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Long-term efficacy of standardised specific subcutaneous immunotherapy in children with persistent allergic rhinitis due to multiple allergens including house dust mites

Published online by Cambridge University Press:  28 January 2018

Y Song
Affiliation:
Department of Otolaryngology – Head Neck Surgery, Third Xiangya Hospital of Central South University, Changsha, Hunan, China
J Long
Affiliation:
Department of Otolaryngology – Head Neck Surgery, Third Xiangya Hospital of Central South University, Changsha, Hunan, China
T Wang
Affiliation:
Department of Otolaryngology – Head Neck Surgery, Third Xiangya Hospital of Central South University, Changsha, Hunan, China
J Xie
Affiliation:
Department of Otolaryngology – Head Neck Surgery, Hunan Children's Hospital, Changsha, China
M Wang
Affiliation:
Department of Otolaryngology – Head Neck Surgery, Hunan Children's Hospital, Changsha, China
G Tan*
Affiliation:
Department of Otolaryngology – Head Neck Surgery, Third Xiangya Hospital of Central South University, Changsha, Hunan, China
*
Address for correspondence: Professor Guolin Tan, Department of Otolaryngology – Head Neck Surgery, Third Xiangya Hospital, Central South University, Changsha 410013, Hunan, China Fax: +86 731 886 18536 E-mail: [email protected]

Abstract

Objectives:

To observe the five-year efficacy of standardised specific subcutaneous immunotherapy for house dust mite allergy in monosensitised and polysensitised children with persistent allergic rhinitis.

Methods:

From January 2007 to August 2009, 236 children with persistent allergic rhinitis were divided into 2 groups: 1 group received standardised specific subcutaneous immunotherapy using house dust mite extract; the other received pharmacotherapy with intranasal corticosteroids and oral antihistamines. A total of 193 patients (106 in the immunotherapy group and 87 in the pharmacotherapy group) completed treatment. Scores for symptoms, total medication and quality of life were evaluated.

Results:

The subcutaneous immunotherapy group demonstrated a significant reduction in visual analogue scale scores, Rhinoconjunctivitis Quality of Life Questionnaire scores and total medication scores (p < 0.05) compared with the pharmacotherapy group. No significant differences in the visual analogue scale and Rhinoconjunctivitis Quality of Life Questionnaire scores were found between the polysensitised and monosensitised subgroups (p > 0.05). No serious adverse events occurred.

Conclusion:

Standardised subcutaneous immunotherapy has long-term efficacy for children with persistent allergic rhinitis. Single-allergen subcutaneous immunotherapy was appropriate for allergic rhinitis caused by multiple allergens, including house dust mites, in the paediatric population.

Type
Main Articles
Copyright
Copyright © JLO (1984) Limited 2018 

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