Hostname: page-component-586b7cd67f-gb8f7 Total loading time: 0 Render date: 2024-11-29T16:57:58.082Z Has data issue: false hasContentIssue false
  • English
  • Français

Histopathological study of correlation between laryngeal space invasion and lymph node metastasis in glottic carcinoma

Published online by Cambridge University Press:  22 May 2009

H Chijiwa ,
K Sato ,
H Umeno  and
T Nakashima
H Chijiwa*
Affiliation:
Department of Otolaryngology-Head and Neck Surgery, Kurume University School of Medicine, Kurume, Japan
K Sato
Affiliation:
Department of Otolaryngology-Head and Neck Surgery, Kurume University School of Medicine, Kurume, Japan
H Umeno
Affiliation:
Department of Otolaryngology-Head and Neck Surgery, Kurume University School of Medicine, Kurume, Japan
T Nakashima
Affiliation:
Department of Otolaryngology-Head and Neck Surgery, Kurume University School of Medicine, Kurume, Japan
*
Address for correspondence: Dr Hideki Chijiwa, Department of Otolaryngology-Head and Neck Surgery, Kurume University School of Medicine, 67 Asahi-machi, Kurume 830-0011, Japan. Fax: +81 942 37 1200 E-mail: [email protected]
Get access Rights & Permissions [Opens in a new window]

Abstract

Objectives:

The paraglottic space and cricoid area of the larynx are made up of loose, areolar tissue composed of loose elastic and collagenous fibres and adipose tissue. They contain the main blood vessels of the larynx. We examined the correlation between the histopathological extension of glottic carcinoma into the paraglottic space or cricoid area and the development of cervical lymph node metastasis.

Study design:

We reviewed the medical charts of 45 patients (44 men and one woman) who had undergone total laryngectomy for squamous cell carcinoma of the glottis between 1991 and 2003.

Methods:

Macroscopic and microscopic study of the removed larynges of the same patients was performed, and the histopathological evidence for invasion of the paraglottic space or cricoid area was analysed.

Results:

Eight of the 24 patients (33 per cent) with invasion of the paraglottic space or cricoid area had cervical lymph node metastasis. In contrast, only one of the 21 patients (5 per cent) without any evidence of invasion of either space had lymph node metastasis. This difference was statistically significant (p < 0.05). In the 36 patients free of cervical lymph node metastasis, recurrence in the neck occurred in six (38 per cent) of the 16 patients with paraglottic space or cricoid area invasion, but in only one (5 per cent) of the 20 patients without paraglottic space or cricoid area invasion (p < 0.05).

Conclusion:

In patients with glottic carcinoma, invasion of cancer into the paraglottic space or cricoid area is an important prognostic factor for the development of cervical lymph node metastasis.

Keywords

Laryngeal SpaceParaglottic SpaceCricoid AreaLymph Node MetastasisGlottic Carcinoma
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 123 , Supplement S31 , May 2009 , pp. 48 - 51
Copyright
Copyright © JLO (1984) Limited 2009

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1Sato, K. Three dimensional anatomy of the larynx. Investigation by whole organ sections. Otologia Fukuoka 1987;33:153–82Google Scholar
2Asimov, I, Bassett, DL, Beamer, PR, Bean, WB, Benedict, WL et al. Stedman's Medical Dictionary, 21st edn.Baltimore: Williams & Wilkins, 1966;1479Google Scholar
3Tucker, GF, Smith, HR. A histological demonstration of the development of laryngeal connective tissue compartments. Trans Am Acad Opthal Otolaryngol 1962;66:308–18Google ScholarPubMed
4Hirano, M, Sato, K. Histological Color Atlas of the Human Larynx. San Diego: Singular Publishing, 1993Google Scholar
5Sato, K, Kurita, S, Hirano, M. Location of the pre-epiglottic space and its relationship to the paraglottic space. Ann Otol Rhinol Laryngol 1993;102:930–4CrossRefGoogle Scholar
6Chijiwa, H, Umeno, T, Sato, K, Nakashima, T. Histopathological study of the correlation between the laryngeal space extension and cervical lymph node metastasis in supraglottic carcinomas [in Japanese]. Larynx Jpn 2003;15;19–22CrossRefGoogle Scholar
7Pressman, JJ, Simon, MB, Monell, C. Anatomical studies related to the dissemination of cancer of the larynx. Trans Am Acad Opthal Otolaryngol 1960;64:628–38Google Scholar
8Sato, K, Umeno, T, Hirano, M et al. Cricoid area of the larynx: its physiological and pathological significance. Acta Otolaryngol 2002;122:882–6CrossRefGoogle ScholarPubMed
9Umeno, T, Sato, K, Matsuda, Y, Nakashima, T. Clinicopathological study of stomal recurrence following total laryngectomy [in Japanese]. J Jpn Bronchoesophagol Soc 2001;52:438–46CrossRefGoogle Scholar