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Influence of topical phenypropanolamine on tachyphylaxis and mucociliary clearance in the human nose

Published online by Cambridge University Press:  29 June 2007

K. Holmberg  and
M. Bende
K. Holmberg
Affiliation:
Göteborg and Stövde, Sweden
M. Bende*
Affiliation:
Göteborg and Stövde, Sweden
*
M. Bende, M.D., Phd., Department of Otolaryngology, Central Hospital, S-541 85 Skövde, Sweden.
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Abstract

Topical nasal phenylpropanolamine in a 2.5 per cent solution (PPA) was used in an evaluation of the possible development of tachyphylaxis and of possible effects on the mucociliary system after one week of treatment in healthy humans. The tendency of PPA to produce tachyphylaxis was evaluated by rhi-nomanometrie measurements of nasal airway resistance after repeated dose-response provocations. The mucociliary transport time was tested with the saccharine-dye test. No reduced dose-response effect or change in mucociliary transport time was found with PPA, thus indicating that one week of treatment does not contribute to such adverse effects.

Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 102 , Issue 5 , May 1988 , pp. 408 - 410
Copyright
Copyright © JLO (1984) Limited 1988

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