Hostname: page-component-586b7cd67f-l7hp2 Total loading time: 0 Render date: 2024-11-25T21:55:26.185Z Has data issue: false hasContentIssue false
  • English
  • Français

Marijuana smoking as a possible cause of tongue carcinoma in young patients

Published online by Cambridge University Press:  29 June 2007

G. Almadori ,
G. Paludeeri ,
M. Cerullo ,
F. Orraviani  and
L. D'alatri
G. Almadori*
Affiliation:
Rome, Italy
G. Paludeeri
Affiliation:
Rome, Italy
M. Cerullo
Affiliation:
Rome, Italy
F. Orraviani
Affiliation:
Rome, Italy
L. D'alatri
Affiliation:
Rome, Italy
*
Giovanni Almadori, MD, Institute of Otorhinolaryngology of the Catholic University of the Sacred Heart, Largo Agostino Gemelli, 8, 00168 Roma (Italy).
Get access Rights & Permissions [Opens in a new window]

Abstract

A case of T1N0M0 carcinoma of the tongue in a male 23-year-old ‘regular’ marijuana smoker is described. Hemiglossectomy and complete bilateral neck dissection were carried out. No post-operative radiotherapy was given as the resection margins were histologically negative. The tumour recurred one year later in the left cervical region involving the mandible and surgery was again performed, but after three months, neck disease was still evident. The case described case implies the introduction of marijuana as a possible new risk factor in the development of oral cavity tumours. Resection of the primary lesion has to be as wide as possible even in T1 cases, due to the aggressive biological behaviour of such tumours in young subjects.

Type
Clinical Records
Information
The Journal of Laryngology & Otology , Volume 104 , Issue 11 , November 1990 , pp. 896 - 899
Copyright
Copyright © JLO (1984) Limited 1990

