, L, McDermott, M. Nasal chondromesenchymal hamartoma in children with pleuropulmonary blastoma--a report from the International Pleuropulmonary Blastoma Registry registry. Int J Pediatr Otorhinolaryngol 2010;74:1240–4CrossRefGoogle ScholarPubMed
Mattos, J, Early, S. Nasal chondromesenchymal hamartoma: a case report and literature review. Int J Pediatric Otorhinolaryngol 2011;6:215–19CrossRefGoogle Scholar
Tabatabaei, A, Naeimi, M, Ghanadan, AR, Ayatollahi, H. Nasal chondromesenchymal hamartoma in an adolescent: a report of case and review of literature. Iran J Otorhinolaryngol 2006;17:19–22Google Scholar
Obidan, AA, Ashoor, MM. Nasal chondromesenchymal hamartoma in an adolescent with pleuropulmonary blastoma. Saudi Med J 2014;35:876–8Google Scholar
Taku, I, Norihiko, I, Seiji, K, Kikuro, O, Hideo, I. A case of nasal chondromesenchymal hamartoma with severe orbital deviation in infants. J Jap Soc Head Neck Surg 2002;12:45–51Google Scholar
Kang Jun, HYO, Geung-Hwan, A, Young-Min, K, Hee-Jeong, C, Hye-Jeong, C. Nasal chondromesenchymal hamartoma-a case report. Korean J Pathol 2007;41:258–62Google Scholar
Yao-Lee, A, Ryan, M, Rajaram, V. Nasal chondromesenchymal hamartoma: correlation of typical MR, CT and pathological findings. Pediatr Radiol 2011;41:675–7CrossRefGoogle ScholarPubMed
Ozolek, JA, Carrau, R, Barnes, E, Hunt, J. Nasal chondromesenchymal hamartoma in older children and adults: series and immunohistochemical analysis. Arch Pathol Lab Med 2005;129:1444–50CrossRefGoogle ScholarPubMed
Li, Y, Yang, Q, Tian, X, Li, B, Li, Z. Malignant transformation of nasal chondromesenchymal hamartoma in adult: a case report and review of the literature. Histol Histopathol 2013;28:337–44Google ScholarPubMed
Li, GY, Fan, B, Jiao, YY. Endonasal endoscopy for removing nasal chondromesenchymal hamartoma extending from the lacrimal sac region. Can J Ophthalmol 2013;48:e22–3CrossRefGoogle ScholarPubMed
Zulkifli, S, Nurliza, I, Mh, SS. Nasal chondromesenchymal hamartoma in middle aged man: a rare entity. International Medical Journal 2013;20:478–80Google Scholar
Hyo-Jeong, C, Lee, S-K. Nasal Chondromesenchymal hamartoma: a case report. Korean J Pathol 1999;33:225–7Google Scholar
Low, SE, Sethi, RK, Davies, E, Stafford, JS. Nasal chondromesenchymal hamartoma in an adolescent. Histopathology 2006;49:321–3CrossRefGoogle Scholar
Johnson, C, Nagaraj, U, Esguerra, J, Wasdahl, D. Nasal chondromesenchymal hamartoma: radiographic and histopathologic analysis of a rare pediatric tumor. Pediatr Radiol 2007;37:101–4CrossRefGoogle ScholarPubMed
Finitsis, S, Giavroglou, C, Potsi, S, Constantinidis, I, Mpaltatzidis, A, Rachovitsas, D et al. Nasal chondromesenchymal hamartoma in a child. Cardiovasc Intervent Radiol 2009;32:593–7CrossRefGoogle ScholarPubMed
Xia, H, Qi, WZ, Wang, ZM. Clinicopathological observation of nasal chondromesenchymal hamartoma in infant. J Prac Oncol 2014;29:175–8Google Scholar
Silkiss, RZ, Mudvari, SS, Shetlar, D. Ophthalmologic presentation of nasal chondromesenchymal hamartoma in an infant. Ophthal Plast Reconstr Surg 2007;23:243–4CrossRefGoogle ScholarPubMed
Ganske, I, Faquin, W, Cunningham, M. Pathology Quiz Case 2. Nasal chondromesenchymal hamartoma (NCMH). Arch Otolaryngol Head Neck Surg 2009;135:945, 947–8CrossRefGoogle ScholarPubMed
Chandra, M, Venkatahalam, VP. Nasal chondromesenchymal hamartoma: a case report and review of literature. JK Practitioner 2014;19:53–9Google Scholar
