Hostname: page-component-586b7cd67f-rcrh6 Total loading time: 0 Render date: 2024-11-23T03:04:50.208Z Has data issue: false hasContentIssue false
  • English
  • Français

Fine needle aspiration in the pre-operative diagnosis of melanotic neuroectodermal tumour of infancy

Published online by Cambridge University Press:  29 June 2007

H. Galera-Ruiz ,
D. Gomez-Angel ,
F. J. Vazquez-Ramirez ,
J. C. Sanguino-Fabre ,
C. I. Salazar-Fernandez  and
J. Gonzalez-Hachero
H. Galera-Ruiz*
Affiliation:
Otolaryngology – Head and Neck Surgery Service, University of Seville, School of Medicine, Seville, Spain.
D. Gomez-Angel
Affiliation:
Otolaryngology – Head and Neck Surgery Service, University of Seville, School of Medicine, Seville, Spain.
F. J. Vazquez-Ramirez
Affiliation:
Department of Pathology, University of Seville, School of Medicine, Seville, Spain.
J. C. Sanguino-Fabre
Affiliation:
Department of Pediatrics, University of Seville, School of Medicine, Seville, Spain.
C. I. Salazar-Fernandez
Affiliation:
Oral Maxillofacial Surgery Service, University of Seville, School of Medicine, Seville, Spain.
J. Gonzalez-Hachero
Affiliation:
Department of Pediatrics, University of Seville, School of Medicine, Seville, Spain.
*
Address for correspondence: Dr Hugo Galera-Ruiz, Avda. Cañada de la viña n°75, 41927 Mairena del Aljarafe, Sevilla Spain. Fax: 34-5-4371284
Get access Rights & Permissions [Opens in a new window]

Abstract

A case of melanotic neuroectodermal tumour of infancy is decribed. The pre-operative diagnosis was made on cytological material obtained by fine needle aspiration. The patient was a three-month-old male infant with a rapidly growing maxillary tumour mass that also involved the pterygomaxillary fossae and the floor of the orbit. In addition to the typical clinical presentation, the cytology is also distinctive showing a dual population of small neuroblastic cells and large melanin-containing epithelial cells. Histological, immunohistochemical and electron microscopic examination of the excised mass confirmed the initial diagnosis. The pre-operative distinction of this tumour from other small round cell tumours of infancy (rhabdomyosarcoma, neuroblastoma, melanoma and lymphoma), is essential in order to plan the most complete resection therefore reducing the possibilities of tumour recurrence. This tumour belongs to a field of pathology with which many otolaryngologists may not be familiar.

Keywords

Maxillary neoplasmsCytodiagnosisImmunohistochemistry
Type
Pathology in Focus
Information
The Journal of Laryngology & Otology , Volume 113 , Issue 6 , June 1999 , pp. 581 - 584
Copyright
Copyright © JLO (1984) Limited 1999

