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Histopathological changes of nasal mucosa after nasal packing with Merocel

Published online by Cambridge University Press:  20 December 2021

M Tan Open the ORCID record for M Tan [Opens in a new window] ,
T Bayındır ,
M T Çiçek ,
M Aslan Open the ORCID record for M Aslan [Opens in a new window]  and
M Gül
M Tan*
Affiliation:
Department of Otorhinolaryngology, Inonu University Medical Faculty, Malatya, Turkey
T Bayındır
Affiliation:
Department of Otorhinolaryngology, Inonu University Medical Faculty, Malatya, Turkey
M T Çiçek
Affiliation:
Department of Otorhinolaryngology, Inonu University Medical Faculty, Malatya, Turkey
M Aslan
Affiliation:
Department of Otorhinolaryngology, Inonu University Medical Faculty, Malatya, Turkey
M Gül
Affiliation:
Department of Histology, Inonu University Medical Faculty, Malatya, Turkey
*
Author for correspondence: Dr Mehmet Tan, Department of Otorhinolaryngology, Inonu University Medical Faculty, Malatya, Turkey E-mail: [email protected]
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Abstract

Objective

To determine histopathological changes in nasal mucosa associated with duration of nasal packing with Merocel tampons.

Methods

This study included 24 healthy rabbits, 6 rabbits per group. In group A, no tampon was applied. In group B, Merocel nasal tampons were applied and removed after 24 hours. In group C, the tampons were removed after 48 hours. In group D, the tampons were removed after 5 days. Specimens were obtained from the septum of each rabbit, including cartilage. Histopathological examination was performed.

Results

Significant differences were observed in terms of inflammatory infiltration and loss of cilia between groups A and B. Significant differences were also observed in terms of inflammatory infiltration, haematoma, cilia loss, epithelium dysplasia and cartilage degeneration between groups B and C. There were significant differences in terms of cilia loss, epithelium dysplasia and subepithelial fibrosis between groups C and D. Cartilage degeneration was mild in one animal in group B and in two animals in group C, and was moderate in four animals in group C.

Conclusion

It is recommended that Merocel nasal tampons are removed within 48 hours to preserve nasal mucosal function. Keeping the pack longer may cause cartilage degeneration and other complications.

Keywords

EpistaxisSeptoplastyNasal Packing
Type
Main Article
Information
The Journal of Laryngology & Otology , Volume 136 , Issue 8 , August 2022 , pp. 750 - 754
Copyright
Copyright © The Author(s), 2021. Published by Cambridge University Press on behalf of J.L.O. (1984) LIMITED

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Footnotes

Dr M Tan takes responsibility for the integrity of the content of the paper

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