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A morphological and morphometric study of the peripheral process of the human vestibular nerve following posterior cranial fossa neurectomy

Published online by Cambridge University Press:  29 June 2007

Ken Kitamura ,
Katsumasa Takahashi ,
Hiroyuki Kakoi ,
Taro Sugimoto  and
Herbert Silverstein
Ken Kitamura*
Affiliation:
Departments of Otolaryngology, School of Medicine, Tokyo Medical and Dental University, Tokyo.
Katsumasa Takahashi
Affiliation:
Departments of Otolaryngology, School of Medicine, Jichi Medical School, Tochigi-ken, Japan.
Hiroyuki Kakoi
Affiliation:
Departments of Otolaryngology, School of Medicine, Jichi Medical School, Tochigi-ken, Japan.
Taro Sugimoto
Affiliation:
Departments of Otolaryngology, School of Medicine, Tokyo Medical and Dental University, Tokyo.
Herbert Silverstein
Affiliation:
Ear Research Foundation, Sarasota, FL, USA.
*
Address for correspondence: K. Kitamura M.D., Department of Otolaryngology, School of Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan. Fax: +81 3 5803 0146 e-mail: [email protected]
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Abstract

Three vestibular nerve specimens removed at transmeatal neurectomy were studied in order to understand better retrograde degeneration and regeneration after vestibular neurectomy in the posterior cranial fossa. In two cases this procedure followed retrolabyrinthine retrosigmoid posterior fossa vestibular neurectomy. The subjects, three patients with Menière's disease, were compared with one another and two autopsy controls with no known otological problem. The specimens were obtained at the distal end of the internal auditory canal and transversely sectioned. Many collapsed Schwann cell basement membranes were observed. The ratio of small-diameter nerve fibres increased significantly after neurectomy. Onion bulb formation around myelinated nerve fibres with small diameters and Schwann cell proliferation around the soma of vestibular ganglion cells reflected remyelination. We conclude that peripheral processes of vestibular nerve fibres can undergo retrograde degeneration and subsequent regeneration after transection of the central process.

Keywords

Vestibular nerveSurgery, operativeNerve degenerationNerve regeneration
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 113 , Issue 11 , November 1999 , pp. 967 - 972
Copyright
Copyright © JLO (1984) Limited 1999

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