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Argenyi, Z. B., Schelper, R. L., Balogh, K. (1991) Pigmented neuroectodermal tumour of infancy. A light microscopic and immunohistochemical study. Journal of Cutaneous Pathology 18: 40–45.CrossRefGoogle Scholar
Borello, D. E., Gorlin, R. J. (1966) Melanotic neuroectodermal tumour of infancy: a neoplasm of neural crest origin. Report of a case associated with a high urinary excretion of vanilmandelic acid. Cancer 19: 196–206.3.0.CO;2-6>CrossRefGoogle Scholar
Calabrese, F., Danieli, D., Valente, M. (1995) Melanotic neuroectodermal tumour of the epididymis in infancy: case report and review of the literature. Urology 46: 415–418.Google ScholarPubMed
Crocket, D. M., McGill, T. J., Healy, G. B., Friedman, D. M. (1987) Melanotic neuroectodermal tumour of infancy. Otolaryngology – Head and Neck Surgery 96: 194–197.CrossRefGoogle Scholar
Cutler, L. S., Chaudhry, A. P., Topazian, R. (1981) Melanotic neuroectodermal tumour of infancy: an ultrastructural study, literature review, and reevaluation. Cancer 48: 257–270.3.0.CO;2-1>CrossRefGoogle ScholarPubMed
Denher, L. P., Sibley, R. K., Sauk, J. Jr., Vickers, R. A., Nesbit, M. E., Leonard, A. S., Waite, D. E., Neeley, J. E., Ophoven, J. (1979) Malignant melanotic neuroectodermal tumour of infancy. A clinical, pathologic, ultrastructural and tissue culture study. Cancer 43: 1389–1410.Google Scholar
Hahn, J. F., Sperber, E. E., Netsky, M. G. (1976) Melanotic neuroectodermal tumours of the brain and skull. Journal of Neuropathological Experimental Neurology 35: 508–519.CrossRefGoogle ScholarPubMed
Irving, R. M., Parikh, A., Coumbe, A., Albert, D. M. (1993) Melanotic neuroectodermal tumour of infancy. Journal of Laryngology and Otology 107: 1045–1048.CrossRefGoogle ScholarPubMed
Judd, P. J., Pedod, D., Harrop, K., Becker, J. (1990) Melanotic neuroectodermal tumour of infancy. Oral Surgery, Oral Medicine, Oral Pathology 69: 723–726.CrossRefGoogle Scholar
Kapadia, S. B., Frisman, D. M., Hitchcock, C. L., Popek, E. J. (1993) Melanotic neuroectodermal tumour of infancy. Clinicopathological, immunohistochemical and flow cytometric study. American Journal of Surgical Pathology 17: 566–573.CrossRefGoogle ScholarPubMed
Krompecher, E. (1918) Zur Histogenese und Morphologie der Adamantinome und Sonstiger Kiefergeschwulste. Beitrage zur Pathologischen Anatomie und zur Allgemeinen Pathologie 64: 165–197.Google Scholar
Mirich, D. R., Blaser, S. I., Harwood-Nash, D. C. (1991) Melanotic neuroectodermal tumour of infancy: clinical, radiologic, and pathologic findings in five cases. American Journal of Neuroradiology 12: 689–697.Google ScholarPubMed
Misugi, K., Okajima, H., Newton, W. A. Jr., Kemtz, D. R., de Lorimier, A. A. (1965) Mediastinal origin of a melanotic progonoma or retinal anlage tumour. Ultrastructural evidence for neural crest origin. Cancer 18: 477–484.3.0.CO;2-N>CrossRefGoogle ScholarPubMed
Navas Palacios, J. J. (1980) Malignant melanotic neuroectodermal tumour. Light and electron microscopic study. Cancer 46: 529–536.3.0.CO;2-4>CrossRefGoogle ScholarPubMed
Pettinato, G., Manivel, J. C., d'Amore, E. S., Jaszcz, W., Gorlin, R. J. (1991) Melanotic neuroectodermal tumour of infancy. A re-examination of a histogenetic problem based on immunohistochemical, flow cytometric, and ultrastructural study of 10 cases. American Journal of Surgical Pathology 15: 223–245.CrossRefGoogle Scholar
Rao, C. R., Visweshwaraiah, L. D., Veerapaiah, K. S., Satpute, S. D., Hazarika, D., Bhargava, M. K. (1990) Melanotic neurectodermal tumour of infancy initially diagnosed by fine needle aspiration cytology. Acta Cytologica 34: 681–684.Google Scholar
Scheck, O., Ruck, P., Harms, D., Kaiserling, E. (1989) Melanotic neuroectodermal tumour of infancy occurring in the left thigh of a six-month-old female infant. Ultrastructural Pathology 13: 23–33.CrossRefGoogle Scholar
Sobel, N., Carcangiu, M. L. (1994) Primary pigmented neuroectodermal tumour of the uterine cervix. International Journal of Surgical Pathology 2: 31–36.CrossRefGoogle Scholar
Stirling, R. W., Powell, G., Fletcher, C. D. M. (1988) Pigmented neuroectodermical tumour of infancy: An immunohistochemical study. Histopathology 12: 425–435.CrossRefGoogle Scholar
Toda, T., Sadi, A. M., Kiyuna, M. Egawa, H., Tamamoto, T., Toyoda, Z. (1996) Pigmented neuroectodermal tumour of infancy of the epididymis. A case report. Acta Cytologica 42: 775–780.Google Scholar