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Ackerman, L. V., Del Regato, J. A. (1970) Cancer diagnosis, treatment and prognosis. 4th ed.C. V. Mosby Company, St Louis, p 183–354.Google Scholar
Amsterdam, J. T., Strawitz, J. G. (1982) Squamous cell carcinoma of the oral cavity in young adults. Journal of Surgical Oncology, 19: 65–68.CrossRefGoogle ScholarPubMed
Byres, R. M. (1975) Squamous cell carcinoma of the oral tongue in patients less than 30 years of age. American Journal of Surgery, 130: 475–478.Google Scholar
Byres, R. M., Wolf, P. F., Ballantyne, A. J. (1988) Rationale for elective modified neck dissections. Head and Neck Surgery, 10: 160–167.CrossRefGoogle Scholar
Carniol, P. J., Fried, M. P. (1982) Head and neck carcinoma in patients under 40 years of age. Annals of Otology, Rhinology and Laryngology, 91: 152–155.CrossRefGoogle ScholarPubMed
Chopra, G. S. (1973) Studies on psycho-clinical aspects of long-term marijuana use in 124 cases. International Journal of the Addictions, 8: 1015–1026.CrossRefGoogle Scholar
Clark, R. M., Rosen, I. B., Lapperriere, N. J. (1982) Malignant tumours of the head and neck in a young population. American Journal of Surgery, 144: 459–461.Google Scholar
Cushman, P., Grieco, M., Gupta, S. (1975) Reduction in T-lymphocyte forming active rosettes in chronic marijuana smokers. International Journal of Clinical Pharmacology and Biopharmacology, 12: 217–220.Google ScholarPubMed
Cushman, P., Khurana, R. (1976) Marijuana and T-lymphocyte rosettes. Clinical Pharmacology and Therapeutics, 19: 310–317.CrossRefGoogle ScholarPubMed
Cusumano, R. J., Persky, M. S. (1988) Squamous cell carcinoma of the oral cavity and oropharynx in young adults. Head and Neck Surgery, 10: 229–234.Google Scholar
Depue, R. H. (1986) Rising mortality from cancer of the tongue in young white males. New England Journal of Medicine, 315: 647.Google Scholar
Donald, P. J. (1986) Marijuana smoking–possible cause of head and neck carcinoma in young patients. Otolaryngology-Head and Neck Surgery, 94: 517–521.Google Scholar
Fehr, K. O., Kalant, H. (1972) Analysis of cannabis smoke obtained under different combustion conditions. Canadian Journal of Physiology and Pharmacology, 50: 761–767.CrossRefGoogle ScholarPubMed
Fehr, K. O., Kalant, H. (1983) Cannabis health hazards: proceedings of an ARF/WHL scientific meeting on adverse health and behavioural consequences of cannabis use. Toronto, 1983, Addiction Research Foundation, p 501–563.Google Scholar
Fergusson, R. P., Hasson, J., Walker, S. (1989) Metastatic lung cancer in a young marijuana smoker. Journal of the American Medical Association, 261: 41–42.CrossRefGoogle Scholar
Fleischman, R. W., Baker, J. R., Rosenkrantz, H. (1979) Pulmonary pathologic changes in rats exposed to marijuana smoke for one year. Toxicology and Applied Pharmacology, 47: 557–566.CrossRefGoogle Scholar
Frazell, E. L., Lucas, J. C. (1962) Cancer of the tongue: report on the management of 1.554 patients. Cancer, 15: 1085–1099.Google Scholar
Gong, H., Fligiel, S., Tashkin, D. P., Barbes, R. G. (1987), Tracheobronchial changes in habitual, heavy smokers of marijuana with and without tobacco. American Review of Respiratory Diseases, 136: 142–149.Google Scholar
Goyanes, A. D., Frazell, E. L. (1971) Cancer of the tongue in young persons. Journal of Surgical Oncology, 3: 421–429.Google Scholar
Guarisco, J. L., Cheney, M. L., Lejenue, F. E., Reed, H. T. (1988) Isolated uvulitis secondary to marijuana use. Laryngoscope, 98: 1309–1312.CrossRefGoogle ScholarPubMed
Henderson, R. L., Tennant, F. S., Guerry, R. (1972) Respiratory manifestations of hashish smoking. Archives of Otolaryngology, 95: 248–251.Google Scholar
Hoffman, D., Brunneman, C. K., Gori, B. G., Wynder, E. L. (1975) On the carcinogenicity of marijuana smoke. Recent Advances of Phytochemistry, 9: 63–81.Google Scholar
Huber, G. L., Simmons, G. A., McCarthy, C. R., Cutting, M. B., Laguarda, R., Pereira, W. (1975) Depressant effect of marijuana smoke on anti-bactericidal activity of pulmonary alveolar macrophages. Chest, 68: 769–773.Google Scholar
Kinnebrew, M., Gettleman, L., Carr, R. F., Beadley, R. (1984) Squamous cell carcinoma of the tongue in a young woman. Report of a case with ethiologic considerations. Oral Surgery, Oral Medicine, Oral Pathology, 58: 696–698.Google Scholar
Jenkin, V. K., Ray, P., Ellis, H., Griffiths, C. M., Perry, R. R., Olson, M. H. (1976) Lymphocyte response in patients with head and neck cancer. Archives of Otolargyngology, 102: 596–599.Google Scholar
Jones, J. B., Lampe, M. B., Cheung, H. W. (1989) Carcinoma of the tongue in young patients. Journal of Otolaryngology, 18: 105–108.Google ScholarPubMed
Leipzig, B., Cummings, C. W., Johnson, J. J., Chung, C. T., Sagerman, R. H. (1982) Carcinoma of the anterior tongue. Annals of Otology, Rhinology and Laryngology, 91: 94–97.Google Scholar
Leuchtenberger, C., Leuchtenberger, R. (1971) Morphological and cytochemical effects of marijuana cigarette smoke on epithelioid cells of lung explain from mice. Nature, 234: 227–229.CrossRefGoogle Scholar
Leuchtenberger, C., Leuchtenberger, R., Schneider, A. (1973 a) Effects of marijuana and tobacco smoke on human lung physiology. Nature, 241: 137–139.CrossRefGoogle ScholarPubMed
Leuchtenberger, C., Leuchtenberger, R., Ritter, U. (1973 b) Effects of marijuana and tobacco smoke on DNA and chromosomal complement in human lung explants. Nature, 242: 403–404.Google Scholar
Lipkin, A., Miller, R. H., Woodson, G. E. (1985) Squamous cell carcinoma of the oral cavity, pharynx and larynx in young adults. Laryngoscope, 95: 790–793.CrossRefGoogle ScholarPubMed
