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Human papillomavirus and p53 oncoprotein in verrucous carcinoma of the larynx

Published online by Cambridge University Press:  29 June 2007

Manuel López-Amado ,
Tomás García-Caballero ,
Ascensión Lozano-Ramírez  and
Torcuato Labella-Caballero
Manuel López-Amado*
Affiliation:
Department of Otolaryngology, Catedra of Otolaryngology, School of Medicine, University of Santiago Compostela, La Coruña, Spain
Tomás García-Caballero
Affiliation:
Department of Pathologyt, Catedra of Otolaryngology, School of Medicine, University of Santiago Compostela, La Coruña, Spain
Ascensión Lozano-Ramírez
Affiliation:
Department of Pathologyt, Catedra of Otolaryngology, School of Medicine, University of Santiago Compostela, La Coruña, Spain
Torcuato Labella-Caballero
Affiliation:
Department of Otolaryngology, Catedra of Otolaryngology, School of Medicine, University of Santiago Compostela, La Coruña, Spain
*
Address for correspondence: Manuel López Amado (Servicio ORL), Avda, Carrero Blanco 16-2°D, 27002 Lugo, Spain. Fax: 07-34-81-178052
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Abstract

The incidence of p53 antigen and human papillomavirus (HPV) expression in archival formalin-fixed, paraffin-embedded tissue sections from verrucous carcinoma of the larynx was determined using immunohistochemistry.

The p53 oncoprotein was detected in four of 10 tissue samples (40 per cent). The same number of tumours had HPV antigen, and three cases had both p53 oncoprotein and HPV antigen. All positive cases were from heavy smokers and drinkers.

After surgical treatment, no tumour recurrence was present in our series. Four patients developed a second head and neck neoplasm and death occurred in three. Three of the patients with second tumour had p53 positive immunoreactivity and two had p13 and HPV expression.

Verrucous carcinoma of the larynx presented with overexpression of p53 antigen in a similar percentage to other head and neck cancers. The p53 immunohistochemical determination is well correlated with HPV detection and could have prognostic value in these tumours, but no statistical evidence was present.

Keywords

Laryngeal neoplasmshnmunohistochemistryPapillomavirusesDNA probes, HPV
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 110 , Issue 8 , August 1996 , pp. 742 - 747
Copyright
Copyright © JLO (1984) Limited 1996

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