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Laryngeal biopsies: are we doing more, and why? A decade of results

Published online by Cambridge University Press:  08 December 2015

S Lim ,
P Sau ,
L Cooper ,
A McPhaden  and
K MacKenzie
S Lim*
Affiliation:
Department of Otolaryngology Head and Neck Surgery, University of Glasgow, Scotland, UK
P Sau
Affiliation:
Department of Medical School, University of Glasgow, Scotland, UK
L Cooper
Affiliation:
Department of Pathology, Glasgow Royal Infirmary, University of Glasgow, Scotland, UK
A McPhaden
Affiliation:
Department of Pathology, Glasgow Royal Infirmary, University of Glasgow, Scotland, UK
K MacKenzie
Affiliation:
Department of Otolaryngology Head and Neck Surgery, University of Glasgow, Scotland, UK
*
Address for correspondence: Dr Shueh Lim, Department of Otolaryngology Head and Neck Surgery, Glasgow Royal Infirmary, 84 Castle Street, Glasgow G4 0SF, Scotland, UK Fax: 0141 211 4999 E-mail: [email protected]
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Abstract

Background:

Over the last decade, we have observed an escalating trend in the number of laryngeal biopsies performed, despite the incidence of laryngeal cancer remaining constant. This study aimed to quantify the rate of laryngeal biopsies and record the indications.

Method:

A retrospective analysis of laryngeal biopsies performed in North Glasgow, Scotland, UK, between 2001 and 2010, was conducted.

Results:

From 2001 to 2010, 3902 laryngeal biopsies were carried out in North Glasgow. Histopathological results indicated the following diagnoses: squamous cell carcinoma, in 889 cases (23 per cent); dysplasia, in 986 cases (25 per cent); ‘no tumour’, in 913 cases (23 per cent); and benign pathology, in the remaining 1084 cases (28 per cent). There has been a significant increase in the number of biopsies performed after 2004, with the incidence of squamous cell carcinoma and benign disease remaining relatively static.

Conclusion:

It is hypothesised that organ preservation strategies, endoscopic resection in early stage laryngeal cancer and chemoradiotherapy in advanced head and neck cancer are responsible for the increase in laryngeal biopsies.

Keywords

LarynxHead And Neck NeoplasmsDysplasiaMalignancyBenign
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 130 , Issue 1 , January 2016 , pp. 100 - 103
Copyright
Copyright © JLO (1984) Limited 2015 

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Footnotes

Presented at the American Academy of Otolaryngology – Head and Neck Surgery Annual Meeting, 9–12 September 2012, Washington, DC, USA, the Laryngology and Rhinology Section Meeting, Royal Society of Medicine, 2 March 2012, London, UK, and the ENT Scotland Meeting, 13 May 2011, Dunblane, Scotland, UK.

References

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3Forastiere, A, Goepfert, H, Maor, M, Pajak, TF, Weber, R, Morrison, W et al. Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer. N Engl J Med 2003;349:2091–8CrossRefGoogle ScholarPubMed
4Mehanna, H, Paleri, V, Robson, A, Wight, R, Helliwell, T. Consensus statement by otorhinolaryngologists and pathologists on the diagnosis and management of laryngeal dysplasia. Clin Otolaryngol 2010;35:170–6CrossRefGoogle ScholarPubMed