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Head and neck squamous cell cancer associated with lymphoproliferative malignancies is aggressive

Published online by Cambridge University Press:  20 April 2020

L Li ,
L Hamilton ,
J Montgomery  and
M Stewart
L Li*
Affiliation:
Department of Otolaryngology, Queen Elizabeth University Hospital, Glasgow, Scotland, UK
L Hamilton
Affiliation:
Department of Otolaryngology, Queen Elizabeth University Hospital, Glasgow, Scotland, UK
J Montgomery
Affiliation:
Department of Otolaryngology, Queen Elizabeth University Hospital, Glasgow, Scotland, UK
M Stewart
Affiliation:
Department of Otolaryngology, Queen Elizabeth University Hospital, Glasgow, Scotland, UK
*
Author for correspondence: Dr Lucy Li, Department of Otolaryngology, Queen Elizabeth University Hospital, GlasgowG51 4TF, Scotland, UK E-mail: [email protected]
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Abstract

Background

Patients with non-Hodgkin's lymphoma and chronic lymphocytic leukaemia are at an elevated risk of further malignancy. Head and neck squamous cell carcinoma often presents with cervical lymph node metastasis, and can pose a diagnostic challenge in patients with non-Hodgkin's lymphoma or chronic lymphocytic leukaemia who may have pre-existing palpable neck nodes.

Methods

A retrospective case review of a health board was conducted to identify patients with head and neck squamous cell carcinoma with a previous diagnosis of non-Hodgkin's lymphoma or chronic lymphocytic leukaemia.

Results

Four patients with head and neck squamous cell carcinoma that developed after non-Hodgkin's lymphoma or chronic lymphocytic leukaemia were identified. Two patients had a background of non-Hodgkin's lymphoma treated with chemotherapy. The remaining two patients had a background of chronic lymphocytic leukaemia under active surveillance. Three out of the four patients died within 30 months of diagnosis.

Conclusion

Head and neck squamous cell carcinoma following non-Hodgkin's lymphoma or chronic lymphocytic leukaemia is aggressive. A heightened clinical suspicion is essential to facilitate early diagnosis and treatment of head and neck squamous cell carcinoma in patients with dual pathology.

Keywords

Metachronous NeoplasmsSquamous Cell Carcinoma Of Head And NeckHuman Papilloma VirusChronic Lymphocytic LeukemiaNon-Hodgkin's Lymphoma
Type
Clinical Records
Information
The Journal of Laryngology & Otology , Volume 134 , Issue 5 , May 2020 , pp. 460 - 462
Copyright
Copyright © JLO (1984) Limited, 2020

