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Malignant odontogenic myxoma of the maxilla: case with cytogenetic confirmation

Published online by Cambridge University Press:  08 March 2006

Stefan Pahl ,
Wolfram Henn ,
Thomas Binger ,
Ute Stein  and
Klaus Remberger
Stefan Pahl
Affiliation:
Department of Pathology, University of Saarland, Homburg, Germany.
Wolfram Henn
Affiliation:
Department of Human Genetics, University of Saarland, Homburg, Germany.
Thomas Binger
Affiliation:
Department of Oral and Maxillofacial Surgery, University of Saarland, Homburg, Germany.
Ute Stein
Affiliation:
Department of Pathology, University of Saarland, Homburg, Germany.
Klaus Remberger
Affiliation:
Department of Pathology, University of Saarland, Homburg, Germany.
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Abstract

An odontogenic myxoma of the maxilla with an aggressive clinical course is presented. The tumour arose in a 53-year-old patient, recurred two times after extended maxillectomy and ultimately caused the patient’s death by uncontrollable local disease with infiltration of the cranial cavity.

Microscopically, the tumour showed histological features of a low grade malignant myxosarcoma with cellular areas, enhanced mitotic activity and nuclear pleomorphism. Cytogenetic analysis revealed an unexpectedly aberrant hypertetraploid chromosome complement, that was considered as incompatible with the usual karyotypic patterns of benign tumours.

Keywords

MaxillarysinusneoplasmsMyxomaOdontogenictumors
Type
Research Article
Information
The Journal of Laryngology & Otology , Volume 114 , Issue 7 , July 2000 , pp. 533 - 535
Copyright
Royal Society of Medicine Press Limited 2000

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