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Long-term survival outcomes in patients with surgically treated oropharyngeal cancer and defined human papilloma virus status

Published online by Cambridge University Press:  08 November 2016

O T Dale ,
S Sood ,
K A Shah ,
C Han ,
D Rapozo ,
H Mehanna  and
S C Winter
O T Dale*
Affiliation:
Head and Neck Department, John Radcliffe and Churchill Hospitals, Oxford, UK
S Sood
Affiliation:
ENT Department, Great Western Hospital, Swindon, UK
K A Shah
Affiliation:
Head and Neck Department, John Radcliffe and Churchill Hospitals, Oxford, UK
C Han
Affiliation:
Department of Oncology, University of Oxford, UK
D Rapozo
Affiliation:
Institute of Head and Neck Studies and Education, University of Birmingham, UK
H Mehanna
Affiliation:
Institute of Head and Neck Studies and Education, University of Birmingham, UK
S C Winter
Affiliation:
Head and Neck Department, John Radcliffe and Churchill Hospitals, Oxford, UK
*
Address for correspondence: Mr Oliver T Dale, ENT Department, St Michael's Hospital Bristol, Southwell St, Bristol BS2 8EG, UK E-mail: [email protected]
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Abstract

Objective:

This study investigated long-term survival outcomes in surgically treated oropharyngeal cancer patients with known human papilloma virus status.

Methods:

A case note review was performed of all patients undergoing primary surgery for oropharyngeal cancer in a single centre over a 10-year period. Human papilloma virus status was determined via dual modality testing. Associations between clinicopathological variables and survival were identified using a log-rank test.

Results:

Of the 107 cases in the study, 40 per cent (n = 41) were human papilloma virus positive. The positive and negative predictive values of p16 immunohistochemistry for human papilloma virus status were 57 per cent and 100 per cent, respectively. At a mean follow up of 59.5 months, 5-year overall and disease-specific survival estimates were 78 per cent and 69 per cent, respectively. Human papilloma virus status (p = 0.014), smoking status (p = 0.021) and tumour stage (p = 0.03) were significant prognostic indicators.

Conclusion:

The long-term survival rates in surgically treated oropharyngeal cancer patients were comparable to other studies. Variables including human papilloma virus status and tumour stage were associated with survival in patients treated with primary surgery; however, nodal stage and presence of extracapsular spread were non-prognostic.

Keywords

Oropharyngeal NeoplasmsSquamous Cell CarcinomaHead And Neck Neoplasms
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 130 , Issue 11 , November 2016 , pp. 1048 - 1053
Copyright
Copyright © JLO (1984) Limited 2016 

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