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Footnotes

Dr L Li takes responsibility for the integrity of the content of the paper

References

Dong, C, Hemminki, K. Second primary neoplasms among 53 159 haematolymphoproliferative malignancy patients in Sweden, 1958-1996: a search for common mechanisms. Br J Cancer 2001;85:997–1005CrossRefGoogle ScholarPubMed
Mudie, NY, Swerdlow, AJ, Higgins, CD, Smith, P, Qiao, Z, Hancock, BW et al. Risk of second malignancy after non-Hodgkin's lymphoma: a British Cohort Study. J Clin Oncol 2006;24:1568–74CrossRefGoogle ScholarPubMed
Brennan, P, Scélo, G, Hemminki, K, Mellemkjaer, L, Tracey, E, Andersen, A et al. Second primary cancers among 109 000 cases of non-Hodgkin's lymphoma. Br J Cancer 2005;93:159–66CrossRefGoogle ScholarPubMed
Schöllkopf, C, Rosendahl, D, Rostgaard, K, Pipper, C, Hjalgrim, H. Risk of second cancer after chronic lymphocytic leukemia. Int J Cancer 2007;121:151–6CrossRefGoogle ScholarPubMed
Petrakova, K, Vyskocil, J, Grell, P, Majek, O, Soumarova, R, Novak, J et al. . Second cancers in Hodgkin's lymphoma long-term survivals: a 60-year single institutional experience with real-life cohort of 871 patients. Int J Clin Pract 2018:e13235CrossRefGoogle ScholarPubMed
Moertel, CG. Multiple primary malignant neoplasms: historical perspectives. Cancer 1977;40:1786–9210.1002/1097-0142(197710)40:4+<1786::AID-CNCR2820400803>3.0.CO;2-23.0.CO;2-2>CrossRefGoogle ScholarPubMed
DePeña, CA, Van Tassel, P, Lee, YY. Lymphoma of the head and neck. Radiol Clin North Am 1990;28:723–43Google ScholarPubMed
Joo, Y-H, Jung, C-K, Sun, D-I, Kim, M-S. Synchronous laryngeal squamous cell carcinoma and Hodgkin lymphoma of the head and neck region. Auris Nasus Larynx 2009;36:501–410.1016/j.anl.2008.10.012CrossRefGoogle ScholarPubMed
Perez-Reyes, N, Farhi, DC. Squamous cell carcinoma of head and neck in patients with well-differentiated lymphocytic lymphoma. Cancer 1987;59:540–43.0.CO;2-U>CrossRefGoogle ScholarPubMed
Stack, BC, Ridley, MB, Endicott, JN. Simultaneous squamous cell carcinoma of the head and neck and reticuloendothelial malignancies. Am J Otolaryngol 1996;17:178–8310.1016/S0196-0709(96)90057-5CrossRefGoogle ScholarPubMed
Watanabe, N, Inohara, H, Akahani, S, Yamamoto, Y, Moriwaki, K, Kubo, T. Synchronous squamous cell carcinoma and malignant lymphoma in the head and neck region. Auris Nasus Larynx 2007;34:273–610.1016/j.anl.2006.07.002CrossRefGoogle ScholarPubMed
Hammami, B, Mnejja, M, Achour, I, Chakroun, A, Khabir, A, Chakroun, A et al. Association of squamous cell carcinoma of the larynx and chronic lymphoid leukemia. Eur Ann Otorhinolaryngol Head Neck Dis 2010;127:153–5CrossRefGoogle ScholarPubMed
McElroy, C, Velilla, R, Chaudhary, H, Al-Abbadi, MA. Fine-needle aspiration diagnosis of squamous cell carcinoma in a lymph node involved with small lymphocytic lymphoma: case report and review of the literature. Diagn Cytopathol 2009;37:48–5010.1002/dc.20955CrossRefGoogle Scholar
Minca, EC, Popat, SR, Chadha, MK, Merzianu, M. Small lymphocytic lymphoma obscuring microscopic tonsillar squamous cell carcinoma: an unknown occurrence with a known primary. Head Neck Pathol 2012;6:125–9CrossRefGoogle ScholarPubMed
Katou, A, Hirohata, H, Uchida, F, Takeuchi, Y, Yamato, M, Ishibashi-Kanno, N et al. A rare case of synchronous squamous cell carcinoma on the body of the tongue and malignant lymphoma of the neck. J Dents Dent Med 2018;1:110Google Scholar
Singh, NJ, Tripathy, N, Roy, P, Manikantan, K, Arun, P. Simultaneous triple primary head and neck malignancies: a rare case report. Head Neck Pathol 2016;10:233–6CrossRefGoogle ScholarPubMed
Tezer, MS, Tuncel, U, Uzlugedik, S, Uzun, M, Kulaçoğlu, S, Unal, A. Coexistence of laryngeal squamous cell carcinoma and non-Hodgkin's lymphoma with nasopharyngeal involvement. J Laryngol Otol 2006;120:e210.1017/S0022215105000782CrossRefGoogle ScholarPubMed
Boddie, AW, Goepfert, H, Fischer, EP, Ballantyne, AJ. Head and neck cancer developing in patients with pre-existing reticuloendothelial malignancies. Laryngoscope 1977;87:2090–5CrossRefGoogle ScholarPubMed
Mullen, JL, Reichman, J, Rosato, EF. Multiple carcinomas following therapy for Hodgkin disease. J Surg Oncol 1979;11:75–810.1002/jso.2930110113CrossRefGoogle ScholarPubMed
Bakri, K, Shimaoka, K, Rao, U, Tsukada, Y. Adenosquamous carcinoma of the thyroid after radiotherapy for Hodgkin's disease. A case report and review. Cancer 1983;52:465–70Google ScholarPubMed
Sobin, LH, Gospodarowicz, MK, Wittekind, C, eds. TNM Classification of Malignant Tumours, 7th edn. Chichester: Wiley-Blackwell, 2009Google Scholar
Kader, I, Leavers, B, Shashinder, S, Wylie, B, Chi, K-K, Sundaresan, P. Synchronous or metachronous lymphoma and metastatic cutaneous squamous cell carcinoma in the head and neck region: a diagnostic and management dilemma. J Laryngol Otol 2016;130(suppl 4):S45–910.1017/S002221511600832XCrossRefGoogle ScholarPubMed
van Leeuwen, FE, Klokman, WJ, Hagenbeek, A, Noyon, R, van den Belt-Dusebout, AW, van Kerkhoff, EH, et al. Second cancer risk following Hodgkin's disease: a 20-year follow-up study. J Clin Oncol 1994;12:312–2510.1200/JCO.1994.12.2.312CrossRefGoogle ScholarPubMed
Morgan, RL, Eguchi, MM, Mueller, AC, Daugherty, SL, Amini, A, Karam, SD. Imaging at diagnosis impacts cancer-specific survival among patients with cancer of the oropharynx. Cancer 2019;125:2794–802Google ScholarPubMed
Reusser, N, Downing, C, Guidry, J, Tyring, S. HPV carcinomas in immunocompromised patients. J Clin Med 2015;4:260–81CrossRefGoogle ScholarPubMed
Tay, GC-A, Iyer, NG, Ong, W-S, Tai, D, Ang, M-K, Ha, TC et al. . Outcomes and prognostic factors of radiation-induced and de novo head and neck squamous cell carcinomas. Otolaryngol Head Neck Surg 2016;154:880–710.1177/0194599816631726CrossRefGoogle ScholarPubMed
Levi, F, Randimbison, L, Te, VC, La Vecchia, C. Non-Hodgkin's lymphomas, chronic lymphocytic leukaemias and skin cancers. Br J Cancer 1996;74:1847–5010.1038/bjc.1996.642CrossRefGoogle ScholarPubMed
Barker, HE, Paget, JTE, Khan, AA, Harrington, KJ. The tumour microenvironment after radiotherapy: mechanisms of resistance and recurrence. Nat Rev Cancer 2015;15:409–25CrossRefGoogle ScholarPubMed
Paksoy, N, Ozbek, B. Cytopathologist-performed and ultrasound-guided fine needle aspiration cytology enhances diagnostic accuracy and avoids pitfalls: an overview of 20 years of personal experience with a selection of didactic cases. Cytojournal 2018;15:8CrossRefGoogle ScholarPubMed