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Inflammatory myofibroblastic tumours of the respiratory tract: paediatric case series with varying clinical presentations

Published online by Cambridge University Press:  12 April 2011

M Brodlie ,
S C Barwick ,
K M Wood ,
M C McKean  and
A Welch
M Brodlie*
Affiliation:
Department of Respiratory Paediatrics, Newcastle upon Tyne Hospitals NHS Foundation Trust, Freeman Hospital, Newcastle upon Tyne, UK Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
S C Barwick
Affiliation:
Department of Respiratory Paediatrics, Newcastle upon Tyne Hospitals NHS Foundation Trust, Freeman Hospital, Newcastle upon Tyne, UK
K M Wood
Affiliation:
Department of Cellular Pathology, Newcastle upon Tyne Hospitals NHS Foundation Trust, Royal Victoria Infirmary, Newcastle upon Tyne, UK
M C McKean
Affiliation:
Department of Respiratory Paediatrics, Newcastle upon Tyne Hospitals NHS Foundation Trust, Freeman Hospital, Newcastle upon Tyne, UK
A Welch
Affiliation:
Department of Paediatric ENT, Newcastle upon Tyne Hospitals NHS Foundation Trust, Freeman Hospital, Newcastle upon Tyne, UK
*
Address for correspondence: Dr Malcolm Brodlie, SpR in Respiratory Paediatrics, c/o Paediatric Respiratory Secretaries, Old Children's Outpatients, Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne NE7 7DN, UK Fax: +44 191 233 1417 E-mail: [email protected]
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Abstract

Objectives:

To highlight the clinical importance of inflammatory myofibroblastic tumours of the respiratory tract in children, and to present a case series of three children which illustrates this tumour's variable clinical presentation.

Case history:

The series includes: a nine-year-old girl with a diagnosis of juvenile idiopathic arthritis, who presented with finger clubbing and was found to have an inflammatory myofibroblastic tumour in her right upper lobe; a 15-year-old adolescent with a left main stem bronchial inflammatory myofibroblastic tumour, who presented with breathlessness and chest pain; and a 12-year-old girl with a tracheal inflammatory myofibroblastic tumour who presented with stridor. In each case, the tumour was resected surgically.

Conclusion:

Inflammatory myofibroblastic tumour are a rare but clinically important and pathologically distinct lesion of the respiratory tract in children. The cases in this series highlight some of the varied clinical presentations of inflammatory myofibroblastic tumours, and illustrate some of this tumour's different anatomical locations within the paediatric respiratory tract.

Keywords

Tracheal NeoplasmsChildBronchial NeoplasmsBronchoscopy
Type
Clinical Records
Information
The Journal of Laryngology & Otology , Volume 125 , Issue 8 , August 2011 , pp. 865 - 868
Copyright
Copyright © JLO (1984) Limited 2011

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