Hostname: page-component-586b7cd67f-l7hp2 Total loading time: 0 Render date: 2024-11-23T04:28:00.587Z Has data issue: false hasContentIssue false
  • English
  • Français

Long-term effects of topical corticosteroids in the nose

Published online by Cambridge University Press:  29 June 2007

M. Bende  and
J. Mark
M. Bende*
Affiliation:
Departments of Otorhinolaryngology, Central Hospital, Skövde, Sweden.
J. Mark
Affiliation:
Departments of Pathology, Central Hospital, Skövde, Sweden.
*
Department of Otorhinolaryngology, Central Hospital, S-541 85 Skövde, Sweden.
Get access Rights & Permissions [Opens in a new window]

Abstract

In a prospective study, biopsies were taken from the septal mucosa in 21 patients of whom 11 had been using topical nasal corticosteroids. In contrast to the effect of long-term treatment with corticosteroids in the skin, but in accordance with previous investigations of the nasal mucosa, no histopathological changes of significance were found, although the biopsies were taken from different sites. These findings do not suggest that topically corticosteroids are harmful to the nasal mucosa.

Keywords

NoseCorticosteroids
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 106 , Issue 9 , September 1992 , pp. 810 - 812
Copyright
Copyright © JLO (1984) Limited 1992

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Åkerlund, A., Bende, M., Intaglietta, M., Arfors, K.-E. (1991) The effect of oxymetazoline on nasal and sinus mucosal blood flow in the rabbit as measured with laser-Doppler flowmeter. Submitted for publication.Google Scholar
Bende, M. (1983) Blood flow with 133Xe in human nasal mucosa in relation to age, sex and body position. Ada Otolaryngologica, 96: 175–179.CrossRefGoogle ScholarPubMed
Bende, M., Flisberg, K. (1985) Blood flow in nasal polpys. Journal of Laryngology and Otology, 99: 167–169.CrossRefGoogle Scholar
Cauna, N. (1982) Blood and nerve supply of the nasal lining. In The Nose. Upper Airway Physiology and the Atmospheric Environment. 1st Edition. [Proctor, D. F., Andersen, I., eds.] Elsevier Biomedical Press, Amsterdam, New York, Oxford, p 45–69.Google Scholar
Holopainen, E., Malmberg, H., Binder, E. (1982) Long-term follow-up of intra-nasal beclomethasone treatment, a clinical and histological study. Ada Otolaryngologica, Supplement 386: 270–273.CrossRefGoogle Scholar
Klemi, P. J., Virolainen, E., Puhakka, H. (1980) The effect of intranasal beclomethasone dipropionate on the nasal mucosa. Rhinology, 8: 19–24.Google Scholar
Lindqvist, N., Balle, V. H., Karma, P., Karja, J., Lindstrom, D., Makinen, J., Pukander, J., Ruoppi, P., Suonpaa, J., Ostlund, W., Pipkorn, U. (1986) Long-term safety and efficacy of budesonide nasal aerosol in perennial rhinitis: a 12-month multicentre study. Allergy, 41: 179–186.CrossRefGoogle ScholarPubMed
Lindqvist, N., Andersson, M., Bende, M., Loth, S., Pipkorn, U. (1989) The clinical efficacy of budesonide in hay fever treatment is dependent on topical nasal application. Clinical Allergy, 19: 71–76.CrossRefGoogle ScholarPubMed
Mygin, N., Sorensen, H., Pedersen, C. B. (1978) The nasal mucosa during long-term treatment with beclomethasone dipropionate aerosol: a light- and scanning electron microscopic study of nasal polyps. Ada Otolaryngologica, 85: 437–443.Google Scholar
Pierard, G. E., Pierard-Franchimont, C.Ben Mosbah, T.Arreste, Estrada J. (1989) Adverse effects of topical corticosteroids. Acta Dermatology and Venereology, 69: 26–30.Google Scholar
Pipkorn, U., Berge, T. (1983) Long-term treatment with budesonide in vasomotor rhinitis. Ada Otolaryngologica, 95: 167–171.CrossRefGoogle ScholarPubMed
Pipkorn, U., Pukander, J., Suonpaa, J., Makinen, J., Lindqvist, N. (1988) Long-term safety of budesonide nasal aerosol: a 5.5-year follow-up study. Clinical Allergy, 18: 253–259.CrossRefGoogle Scholar
Poynter, D. (1977) Beclomethasone dipropionate aerosol and nasal mucosa. British Journal of Pharmacology, 4: 295–301.Google ScholarPubMed
Sahay, J. N., Ibrahim, N. B. N., Chatterjee, S. S., Nassar, W. Y., Lodge, K. V., Jones, C. W. (1980) Long-term study of flunisolide treatment in perennial rhinitis with special reference to nasal mucosal histology and morphology. Clinical Allergy, 10: 451–457.CrossRefGoogle ScholarPubMed
Serup, J., Holm, P. (1985) Domoprednate (Stermonid), a topical D-homocorticosteroid, skin atrophy and telangectasia. Dermatologica, 170: 189–194.CrossRefGoogle Scholar
Somerma, S., Lassus, A., Salde, L. (1984) Assessment of atrophy of human skin caused by corticosteroids using chamber occlusion and suction blister techniques. Acta Dermatology and Venereology, 64: 41–45.CrossRefGoogle ScholarPubMed
Stefanovic, D. S. (1972) Corticosteroid-induced atrophy of the skin with telangiectasia. British Journal of Dermatology, 87: 548–554.CrossRefGoogle Scholar