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Intratympanic injection with dexamethasone for sudden sensorineural hearing loss

Published online by Cambridge University Press:  05 November 2010

Y-J Tsai ,
J-G Liang ,
W-B Wu ,
Y-F Ding ,
R P-Y Chiang  and
S-M Wu
Y-J Tsai
Affiliation:
Department of Otolaryngology, Shin-Kong Wu-Ho-Su Memorial Hospital, Taipei, Taiwan
J-G Liang
Affiliation:
Department of Otolaryngology, Shin-Kong Wu-Ho-Su Memorial Hospital, Taipei, Taiwan Department of Otolaryngology, Puli Christian Hospital, Nantou, Taiwan
W-B Wu
Affiliation:
School of Medicine, Fu-Jen Catholic University, Taipei, Taiwan
Y-F Ding
Affiliation:
Department of Otolaryngology, Shin-Kong Wu-Ho-Su Memorial Hospital, Taipei, Taiwan
R P-Y Chiang*
Affiliation:
Department of Otolaryngology, Shin-Kong Wu-Ho-Su Memorial Hospital, Taipei, Taiwan Department of Otolaryngology Head and Neck Surgery, School of Medicine, Fu-Jen Catholic University, Taipei, Taiwan
S-M Wu
Affiliation:
Department of Otolaryngology, Shin-Kong Wu-Ho-Su Memorial Hospital, Taipei, Taiwan
*
Address for correspondence: Dr Rayleigh Ping-Ying Chiang, Department of Otolaryngology, Shin-Kong Wu-Ho-Su Memorial Hospital, 95 Wen Chang Road, Shih Lin District, Taipei City, Taiwan Fax: +886 2 25463179 E-mail: [email protected]
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Abstract

Objective:

To investigate the efficacy of intratympanic steroid therapy in adults with sudden sensorineural hearing loss, and to analyse the factors associated with treatment outcome.

Design:

Retrospective study of patients undergoing intratympanic steroid injection for sudden sensorineural hearing loss between 1 January 2006 and 30 June 2007 at a teaching hospital in Taipei, Taiwan.

Results:

Patients who received intratympanic steroid therapy within seven days of disease onset achieved a significantly better response rate (76.1 per cent), compared with the delayed treatment group (50 per cent). The total response rate, after four steroid injections, was 68.9 per cent. Patients with low and mid-frequency hearing loss were more responsive to steroid treatment. Vertigo was a negative prognostic factor for recovery. There were no long-term sequelae of intratympanic steroid treatment.

Conclusion:

Intratympanic steroid injection may be a simple and effective treatment for patients with sudden sensorineural hearing loss.

Keywords

Sudden Sensorineural Hearing LossDexamethasoneIntratympanic TherapyMiddle Ear
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 125 , Issue 2 , February 2011 , pp. 133 - 137
Copyright
Copyright © JLO (1984) Limited 2010

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Footnotes

Presented at the 85th Conference of Taiwan Otolaryngology Society, 7–8 November 2008, Taipei, Taiwan

References

1Wilson, W, Byl, F, Laird, N. The efficacy of steroids in the treatment of idiopathic sudden hearing loss: a double blind clinical study. Arch Otolaryngol 1980;106:772–6CrossRefGoogle ScholarPubMed
2Wilson, W, Veltri, RW, Laird, N, Sprinkle, PM. Viral and epidemiologic studies of idiopathic sudden hearing loss. Otolaryngol Head Neck Surg 1983;91:653–8CrossRefGoogle ScholarPubMed
3Cole, RR, Jahrsdoerfer, RA. Sudden hearing loss: an update. Am J Otol 1988;9:211–15Google ScholarPubMed
4Slattery, WH, Fisher, LM, Iqbal, Z, Friedman, RA, Liu, N. Intratympanic steroid injection for treatment of idiopathic sudden hearing loss. Otolaryngol Head Neck Surg 2005;133:251–9CrossRefGoogle ScholarPubMed
5Gianoli, GJ, Li, JC. Transtympanic steroids for treatment of sudden hearing loss. Otolaryngol Head Neck Surg 2001;125:142–6CrossRefGoogle ScholarPubMed
6Banerjee, A, Parnes, LS. Intratympanic corticosteroids for sudden idiopathic sensorineural hearing loss. Otol Neurotol 2005;26:878–81CrossRefGoogle ScholarPubMed
7Choung, Y-H, Park, K, Shin, YR, Cho, MJ. Intratympanic dexamethasone injection for refractory sudden sensorineural hearing loss. Laryngoscope 2006;116:747–52CrossRefGoogle ScholarPubMed
8Parnes, LS, Sun, AH, Freeman, DJ. Corticosteroid pharmacokinetics in the inner ear fluids: an animal study followed-up by clinical application. Laryngoscope 1999;109:1–17CrossRefGoogle Scholar
9Chandrasekhar, SS. Intratympanic dexamethasone for sudden sensorineural hearing loss: clinical and laboratory evaluation. Otol Neurotol 2001;22:18–23CrossRefGoogle ScholarPubMed
10Lefebvre, PP, Staecker, H. Steroid perfusion of the inner ear for sudden sensorineural hearing loss after failure of conventional therapy: a pilot study. Acta Otolaryngol 2002;122:698–702CrossRefGoogle ScholarPubMed
11Kopke, RD, Hoffer, ME, Wester, D, O'Leary, MJ, Jackson, RL. Targeted topical steroid therapy in sudden sensorineural hearing loss. Otol Neurotol 2001;22:475–9CrossRefGoogle ScholarPubMed