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Immediate effects of intravenous tobramycin and gentamicin on human cochlear function

Published online by Cambridge University Press:  29 June 2007

Richard T. Ramsden ,
Peter Wilson  and
William P. R. Gibson
Richard T. Ramsden
Affiliation:
London
Peter Wilson
Affiliation:
London Adderss for reprints: Peter Wilson, Department of Clinical Microbiplogy, The London Hospital, London E.I.
William P. R. Gibson
Affiliation:
London
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Summary

Immediate electrocochleographic changes have been studied in a series of patients following intravenous infusion of either tobramycin or gentamicin. In patients receiving tobramycin, as soon as peak serum levels of antibiotic were reached, a dramatic decrease occurred in the magnitude of the compound VIII nerve action potential (AP), and of the cochlear microphonic (CM). The shape of the AP also changed. The N1 component of the waveform became very small, and N2 increased in size; this is the dissociated pattern of basal coil cochlear damage. The speed of onset of these electrical changes and their apparent reversibility suggests a temporary metabolic block caused by tobramycin. No such changes were observed following infusion of gentamicin.

Type
Clinical records
Information
The Journal of Laryngology & Otology , Volume 94 , Issue 5 , May 1980 , pp. 521 - 531
Copyright
Copyright © JLO (1984) Limited 1980

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