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Multiple malignancies in a patient with bilateral retinoblastoma

Published online by Cambridge University Press:  29 June 2007

H. M. Eha ,
A. J. M. Balm ,
D. de Jong  and
L. J. Van't Veer
H. M. Eha
Affiliation:
Department of Radiotherapy, The Netherlands Cancer Institute (Antoni van Leeuwenhoek Hospital), Amsterdam, The Netherlands.
A. J. M. Balm*
Affiliation:
Departments of Otolaryngology/Head and Neck SurgeryThe Netherlands Cancer Institute (Antoni van Leeuwenhoek Hospital), Amsterdam, The Netherlands.
D. de Jong
Affiliation:
Department of Pathology, The Netherlands Cancer Institute (Antoni van Leeuwenhoek Hospital), Amsterdam, The Netherlands.
L. J. Van't Veer
Affiliation:
Department of Pathology, The Netherlands Cancer Institute (Antoni van Leeuwenhoek Hospital), Amsterdam, The Netherlands.
*
Address for correspondence: A. J. M. Balm, M.D., Department of Otolaryngology/Head and Neck Surgery, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands. Fax: +31-20-5122554 e-mail: [email protected]
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Abstract

A case is presented of a patient with bilateral retinoblastoma, treated at infancy with surgery, chemotherapy and radiotherapy, who subsequently developed at least four additional histologically distinct malignancies: a Ewing sarcoma of the left fibula, two extraskeletal osteosarcomas of the left lower extremity, a mucoepidermoid carcinoma of the right parotid gland and a squamous cell carcinoma of the left paranasal cavity.

In addition to retinoblastoma, patients with a germline RB-1 mutation are at high risk of second primary malignancies. An additive carcinogenic effect of cytotoxic therapy in these patients has been assumed. Patients with hereditary retinoblastoma should be under life-long follow-up programmes including a regular head and neck examination for detection of new primaries, especially in the radiation field of the presenting retinoblastoma.

Keywords

RetinoblastomaNeoplasms, multiple primary
Type
Clinical Records
Information
The Journal of Laryngology & Otology , Volume 112 , Issue 2 , February 1998 , pp. 189 - 192
Copyright
Copyright © JLO (1984) Limited 1998

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References

Draper, G. J., Sanders, B. M., Kingston, J. E. (1986) Second primary neoplasms in patients with retinoblastoma. British Journal of Cancer 53: 661–671.CrossRefGoogle ScholarPubMed
Eng, C., Li, F. P., Abramson, D. H., Ellsworth, R. M., Wong, F. L., Goldman, M. B., Seddon, J., Tarbell, N., Boice, J. D. (1993) Mortality from second tumours among long-term survivors of retinoblastoma. Journal of the National Cancer Institute 85: 1121–1128.CrossRefGoogle ScholarPubMed
Fontanesi, J., Parham, D. M., Pratt, C., Meyer, D. (1995) Second malignant neoplasms in children with retinoblastoma: the St Jude Children's Research Hospital experience. Ophthalmic Genetics 16: 105–108.CrossRefGoogle ScholarPubMed
Friend, S. H., Bernards, R., Rogelj, S., Weinberg, R. A., Rapaport, J. M., Albert, D. M., Dryja, T. P. (1986) A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma. Nature 323: 643–646.CrossRefGoogle ScholarPubMed
Hawkins, M. M., Kinnier Wilson, L. M., Burton, H. S., Potok, M. H. N., Winter, D. L., Marsden, H. B., Stovall, M. A. (1996) Radiotherapy, alkylating agents, and the risk of bone cancer after childhood cancer. Journal of the National Cancer Institute 88: 270–278.CrossRefGoogle ScholarPubMed
Kay, R. M. M., Eckardt, J. J., Mirra, J. M. (1996) Osteosarcoma and Ewing's sarcoma in a retinoblastoma patient. Clinical Orthopaedics and Related Research 323: 284–287.CrossRefGoogle Scholar
Knudson, A. G. Jr (1971) Mutation and cancer: statistical study of retinoblastoma. Proceedings of the National Academy of Sciences of the United States of America 68: 820–823.CrossRefGoogle ScholarPubMed
Shields, J. A., Augsburger, J. J. (1981) Current approaches to the diagnosis and management of retinoblastoma. Survey of Ophthalmology 25: 347–371.CrossRefGoogle Scholar
Smith, L. M., Donaldson, S. S., Egbert, P. R., Link, M. P., Bagshaw, M. A. (1989) Aggressive management of second primary tumours in survivors of hereditary retinoblastoma. International Journal of Radiation Oncology, Biology, Physics 17: 499–505.CrossRefGoogle ScholarPubMed
Strong, L. C. (1993) Genetic implications for long-term survivors of childhood cancer. Cancer (Suppl) 71: 3435–3440.3.0.CO;2-H>CrossRefGoogle ScholarPubMed
Weinberg, R. A. (1995) The retinoblastoma protein and cell cycle control. Cell 81: 323–330.CrossRefGoogle ScholarPubMed
Winther, J., Olsen, J. H., de Nully Brown, P. (1988) Risk of non-ocular cancer among retinoblastoma patients and their parents. Cancer 62: 1458–1462.3.0.CO;2-2>CrossRefGoogle Scholar