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Impaired specific cellular immunity to the varicella-zoster virus in patients with herpes zoster oticus

Published online by Cambridge University Press:  29 June 2007

Minoru Ikeda ,
Kouichi Hiroshige ,
Yuzuru Abiko  and
Keiko Onoda
Minoru Ikeda*
Affiliation:
Department of Otolaryngology, Nihon University School of Medicine, Tokyo, Japan
Kouichi Hiroshige
Affiliation:
Department of Otolaryngology, Nihon University School of Medicine, Tokyo, Japan
Yuzuru Abiko
Affiliation:
Department of Otolaryngology, Nihon University School of Medicine, Tokyo, Japan
Keiko Onoda
Affiliation:
Department of Otolaryngology, Nihon University School of Medicine, Tokyo, Japan
*
Address for correspondence: Minoru Ikeda, M.D., Department of Otolaryngology, Nihon University School of Medicine, 30–1 Oyaguchi, Itabashi-ku, Tokyo 173, Japan. Fax: 03-3972-1321
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Abstract

The possible involvement of depression on cellular immunity in reactivation of varicella-zoster virus (VZV) in herpes zoster oticus was investigated. The subjects comprised 59 cases of herpes zoster oticus, 33 cases of herpes zoster sine herpete (ZSH) with facial paralysis, and 205 cases of Bell's palsy. The transformation rate of lymphocytes to phytohaemagglutinin in herpes zoster oticus tended to be lower than that in Bell's palsy. In skin tests with purified protein derivatives of tuberculin, the positivity rate in herpes zoster oticus was significantly lower than that in Bell's palsy (p<0.015). In skin tests using VZV antigen, the positivity rate in herpes zoster oticus and ZSH were significantly lower than that of Bell's palsy (p<0.001 and p<0.015, respectively). Thus, it was noted that cellular immunity, especially specific cellular immunity against VZV, was significantly depressed in herpes zoster oticus and ZSH. We consider that depression of specific cellular immunity plays an important role in triggering reactivation of VZV and onset of these diseases.

Keywords

Facial paralysisHerpes zoster oticusVaricella-zoster virus antigen
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 110 , Issue 10 , October 1996 , pp. 918 - 921
Copyright
Copyright © JLO (1984) Limited 1996

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References

Asano, Y., Shiraki, K., Takahashi, M., Nagai, H., Ozaki, T., Yazaki, T. (1981) Soluble skin test antigen of varicellazoster virus prepared from the fluid of infected cultures. Journal of Infectious Diseases 143: 684–692.CrossRefGoogle ScholarPubMed
Baba, K., Shiraki, K., Kanasaki, T., Yamanishi, K., Ogura, P. L., Yabuuchi, H., Takahashi, M. (1987) Specificity of skin test with varicella-zoster virus antigen in varicella-zoster and herpes simplex virus infection. Journal of Clinical Microbiology 25: 2193–2196.CrossRefGoogle Scholar
Bartrop, R. W., Luckhurst, E., Lazarus, L., Kiloh, L. G., Penny, R. (1977) Depressed lymphocyte function after bereavement. Lancet 1: 834–836.CrossRefGoogle ScholarPubMed
Burke, B. L., Steele, R. W., Beard, O. W., Wood, J. S., Cain, T. D., Mermer, D. J. (1982) Immune responses to varicellazoster in the aged. Archives of Internal Medicine 142: 291–293.CrossRefGoogle ScholarPubMed
Djupesland, G., Berdal, P., Johannessen, T. A. (1976) Viral infection as a cause of acute peripheral facial palsy. Archives of Otolaryngology 102: 403–406.Google Scholar
Florman, A. F., Umland, E. T., Ballou, D., Cushing, A. G., McLaren, L. G., Gribble, T. J., Duncan, M. H. (1985) Evaluation of a skin test for chicken pox. Infection Control 6: 314–316.Google Scholar
Furuta, Y., Takasu, T., Fukuda, S., Saito-Matsumura, K. C., Inuyama, Y., Hondo, R., Nagashima, K. (1992) Detection of varicella-zoster virus DNA in human geniculate ganglia by polymerase chain reaction. Journal of Infectious Diseases 166:1157–1159.Google Scholar
Gilden, D. H., Vafai, A., Shtram, Y., Becker, Y., Davlin, M., Wellish, M. (1983) Varicella-zoster virus DNA in human sensory ganglia. Nature 306: 478–480.CrossRefGoogle ScholarPubMed
Hunt, J. R. (1907) On herpetic inflammation of the geniculate ganglion: A new syndrome and its complications. Journal of Nervous and Mental Disease 34: 73–96.Google Scholar
Kamiya, H., Ihara, T., Hattori, A., Iwasa, T., Sakurai, M., Izawa, T., Yamada, A., Takahashi, M. (1977) Diagnostic skin test reactions with varicella virus antigen and clinical application of the test. Journal of Infectious Diseases 136: 784–788.CrossRefGoogle ScholarPubMed
Koike, Y. (1988) An epidemiological and clinical study on idiopathic facial palsy in Japan. Acta Otolaryngologica (Stockholm) (Suppl 446): 7–9.Google ScholarPubMed
Kukimoto, N., Ikeda, M., Yamada, K., Tanaka, M., Tsurumachi, M., Tomita, H. (1988) Viral infections in acute peripheral facial paralysis: Nationwide analysis centering on CF. Acta Otolaryngologica (Stockholm) 446: 17–22.Google ScholarPubMed
La Russa, P., Steinberg, S. P., Seeman, M. D., Gershon, A. A. (1985) Determination of immunity to varicella-zoster virus by means of an intradermal skin test. Journal of Infectious Diseases 152: 869–875.Google Scholar
Miller, A. E. (1980) Selective decline in cellular immune response to varicella-zoster in the elderly. Neurology 30: 582–587.Google Scholar
Ruckdeschel, J. C., Schimpff, S. C., Smyth, A. C., Mardiney, M. R. Jr. (1977) Herpes zoster and impaired cell-associated immunity to the varicella-zoster virus in patients with Hodgkin's disease. American Journal of Medicine 62: 77–85.CrossRefGoogle Scholar
Russel, A. S., Maini, R. A., Bailey, M., Dumonde, D. C. (1972) Cell-mediated immunity to varicella-zoster antigen in acute herpes zoster (shingles). Clinical and Experimental Immunology 14: 181–185.Google Scholar
Scheinberg, M. A., Blacklow, N. R., Goldstein, A. L., Parrino, T. A., Rose, F. B., Cathcart, E. S. (1976) Influenza: response of T-cell lymphopenia to thymosin. New England Journal of Medicine 294: 1208–1211.Google Scholar
Schleifer, S. J., Keller, S. E., Camerino, M., Thornton, J. C., Stein, M. (1983) Suppression of lymphocyte stimulation following bereavement. Journal of the American Medical Association 250: 374–377.CrossRefGoogle ScholarPubMed
Tomita, H., Hayakawa, W., Hondo, R. (1972) Varicella-zoster virus in idiopathic facial palsy. Archives of Otolaryngology 95: 364–368.CrossRefGoogle ScholarPubMed
Tomita, H. (1977) Viral etiology of Bell's palsy. In: Facial Nerve Surgery (Fisch, U., ed.). Kugler Medical Publications, Amsterdeen, pp 356–363.Google Scholar
Watanabe, Y., Ikeda, M., Kukimoto, N., Kuga, M., Tomita, H. (1994) A case report of facial nerve palsy associated with chichenpox. Journal of Larngology and Otology 108: 676–678.CrossRefGoogle Scholar