Wang, T, Li, W, Wu, X, Li, Q, Cui, Y, Chu, C et al. Nasal chondromesenchymal hamartoma in young children: CT and MRI findings and review of the literature. World J Surg Oncol 2014;12:257CrossRefGoogle ScholarPubMed
Uzomefuna, V, Russel, G, McDermott, M. Nasal chondromesenchymal hamartoma with no nasal symptoms. BMJ Case Rep 2012:bcr1120125148Google ScholarPubMed
Kim, JE, Kim, H, Kim, J, Ko, Y, Chung, S. Nasal chondromesenchymal hamartoma: CT and MR imaging findings. Korean J Radiol 2009;10:416–9CrossRefGoogle ScholarPubMed
Sarin, V, Singh, B, Prasher, P. A silent nasal mass with ophthalmic presentation. Orbit 2010;29:367–9CrossRefGoogle ScholarPubMed
El Behery, R, Lazenby, A, Nelson, M, Grove, J, Huang, D, Smith, R, Bridge, JA. Translocation t(12;17)(q24.1;q21) as the sole anomaly in a nasal chondromesenchymal hamartoma arising in a patient with pleuropulmonary blastoma. Pediatric Dev Pathol 2012;15:249–53CrossRefGoogle Scholar
Shet, T, Borges, A, Nair, C, Desai, S. Two unusual lesions in the nasal cavity of infants--a nasal chondromesenchymal hamartoma and an aneurysmal bone cyst like lesion. More closely related than we think? Int J Pediatr Otorhinolaryngol 2004;68:359–64CrossRefGoogle Scholar
Kim, B, Park, S, Min, H, Rhee, J, Wang, KC. Nasal chondromesenchymal hamartoma of infancy clinically mimicking meningoencephalocele. Pediatr Neurosurg 2004;40:136–40CrossRefGoogle ScholarPubMed
Moon, SH, Kim, MM. Nasal chondromesenchymal hamartoma with incomitant esotropia in an infant: a case report. Can J Ophthalmol 2014;49:e30–2CrossRefGoogle Scholar
Nakagawa, T, Sakamoto, T, Ito, J. Nasal chondromesenchymal hamartoma in an adolescent. Int J Pediatr Otorhinolaryngol Extra 2009;4:111–13CrossRefGoogle Scholar
Ünal, A, Kum, RO, Avcı, Y, Ünal, D. Nasal chondromesenchymal hamartoma, a rare pediatric tumor: case report. Turkish J Pediatr 2016;58:208–11CrossRefGoogle ScholarPubMed
Avcı, H, Çomoğlu, Ş, Öztürk, E, Bilgiç, B, Kıyak, ÖE. Nasal chondromesenchymal hamartoma: a rare nasal benign tumor. Kulak Burun Bogaz Ihtisas Dergisi 2016;26:300–3CrossRefGoogle ScholarPubMed
Nakaya, M, Yoshihara, S, Yoshitomi, A, Baba, S. Endoscopic endonasal excision of nasal chondromesenchymal hamartoma with intracranial extension. Eur Ann Otorhinolaryngol Head Neck Dis 2017;134:423–5CrossRefGoogle ScholarPubMed
Golbin, D, Ektova, A, Demin, M, Lasunin, N, Cherekaev, V. Nasal chondromesenchymal hamartoma with skull base and orbital involvement: case presentation Cureus 2018;10:e2892Google ScholarPubMed
Schultz, K, Williams, G, Kamihara, J, Sterwart, D, Harris, A, Bauer, A et al. DICER1 and associated conditions: identification of at-risk individuals and recommended surveillance strategies. Clin Cancer Res 2018;24:2251–61CrossRefGoogle ScholarPubMed
Chae, HJ, Suk, JH, Lee, SK. Nasal chondromesenchymal hamartoma. Korean J Pathol 1999;33:225–7Google Scholar
Itoh, T, Ishikawa, N, Kishimoto, S, Ohio, K, Lida, H. A case of nasal chondromesenchymal hamartoma with severe orbital deviation in infant. J Japan Soc Head Neck Surg 2002;12:45–51CrossRefGoogle Scholar
Alrawi, M, McDermott, M, Russell, J. Nasal chondromesynchymal hamartoma presenting in an adolescent. Int J Pediatr Otorhinolaryngol 2003;67:669–72CrossRefGoogle Scholar
Jeyakumar, A, McEvoy, T, Fettman, N. Neonatal nasal mass: chondromesenchymal hamartoma. Int J Pediatric Otorhinolaryngol Extra 2011;6:223–5CrossRefGoogle Scholar
Cho, YC, Sung, IY, Son, JH, Ord, R. Nasal chondromesenchymal hamartoma: report of a case presenting with intraoral signs. J Oral Maxillofac Surg 2013;71:72–6CrossRefGoogle ScholarPubMed