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MicroRNAs in acquired sensorineural hearing loss

Published online by Cambridge University Press:  30 July 2019

H H R Chen ,
P Wijesinghe  and
D A Nunez
H H R Chen
Affiliation:
Division of Otolaryngology, Department of Surgery, University of British Columbia, Vancouver, Canada
P Wijesinghe
Affiliation:
Division of Otolaryngology, Department of Surgery, University of British Columbia, Vancouver, Canada Vancouver Coastal Health Research Institute, Canada
D A Nunez*
Affiliation:
Division of Otolaryngology, Department of Surgery, University of British Columbia, Vancouver, Canada Vancouver Coastal Health Research Institute, Canada
*
Author for correspondence: Prof Desmond A Nunez, Division of Otolaryngology Head and Neck Surgery, Department of Surgery, University of British Columbia, Gordon and Leslie Diamond Health Care Centre, 4th Floor, 2775 Laurel Street, Vancouver, BC, Canada V5Z 1M9 E-mail: [email protected] Fax: +1 604 875 5018
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Abstract

Objective

This review summarises the current literature on the role of microRNAs in presbyacusis (age-related hearing loss) and sudden sensorineural hearing loss.

Methods

Medline, PubMed, Web of Science and Embase databases were searched for primary English-language studies, published between 2000 and 2017, which investigated the role of microRNAs in the pathogenesis of presbyacusis or sudden sensorineural hearing loss. Quality of evidence was assessed using the National Institutes of Health quality assessment tool.

Results

Nine of 207 identified articles, 6 of good quality, satisfied the review's inclusion criteria. In presbyacusis, microRNAs in pro-apoptotic and autophagy pathways are upregulated, while microRNAs in proliferative and differentiation pathways are downregulated. Evidence for microRNAs having an aetiological role in sudden hearing loss is limited.

Conclusion

A shift in microRNA expression, leading to reduced cellular activity and impaired inner-ear homeostasis, may contribute to the pathogenesis of presbyacusis.

Keywords

MicroRNAsMiRNA-MRNA InteractionsPresbycusisSensorineural Hearing Loss
Type
Review Articles
Information
The Journal of Laryngology & Otology , Volume 133 , Issue 8 , August 2019 , pp. 650 - 657
Copyright
Copyright © JLO (1984) Limited, 2019 

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Footnotes

Prof D A Nunez takes responsibility for the integrity of the content of the paper

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