Hostname: page-component-586b7cd67f-vdxz6 Total loading time: 0 Render date: 2024-11-23T03:23:50.204Z Has data issue: false hasContentIssue false
  • English
  • Français

Genetics of otosclerosis

Published online by Cambridge University Press:  29 June 2007

R. Sabitha ,
Ravi Ramalingam ,
K. K. Ramalingam ,
T. A. Sivakumaran  and
A. Ramesh
R. Sabitha
Affiliation:
Department of Genetics, Dr ALM PGIBMS, Taramani, Madras.
Ravi Ramalingam
Affiliation:
K. K. R. ENT Hospital and Research Institute, 827, Poonamallee High Road, Kilpauk, Madras 600 010, India.
K. K. Ramalingam
Affiliation:
K. K. R. ENT Hospital and Research Institute, 827, Poonamallee High Road, Kilpauk, Madras 600 010, India.
T. A. Sivakumaran
Affiliation:
Department of Genetics, Dr ALM PGIBMS, Taramani, Madras.
A. Ramesh*
Affiliation:
Department of Genetics, Dr ALM PGIBMS, Taramani, Madras.
*
Address for correspondence: Dr A. Ramesh, Department of GeneticsDr ALMPGIBMS, Taramani, Madras 600 113, India. Fax: 91-044-4926709
Get access Rights & Permissions [Opens in a new window]

Abstract

Otosclerosis is an early-middle adult life genetic disease affecting bone remodelling in the ear. Current knowledge of otosclerosis as an inherited disease dates to the mid-19th century, and we report here an attempt to understand the genetics of otosclerosis and detect its heterogeneity. The analysis was conducted on 151 otosclerotic families. The results of our study indicate that while heredity plays an important role in the manifestation of the disease a substantial portion of otosclerotic cases could arise due to non-genetic causes.

Keywords

Otoscierosisgenetics
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 111 , Issue 2 , February 1997 , pp. 109 - 112
Copyright
Copyright © JLO (1984) Limited 1997

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Footnotes

This work was presented at the Seminar on Genetic Epidemiology and XX Annual Conference of Indian Society of Human Genetics held December 11–13, 1994, at the Department of Genetics, Osmania University, Hyderabad – 7.

References

Brobby, G. W. (1986) Two cases of otosclerosis in Kumasi, Ghana. Tropical Geographic Medicine 38: 292–295.Google ScholarPubMed
Cavalli-Sforza, L. L., Bodmer, W. F. (1971) The Genetics of Human Populations. 2nd EditionW. H. F. Freeman Company, San Francisco, pp 851–866.Google Scholar
Causse, J. R., Causse, J. B. (1984) Otospongiosis as a genetic disease: early detection management and prevention. American Journal of Otology 5: 211–223.Google ScholarPubMed
Hall, J. G. (1974) Otosclerosis in Norway: geographic and genetic study. Acta Otolaryngologica 108: 544–549.Google Scholar
James, W. H. (1989) Sex ratios in otosclerotic families. Journal of Laryngology and Otology 103: 1036–1039.CrossRefGoogle ScholarPubMed
James, W. H. (1991) Sex ratios of probands and secondary cases in conditions of multifactorial inheritance where liability varies with sex. Journal of Medical Genetics 28: 41–43.CrossRefGoogle ScholarPubMed
Kapur, Y. P., Patt, A. J. (1967) Hearing in Todas of S. India. Archives of Otolaryngology 85: 74–80.Google Scholar
Larsson, A. (1962) Genetic problems in otoscierosis. In: Otosclerosis. 1st Edition (Schuknecht, , eds.) Little, Brown and Company, Boston, Mass. pp 109–117.Google Scholar
Ludman, H. (1988) Otosclerosis. In Mawson's Diseases of the Ear. 5th Edition. Edward Arnold Company, Great Britain, pp 562–582.Google Scholar
McKay, K. (1986) Non-inflammatory middle - ear diseases. In Logan Turner Diseases of the Nose, Throat and Ear (Birell, J. F., ed.) K. M. Varghese Company, Bombay, pp 387–391.Google Scholar
McPhee, J. R., Gordon, M. A., Ruben, R. J., Van de Water, T. R. (1993) Evidence of abnormal stromelysin mRNA expression in suspected carriers of otosclerosis. Archives of Otolaryngology, Head and Neck Surgery 119: 1108–1116.CrossRefGoogle ScholarPubMed
Michael, A. G. (1989) The genetics of otoscierosis. A review. American Journal of Otology 10 (6): 426–438.Google Scholar
Morrison, A. W. (1967) Genetic factors in otoscierosis. Annals of the Royal College of Surgeons of England 47: 202–237.Google Scholar
Rajendra Kumar, P. V. (1975) Deafness in tropics. In ENT Diseases in Tropical Environment. (Kameswaran, , ed.) Higginbothams Pvt Ltd, Madras. pp 129–149.Google Scholar
Raman, R., Mathews, J., Idikula, J. (1991) Obliterative otosclerosis. Journal of Laryngology and Otology 105: 899–900.CrossRefGoogle ScholarPubMed