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Histopathology of the stapes in osteogenesis imperfecta

Published online by Cambridge University Press:  29 June 2007

Ulrik Pedersen ,
Flemming Melsen ,
Ole Elbrønd  and
Peder Charles
Ulrik Pedersen*
Affiliation:
University Departments of Otorhinolaryngology
Flemming Melsen
Affiliation:
Aarhus Kommunehospital, and theUniversity Institute of Pathology, Aarhus Amtssygehus, Aarhus, Denmark.
Ole Elbrønd
Affiliation:
University Departments of Otorhinolaryngology
Peder Charles
Affiliation:
Nuclear Medicine
*
ENT Department, Aarhus kommunehospital, DK-8000, Aarhus C, Denmark.
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Summary

Conventional histological studies of stapes footplates from patients with osteogenesis imperfecta revealed, in nine out of 15 stapes examined, an otospongiotic-like lesion. Although the morphology of the stapedial lesion was comparable to the early otosclerotic focus, a greater structural disorganization and larger resorption spaces in osteogenesis imperfecta distinguished the two conditions. The histopathology of the stapes was related to the morphology of cortical and trabecular bone from the iliac crest. Various degrees of immature, osteogenic bony tissue were found in the iliac crest, showing no resemblance to the otospongiotic-like focus in the footplate. Even though the histologic appearance of the stapes footplates differed from the findings in peripheral bone, the present study indicates that the stapedial lesion in osteogenesis imperfecta is most likely a manifestation of the generalized bone and connective tissue disorder. The study further supports the view that osteogenesis imperfecta and otosclerosis are of different aetiology.

Type
Research Article
Information
The Journal of Laryngology & Otology , Volume 99 , Issue 5 , May 1985 , pp. 451 - 458
Copyright
Copyright © JLO (1984) Limited 1985

