Hostname: page-component-78c5997874-lj6df Total loading time: 0 Render date: 2024-11-05T05:41:35.612Z Has data issue: false hasContentIssue false
  • English
  • Français

Impact of mean platelet volume on the occurrence and severity of sudden sensorineural hearing loss

Published online by Cambridge University Press:  16 September 2013

M Sagit ,
M Kavugudurmaz ,
S Guler  and
M A Somdas
M Sagit*
Affiliation:
Department of ENT, Kayseri Training and Research Hospital, Turkey
M Kavugudurmaz
Affiliation:
Department of ENT, Kayseri Training and Research Hospital, Turkey
S Guler
Affiliation:
Department of ENT, Kayseri Training and Research Hospital, Turkey
M A Somdas
Affiliation:
Department of ENT, Kayseri Training and Research Hospital, Turkey
*
Address for correspondence: Dr Mustafa Sagit, Kayseri Eğitim ve Araştırma Hastanesi KBB Kliniği, Sanayi Mah Atatürk Bulvarı Hastane Cad 78, 38010, Kayseri, Turkey Fax: +90 352 320 73 13 E-mail: [email protected]
Get access Rights & Permissions [Opens in a new window]

Abstract

Objective:

We aimed to determine: (1) whether mean platelet volume was elevated in patients with sudden sensorineural hearing loss, compared with healthy controls; and (2) whether mean platelet volume level was related to hearing loss severity.

Materials and methods:

The study included 31 patients with sudden sensorineural hearing loss and 31 age- and sex-matched, healthy controls. Peripheral venous blood samples were taken from subjects and mean platelet volume and levels of glucose, total cholesterol, high-density lipoprotein, low-density lipoprotein and triglyceride were measured.

Results:

Mean platelet volume was significantly greater in the sudden sensorineural hearing loss group compared with the control group. However, there was no significant correlation between mean platelet volume level and hearing loss severity.

Conclusion:

Mean platelet volume, a determinant of platelet activation, is elevated in patients with sudden sensorineural hearing loss. To our knowledge, this is the first report investigating mean platelet volume levels in such patients. Our findings indirectly support the hypothesis of vascular impairment as a pathogenetic factor in sudden sensorineural hearing loss.

