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Human papilloma virus and carcinoma of the laryngopharynx

Published online by Cambridge University Press:  29 June 2007

D. W. Morgan ,
V. Abdullah ,
R. Quiney  and
S. Myint
D. W. Morgan*
Affiliation:
The Royal National Throat, Nose and Ear Hospital, Gray's Inn Road, London WC1X 8DA.
V. Abdullah
Affiliation:
The Royal National Throat, Nose and Ear Hospital, Gray's Inn Road, London WC1X 8DA.
R. Quiney
Affiliation:
London
S. Myint
Affiliation:
Department of Medical Microbiology. UCMSM, London Current address: Department of Microbiology, University of Leicester, UK.
*
D. W. Morgan, F.R.C.S., Royal Berkshire Hospital, London Road, Reading, Berkshire RG1 5AN.
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Abstract

The presence of human papillomavirus (HPV) genomes 6, 11, 16 and 33 in 16 patients with laryngopharyngeal carcinomas was examined by means of a polymerase chain reaction. HPV genomes were detected in 75 per cent of cases. In hypopharyngeal carcinoma, HPV 6 and 11 were present in adjacent tissue but absent from the tumour. HPV 16 and 33 were present in 40 per cent of laryngeal tumours and adjacent tissue. These results suggest that HPV 16 and 33 may be closely associated with the development of some laryngopharyngeal carcinomas.

Keywords

Papillomavirus (human)Laryngeal neoplasms
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 105 , Issue 4 , April 1991 , pp. 288 - 290
Copyright
Copyright © JLO (1984) Limited 1991

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References

Abramson, A. L., Brandsma, J., Steinberg, B., Winkler, B. (1985) Verrucous carcinoma of the larynx. Archives of Otolaryngology, 111: 709–715.CrossRefGoogle ScholarPubMed
Bryan, R. C., Bevan, I. S., Crocker, J., Young, L. S. (1990) Detection of HPV 6 and 11 in humans of the upper respiratory tract using the polymerase chain reaction. Clinical Otolaryngology, 15: 177–180.CrossRefGoogle ScholarPubMed
Coleman, D. V., Richman, P. I. (1985) Human papillomavirus infection and cancer of the uterine cervix. Journal of Pathology, 145: 207–212.CrossRefGoogle ScholarPubMed
Dallas, J. B., Flanagan, J. L., Nightingale, B. N., Morris, B. J. (1989) Polymerase chain reaction for fast, non-radioactive detection of high and low risk papillomavirus types in routine cervical specimens and in biopsies. Journal of Medical Virology, 27: 105–111.CrossRefGoogle Scholar
De Villiers, E. M., Schneider, A., Gross, G., Zur Hausen, H. (1986) Analysis of benign and malignant urogenital tumours for human papillovirus infection by labelling cellular DNA. Medical Microbiology and Immunology (Berlin), 174: 281–286.CrossRefGoogle Scholar
Hoshikawa, T., Nakajima, T., Uhara, H., Gotoh, M., Shimosato, Y., Tsutsumi, K., Ono, I., Ebihara, S. (1990) Detection of human papillomavirus DNA in laryngeal squamous cell carcinomas by polymerase chain reaction. Laryngoscope, 100: 647–650.CrossRefGoogle ScholarPubMed
Kahn, T., Schwarz, E., Zur Hansen, H. (1986) Molecular cloning and characterization of the DNA of a new human papilloma virus (HPV 30) from a laryngeal carcinoma. International Journal of Cancer, 37: 61–65.Google Scholar
Kashima, H., Mounts, P., Kuhajda, F., Loury, M. (1986) Demonstration of human papilloma virus capsid antigen in carcinoma in situ of the larynx. Annals of Otology, Rhinology and Laryngology, 95: 603–607.Google Scholar
Kashima, H., Kutcher, M., Kessis, T., Levin, L., De-Villiers, E., Shah, K. (1990) Human papilloma virus in squamous cell carcinoma, leukoplakia, lichen planus and clinically normal epithelium of the oral cavity. Annals of Otology, Rhinology and Laryngology, 99: 55–61.CrossRefGoogle Scholar
Kiyabu, M., Shibata, D., Arnheim, N., Martin, W. J., Fitzgibbon, P. L. (1989) Detection of human papillomavirus in formalin fixed invasive squamous carcinomas using the polymerase chain reaction. American Journal of Surgical Pathology, 13: 221–224.Google Scholar
Lancaster, W. D., Norrild, B. (1989) Diagnosis of HPV by DNA hybridization techniques. In: Human Papilloma Virus and Cervical Cancer. (Munoz, N., Bosch, F. X., Jenson, O. M. eds.) Oxford University Press: New York, p 87–103.Google Scholar
Lowell, D. M., Livolsi, V. A., Ludwig, M. E. (1983) Genital condyloma virus infection following pelvic radiation therapy. Report of seven cases. International Journal of Gynaecological Pathology, 2: 294–302.CrossRefGoogle ScholarPubMed
Orth, G. (1986) Epidermodysplasia verruciformis: a model for understanding the oncogenicity of human papilloma virus. In: Papilloma viruses. Ciba Foundation Symposium 120 (Evered, D., Clark, S. eds.) John Wiley: Chichester. p 157–174.Google Scholar
Ostrow, R. S., Manias, D. A., Fong, W. J., Zachow, K. R., Faras, A. J. (1987) Survey of human papilloma virus DNA by filter hybridization Cancer, 59: 429–434.3.0.CO;2-1>CrossRefGoogle Scholar
Scheurlen, W., Stremlau, A., Gissman, L., Hohn, D., Zenner, H., Zur Hausen, H. (1986) Rearranged HPV 16 molecules in an anal and in a laryngeal carcinoma. International Journal of Cancer, 38: 671–676.CrossRefGoogle Scholar
Stoler, M. H., Broker, T. R. (1986) In situ hybridization detection of human papilloma virus DN As and messenger RN As in genital condylomas and a cervical carcinoma. Human Pathology, 17: 1250–1258.Google Scholar
Syrjanen, K., Syrjanen, S., Phyrhonen, S. (1982) Human papillomavirus antigens in lesions of laryngeal squamous cell carcinomas. ORL Otolaryngology and Related Specialties, 44: 323–334.CrossRefGoogle Scholar
Syrjanen, K. L., Syrjanen, S. M. (1987) Human papillomavirus DNA in bronchial squamous cell carcinoma. Lancet, i (8525): 168–169.Google Scholar
Zur Hausen, H. (1977) Human papilloma viruses and their possible role in squamous cell carcinoma. Current Topics in Microbiology and Immunology, 78: 1–30.Google Scholar
Zur Hausen, H. (1986) Intracellular surveillance of persisting viral infections. Lancet, ii: 489–491.CrossRefGoogle Scholar