Luce, D., Guenel, P., Leclerc, A., Brugere, J., Point, D., Rodriguez, J. (1988) Alcohol and tobacco consumption in cancer of the mouth, pharynx and larynx. A study of 316 female patients. Laryngoscope, 98: 313–316.Google Scholar
Magus, R. D., Harris, L. S. (1971) Carcinogenic potentials of marijuana smoke condensate. Federation Proceedings (Abstract), 30: 179.Google Scholar
McGregor, G. I., Davis, N., Robins, R. E. (1983) Squamous cell carcinoma of the tongue and lower oral cavity in patients under 40 years of age. American Journal of Surgery, 146: 88–92.Google Scholar
Mendez, P., Maves, M. D., Panje, W. R. (1985) Squamous cell carcinoma of the head and neck in patients under 40 years of age. Archives of Otolaryngology, 111: 762–764.Google Scholar
Mitsuyama, S. S., Jarvik, L. F., Fu, T. K., Yen, F. S. (1976) Chromosome studies before and after supervised marijuana smoking. In: Pharmacology of Marijuana (Braude, M.C., Szara, S., eds), vol. 2, New York.Google Scholar
Moore, C., Catlin, D. (1967) Anatomic origins and locations of oral cancer. American Journal of Surgery, 114: 510–513.CrossRefGoogle ScholarPubMed
Morris, R. R. (1985) Human pulmonary histopathological changes from marijuana smoking. Journal of Forensic Sciences, 30: 345–349.CrossRefGoogle ScholarPubMed
Nahas, G. G., Desoize, B., Armand, J. P., Hsu, J., Morishima, A. (1975) Natural cannabinoides: Apparent depression of nuclei acids and protein synthesis and cultures of human lymphocytes. In: Pharmacology of Marijuana (Szara, S., Braude, M., eds), New York, p 177–206.Google Scholar
Newman, A. N., Rice, D. H., Ossof, R. H., Sisson, G. A. (1983) Carcinoma of the tongue in persons younger than 30 years of age. Archives of Orolaryngology, 109: 302–304.Google Scholar
Novotny, M., Lee, M. L., Bartle, K. D. (1976) A possible chemical basis for the higher mutagenicity of marijuana smoke as compared to tobacco smoke. Experentia, 32: 280–282.Google Scholar
Petersen, B. H., Lemberger, L., Graham, J., Dalton, B. (1975) Alterations in the cellular-mediated immune responsiveness of chronic marijuana smokers. Psychopharmacology Communications, 1: 67–74.Google Scholar
Petersen, R. C. (1979) Importance of inhalation patterns in determining effects of marijuana use (letter). Lancet, 1: 727–728.Google Scholar
Randall, C. J., Shaw, H. J. (1986) Malignant tumours of the tongue in young adults. Experience of a secondary referral centre. Journal of Laryngology and Otology, 100: 1295–1298.Google Scholar
Renault, P. F., Schuster, C. R., Freedman, D. X., Sikic, B., Nebel de Mello, D., Halaris, A. (1974) Repeated administration of marijuana smoke to humans. Archives of General Psychiatry, 31: 95–102.Google Scholar
Rosenkrants, H., Fleischman, R. W. (1979) Effects of cannabis on lungs. In: Advances in the Biosciences (Nahas, C. B., Paton, W. D. M., eds), vol. 22–23, Pergamon Press: New York, p 279–299.Google Scholar
Roy, P. F., Magnant-Lapointe, F., Huy, N. D., Boutet, M. (1976) Chronic inhalation of marijuana and tobacco in dogs pulmonary pathology. Research Communications in Chemical Pathology and Pharmacology, 14: 305–317.Google Scholar
Schantz, S. P., Byres, R. M., Goepfert, H. (1988 a) Tobacco and cancer of the tongue in young adults. Journal of the American Medical Association, 259: 1943–1944.Google Scholar
Schantz, S. P., Byres, R. M., Goepfert, H., Shallenberger, R. C., Beddinghield, N. (1988 b) The implication of tobacco use in the young adults with head and neck cancer. Cancer, 62: 1374–1380.Google Scholar
Schmidt, W., Popham, R. E. (1981) The role of drinking and smoking in mortality from cancer and other causes in male alcoholics. Cancer, 47: 1031–1041.Google Scholar
Scully, C., Prime, S. S., Maitland, N. J., Cox, M. F. (1987) Human papillomavirus in biopsies of human oral tissue. Lancet, 1: 336.CrossRefGoogle Scholar
Shemen, L. J., Klotz, J., Schottenfeld, D., Strong, E. W. (1984) Increase of tongue cancer in young men. Journal of the American Medical Association, 252: 1857.Google Scholar
Sloan, M. P. (1985) Uvulitis from smoking marijuana. Pediatric Notes, 9: 56.Google Scholar
Spitz, M. R., Fueger, J. J., Goepfert, H., Hong, W. K., Newell, G. R. (1988) Squamous cell carcinoma of the upper aerodigestive tract. A case comparison analysis. Cancer, 61: 203–208.3.0.CO;2-6>CrossRefGoogle ScholarPubMed
Tashkin, D. P., Coulson, A. H., Clark, V. A., Simmons, M., Bourque, L. B., Duann, S., Spivey, G. H., Gong, H. (1987) Respiratory symptoms and lung function in habitual heavy smokers of marijuana alone, smokers of marijuana and tobacco, smokers of tobacco alone, and non-smokers. American Review of Respiratory Diseases, 135: 209–216.Google Scholar
Taylor, F. M. (1988) Marijuana as a potential respiratory tract carcinogen: a retrospective analysis of a community hospital population. Southern Medical Journal, 81: 1213–1216.Google Scholar
Tennant, F. S., Preble, M., Prendergast, T. J., Ventry, P. (1971) Medical manifestations associated with hashish. Journal of the American Medical Association, 216: 1965–1969.Google Scholar
Vaughan, C. W., Homburger, F., Shapshay, S. M. (1980) Carcinogenesis in the upper aerodigestive tract. Otolaryngologic Clinics of North America, 13: 403–412.Google Scholar
Venables, C. W., Craft, I. L. (1967) Carcinoma of the tongue in early life. British Journal of Cancer, 21: 645–650.Google Scholar
White, S. C., Brin, S. C., Janicki, B. W. (1975) Mitogen-induced blastogenic responses of lymphocytes from marijuana smokers. Science, 188: 71–72.Google Scholar
Wynder, E. L., Mushinski, M. H., Spicak, J. C., Gridley, G., Blot, W. J., Hoover, R. M. (1984) Tobacco and alcohol consumption in relation to the development of multiple primary cancer. Cancer, 40: 1872–1878.3.0.CO;2-#>CrossRefGoogle Scholar