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Extrapulmonary small cell carcinoma in head and neck

Published online by Cambridge University Press:  23 February 2015

R Yasumatsu ,
T Nakashima ,
M Yamauchi ,
S Toh  and
S Komune
R Yasumatsu*
Affiliation:
Department of Otorhinolaryngology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
T Nakashima
Affiliation:
Department of Otorhinolaryngology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
M Yamauchi
Affiliation:
Department of Otorhinolaryngology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
S Toh
Affiliation:
Department of Otorhinolaryngology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
S Komune
Affiliation:
Department of Otorhinolaryngology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
*
Address for correspondence: Ryuji Yasumatsu, Department of Otorhinolaryngology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan Fax: + 81926425685 E-mail: [email protected]
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Abstract

Purpose:

The management of extrapulmonary small cell carcinoma has not been standardised to date. This study reviewed the clinical course, management and survival outcomes of patients with extrapulmonary small cell carcinoma in the head and neck region.

Methods:

Nine patients with extrapulmonary small cell carcinoma in the head and neck were included in this study.

Results:

Five patients received radical surgery followed by adjuvant chemotherapy or radiotherapy or both. Two other patients were treated with chemotherapy consisting of CPT11 plus cisplatin or CPT11 plus cisplatin plus VP-16 three times. Two other patients received chemoradiotherapy consisting of S-1 or CPT11 plus cisplatin. The median overall survival was 14.5 months, with a three-year survival rate of 23.7 per cent.

Conclusions:

The prognosis of extrapulmonary small cell carcinoma is generally poor. Further prospective multicentre studies are required for better understanding of disease entities and response to treatment modalities.

Keywords

Extrapulmonary Small-Cell CarcinomaHead and NeckTreatment
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 129 , Issue S2 , March 2015 , pp. S83 - S85
Copyright
Copyright © JLO (1984) Limited 2015 

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References

1van der Heijden, HF, Heijdra, YF. Extrapulmonary small cell carcinoma. South Med J 2005;98:345–9Google Scholar
2Walenkamp, AM, Sonke, GS, Sleijfer, DT. Clinical and therapeutic aspects of extrapulmonary small cell carcinoma. Cancer Treat Rev 2009;35:228–36CrossRefGoogle ScholarPubMed
3Ferlito, A. Diagnosis and treatment of small cell carcinoma of the larynx: a critical review. Ann Otol Rhinol Laryngol 1986;95:590–600CrossRefGoogle ScholarPubMed
4Remick, SC, Ruckdeschel, JC. