Hostname: page-component-cd9895bd7-jn8rn Total loading time: 0 Render date: 2024-12-23T08:41:42.942Z Has data issue: false hasContentIssue false
  • English
  • Français

Immunoglobulin G4 related disease isolated to the nasal cavity: a rare cause of nasal obstruction

Published online by Cambridge University Press:  27 August 2014

C Morris ,
T Ng ,
P Kevin  and
N Singh
C Morris
Affiliation:
Department of Otolaryngology, Head and Neck Surgery, Westmead Hospital, University of Sydney, NSW, Australia
T Ng
Affiliation:
Department of Tissue Pathology, ICPMR, Westmead Hospital, Westmead, NSW, Australia
P Kevin
Affiliation:
Department of Otolaryngology, Head and Neck Surgery, Westmead Hospital, University of Sydney, NSW, Australia
N Singh*
Affiliation:
Department of Otolaryngology, Head and Neck Surgery, Westmead Hospital, University of Sydney, NSW, Australia
*
Address for correspondence: Dr Narinder Singh, Department of Otolaryngology, Head and Neck Surgery, Westmead Hospital/University of Sydney, Sydney, NSW 2145, Australia Fax: +612 9893 7440 E-mail: [email protected]
Get access Rights & Permissions [Opens in a new window]

Abstract

Background:

Immunoglobulin G4 related disease is a rare condition. Cases involving the sinonasal region are exceptionally uncommon. This paper describes a case of immunoglobulin G4 related disease isolated solely to the nasal cavity.

Methods:

Case report and literature review.

Results:

A 34-year-old man presented with painless, progressive bilateral nasal obstruction. Clinical examination and imaging findings demonstrated bilateral submucosal swelling of the anterior septum and right external nasal wall. Biopsy revealed immunoglobulin G4 related disease. The patient responded to oral corticosteroids initially, followed by long-term methotrexate.

Conclusion:

To the best of our knowledge, this case represents the first report in the literature of immunoglobulin G4 related disease isolated solely to the nasal cavity.

Keywords

IgG4IgG4-Related Sclerosing DiseaseIgG4-Related DiseaseNasal CavityNasal ObstructionImmunoglobulin GMethotrexateAutoimmune DiseaseEosinophils
Type
Clinical Records
Information
The Journal of Laryngology & Otology , Volume 129 , Issue S1 , January 2015 , pp. S57 - S59
Copyright
Copyright © JLO (1984) Limited 2014 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Footnotes

Presented as a poster at the Australian Society of Otolaryngology Head and Neck Surgery annual scientific meeting, 3–7 April 2011, Melbourne, Australia.

References

1Kamisawa, T, Okamoto, A. IgG4-related sclerosing disease. World J Gastroenterol 2008;14:3948–55CrossRefGoogle ScholarPubMed
2Cheuk, W, Chan, JK. IgG 4-related sclerosing disease: a critical appraisal of an evolving clinicopathologic entity. Adv Anat Pathol 2010;17:303–32Google Scholar
3Deshpande, V, Zen, Y, Chan, JK, Yi, EE, Sato, Y, Yoshino, T et al. Consensus statement on the pathology of IgG4-related disease. Mod Pathol 2012;25:1181–92Google Scholar
4Hamano, H, Kawa, S, Horiuchi, A, Unno, H, Furuya, N, Akamastsu, T et al. High serum IgG4 concentrations in patients with sclerosing pancreatitis. N Engl J Med 2001;344:731–8CrossRefGoogle ScholarPubMed
5Moteki, H, Yasuo, M, Hamano, H, Uehara, T, Usami, S. IgG 4-related chronic rhinosinusitis: a new clinical entity of nasal disease. Acta Otolaryngol 2011;131:518–26CrossRefGoogle Scholar
6Ikeda, R, Awataguchi, T, Shoji, F, Oshima, T. A case report of sinus lesions in IgG4-related sclerosing disease. Otolaryngol Head Neck Surg 2010;142:458–9Google Scholar