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References

Altmann, F., and Kornfeld, M. (1967) Osteogenesis imperfecta and otosclerosis: New investigations. Annals of Otology, Rhinology and Laryngology, 76: 89–104.Google Scholar
Bergstrom, L., Hemenway, W. G., and Sando, I. (1972) Pathological changes in congenital deafness. Laryngoscope, 82: 1777–1792.CrossRefGoogle ScholarPubMed
Bretlau, P. (1973) Otosklerose. Histopatologiske undersogelser af det otosclerotiske focus. Thesis. F.A.D.L. Copenhagen.Google Scholar
Bretlau, P., and Jørgensen, M. B. (1968) Histological investigations of otosclerotic foci. Acta Oto-Laryngologica, 65: 413–419.CrossRefGoogle ScholarPubMed
Bretlau, P., and Jørgensen, M. B. (1969) Otosclerosis and Osteogenesis imperfecta. Archives of Otolaryngology, 90: 4–10.CrossRefGoogle ScholarPubMed
Bretlau, P., Jørgensen, M. B., and Johansen, H. (1970) Osteogenesis imperfecta. Light and electron microscopic studies of the stapes. Acta Oto-Laryngologica, 69: 172–184.CrossRefGoogle ScholarPubMed
Brosnan, M., Burns, H., Jahn, A. F., and Hawke, M. (1977) Surgery and histopathology of the stapes in osteogenesis imperfecta tarda. Archives of Otolaryngology, 103: 294–298.CrossRefGoogle ScholarPubMed
Bullough, P. G., Davidson, D. D., and Lorenzo, J. C. (1981) The morbid anatomy of the skeleton in osteogenesis imperfecta. Clinical Orthopaedics and related research, 159: 42–57.CrossRefGoogle Scholar
Chevance, L. G. (1964) On some histochemical aspects of the otosclerotic focus. State and significance of the sulfhydryl groups. Acta Oto-Laryngologica, 58: 175–182.CrossRefGoogle ScholarPubMed
Chevance, L. G. (1965) Compairison des lésions histologiques de la platine stapédienne au cours de (osteogenesis imperfecta et de l'otospongiose). Problemes Actuels d Oto-Rhino-Laryngologie, pp. 150–158.Google Scholar
Falvo, K. A., and Bullough, P. G. (1973) Osteogenesis imperfecta: A histometric analysis. Journal of Bone and Joint surgery, American Volume, 55a: 275–286.CrossRefGoogle Scholar
Flintoff, W. M., Karmody, C. S., and Rabuzzi, D. D. (1976) Osteogenesis imperfecta of the stapes: An histological study. Journal of Otolaryngology, 5: 37–41.Google ScholarPubMed
Friedmann, I. (1974) Pathology of the ear. Blackwell Scientific Publications, pp. 245–278.Google Scholar
Hall, J. G., and Røhrt, T. (1968) The stapes in osteogenesis imperfecta. Acta Oto-Laryngologica, 65: 345–348.CrossRefGoogle ScholarPubMed
Hall, S., and Ogilvie, R. F. (1961) Otosclerosis in osteogenesis imperfecta. Acta Oto-Laryngologica, 53: 202–206.Google Scholar
Holdsworth, C. E., Endahl, G. L., Soifer, N., Richardson, K. E., and Eyring, E. J. (1973) Comparative biochemical study of otosclerosis and osteogenesis imperfecta. Archives of Otolaryngology, 98: 336–339.Google Scholar
Melsen, F. (1978) Histomorphometric analysis of iliac bone in normal and pathological conditions. (Thesis). University of Aarhus.Google Scholar
Morimitsu, T., and Hayashida, K. (1973) Surgical and histological findings of the stapes associated with Van der Hoeve's syndrome in a Japanese boy. Journal for oto-rhino-laryngology and its related specialities, 35: 342–349.Google Scholar
Ogilvie, R. F., and Hall, I. S. (1962) On the aetiology of otosclerosis. Journal of Laryngology and Otology, 76: 841–896.CrossRefGoogle ScholarPubMed
Opheim, O. (1968) Loss of hearing following the syndrome of Van der Hoeve-de Kleyn. Acta Oto-Laryngologica, 65: 337–344.CrossRefGoogle ScholarPubMed
Patterson, C. N., and IIIStone, H. B. (1970) Stapedectomy in Van der Hoeve's syndrome. Laryngoscope, 80: 544–558.CrossRefGoogle ScholarPubMed
Pedersen, U. (1984) Hearing loss in patients with osteogenesis imperfecta. A clinical and audiological study of 201 patients. Scandinavian Audiology, 13: 67–74.Google Scholar
Pedersen, U., and Elbrønd, O. (1983) Stapedectomy in osteogenesis imperfecta. Journal of Oto-Rhinolaryngology and Its Related Specialities, 45: 330–337.Google Scholar
Pedersen, U., Melsen, F., Kragstrup, J., and Charles, P. (1983) Histomorphometric analysis of iliac trabecular bone in otosclerosis. Acta Oto-Laryngologica, 97: 305–308.Google Scholar
Sando, I., Myers, D., Harada, T., Hinojosa, R., and Myers, E. N. (1981) Osteogenesis imperfecta tarda and otosclerosis. A temporal bone histopathology report. Annals of Otology, Rhinology and Laryngology, 90: 199–203.CrossRefGoogle ScholarPubMed
Schuknecht, H. F. (1974) Pathology of the ear. Harvard University Press, Cambridge, Massachusetts, U.S.A., pp.351–373.Google Scholar
Shea, J. J., Smyth, G. D. L., and Altmann, F. (1963) Surgical treatment of the hearing loss associated with osteogenesis imperfecta tarda. Journal of Laryngology and Otology, 77: 679–690.CrossRefGoogle ScholarPubMed
Wullstein, H., Ogilvie, R. F., and Hall, I. S. (1960) Van der Hoeve's syndrome in mother and daughters. Journal of Laryngology and Otology, 74: 67–83.CrossRefGoogle ScholarPubMed
Zajtchuk, J. T., and Lindsay, J. R. (1975) Osteogenesis imperfecta congenita and tarda: A temporal bone report. Annals of Otology, Rhinology and Laryngology, 84: 350–358.Google Scholar