Keywords

Sensorineural Hearing LossPathogenesisPlateletsMorphologyPlatelet Activation
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 127 , Issue 10 , October 2013 , pp. 972 - 976
Copyright
Copyright © JLO (1984) Limited 2013 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1Ballesteros, F, Alobid, I, Tassies, D, Reverter, JC, Scharf, RE, Guilemany, JM et al. Is there an overlap between sudden neurosensorial hearing loss and cardiovascular risk factors? Audiol Neurootol 2009;14:139–45CrossRefGoogle ScholarPubMed
2Tran, BH. Endolymphatic deafness: a particular variety of cochlear disorder. ORL J Otorhinolaryngol Relat Spec 2002;64:120–4CrossRefGoogle ScholarPubMed
3Um, JY, Jang, CH, Kim, K, Kim, SJ, Kim, NH, Moon, PD et al. Candidate genes of cerebrovascular disease and sudden sensorineural hearing loss. Clin Appl Thromb Hemost 2010;16:559–62CrossRefGoogle ScholarPubMed
4Cadoni, G, Scipione, S, Rocca, B, Agostino, S, La Greca, C, Bonvissuto, D et al. Lack of association between inherited thrombophilic risk factors and idiopathic sudden sensorineural hearing loss in Italian patients. Ann Otol Rhinol Laryngol 2006;115:195–200CrossRefGoogle ScholarPubMed
5Yildiz, Z, Ulu, A, Incesulu, A, Ozkaptan, Y, Akar, N. The importance of thrombotic risk factors in the development of idiopathic sudden hearing loss. Clin Appl Thromb Hemost 2008;14:356–9CrossRefGoogle ScholarPubMed
6Capaccio, P, Ottaviani, F, Cuccarini, V, Bottero, A, Schindler, A, Cesana, BM et al. Genetic and acquired prothrombotic risk factors and sudden hearing loss. Laryngoscope 2007;117:547–51CrossRefGoogle ScholarPubMed
7Ciuffetti, G, Scardazza, A, Serafini, G, Lombardini, R, Mannarino, E, Simoncelli, C. Whole-blood filterability in sudden deafness. Laryngoscope 1991;101:65–7CrossRefGoogle ScholarPubMed
8Suckfull, M, Wimmer, C, Reichel, O, Mees, K, Schorn, K. Hyperfibrinogenemia as a risk factor for sudden hearing loss. Otol Neurotol 2002;23:309–11CrossRefGoogle ScholarPubMed
9Park, Y, Schoene, N, Harris, W. Mean platelet volume as an indicator of platelet activation: methodological issues. Platelets 2002;13:301–6CrossRefGoogle ScholarPubMed
10Kamath, S, Blann, AD, Lip, GY. Platelet activation: assessment and quantification. Eur Heart J 2001;22:1561–71CrossRefGoogle ScholarPubMed
11Pizzulli, L, Yang, A, Martin, JF, Lüderitz, B. Changes in platelet size and count in unstable angina pectoris compared to stable or non-cardiac chest pain. Eur Heart J 1998;19:80–4CrossRefGoogle ScholarPubMed
12Kaya, MG, Yarlioglues, M, Gunebakmaz, O, Gunturk, E, Inanc, T, Dogan, A et al. Platelet activation and inflammatory response in patients with non-dipper hypertension. Atherosclerosis 2010;209:278–82CrossRefGoogle ScholarPubMed
13Endler, G, Klimesch, A, Sunder-Plassmann, H, Schillinger, M, Exner, M, Mannhalter, C et al. Mean platelet volume is an independent risk factor for myocardial infarction but not for coronary artery disease. Br J Haematol 2002;117:399–404CrossRefGoogle Scholar
14Bath, P, Algert, C, Chapman, N, Neal, B, PROGRESS Collaborative Group. Association of mean platelet volume with risk of stroke among 3134 individuals with history of CVD. Stroke 2004;35:622–6CrossRefGoogle Scholar
15Mosnier, I, Stepanian, A, Baron, G. Cardiovascular and thromboembolic risk factors in idiopathic sudden sensorineural hearing loss: a case-control study. Audiol Neurootol 2011;16:55–66CrossRefGoogle ScholarPubMed
16Gensini, GF, Comeglio, M, Colella, A. Classical risk factors and emerging elements in the risk profile for coronary artery disease. Eur Heart J 1998;19:53–61Google ScholarPubMed
17Leys, D, Deplanque, D, Mounier-Vehier, C, Mackowiak-Cordoliani, MA, Lucas, C, Bordet, R. Stroke prevention: management of modifiable vascular risk factors. J Neurol 2002; 249:507–17CrossRefGoogle ScholarPubMed
18Kim, CK, Schmalfuss, CM, Schofield, RS, Sheps, DS. Pharmacological treatment of patients with peripheral arterial disease. Drugs 2003;63:637–47CrossRefGoogle ScholarPubMed
19Marcucci, R, Alessandrello Liotta, A, Cellai, AP, Rogolino, A, Berloco, P, Leprini, E et al. Cardiovascular and thrombophilic risk factors for idiopathic sudden sensorineural hearing loss. J Thromb Haemost 2005;3:929–34CrossRefGoogle ScholarPubMed
20Lu, YY, Jin, Z, Tong, BS, Yang, JM, Liu, YH, Duan, M. A clinical study of microcirculatory disturbance in Chinese patients with sudden deafness. Acta Otolaryngol 2008;128:1168–72CrossRefGoogle ScholarPubMed
21Lin, HC, Chao, PZ, Lee, HC. Sudden sensorineural hearing loss increases the risk of stroke. A 5-year follow-up study. Stroke 2008;39:2744–8CrossRefGoogle ScholarPubMed
22Aimoni, C, Bianchini, C, Borin, M, Ciorba, A, Fellin, R, Martini, A et al. Diabetes, cardiovascular risk factors and idiopathic sudden sensorineural hearing loss: a case-control study. Audiol Neurootol 2010;15:111–15CrossRefGoogle ScholarPubMed
23Nakashima, T, Tanabe, T, Yanagita, N, Wakai, K, Ohno, Y. Risk factors for sudden deafness: a case-control study. Auris Nasus Larynx 1997;24:265–70CrossRefGoogle ScholarPubMed
24Rudack, C, Langer, C, Junker, R. Platelet GPIaC807T polymorphism is associated with negative outcome of sudden hearing loss. Hear Res 2004;191:41–8CrossRefGoogle ScholarPubMed
25Dungan, KM, Braithwaite, SS, Preiser, JC. Stress hyperglycaemia. Lancet 2009;373:1798–807CrossRefGoogle ScholarPubMed
26Abramson, N, Melton, B. Leukocytosis: basics of clinical assessment. Am Fam Physician 2000;62:2053–60Google ScholarPubMed
27Mercier, E, Quere, I, Chabert, R, Lallemant, JG, Daures, JP, Berlan, J et al. The 20210A allele of the prothrombin gene is an independent risk factor for perception deafness in patients with venous thromboembolic antecedents. Blood 1999;93:3150–2CrossRefGoogle ScholarPubMed
28Patscheke, JH, Arndt, J, Dietz, K, Zenner, HP, Reuner, KH. The prothrombin G20210A mutation is a risk factor for sudden hearing loss in young patients. Thromb Haemost 2001;86:1118–19CrossRefGoogle ScholarPubMed
29Inanc, T, Kaya, MG, Yarlioglues, M, Ardic, I, Ozdogru, I, Dogan, A et al. The mean platelet volume in patients with non-dipper hypertension compared to dippers and normotensives. Blood Press 2010;19:81–5CrossRefGoogle ScholarPubMed
30Nadar, SK, Blann, AD, Kamath, S, Beevers, DG, Lip, GY. Platelet indexes in relation to target organ damage in high-risk hypertensive patients: a substudy of the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT). J Am Coll Cardiol 2004;44:415–22CrossRefGoogle ScholarPubMed
31McBane, RD, Elliott, MA, White, JG, Charlesworth, JE, Costopoulos, MG, Owen, WG et al. Fechtner syndrome: physiologic analysis of macrothrombocytopenia. Blood Coagul Fibrinolysis 2000;11:243–7Google ScholarPubMed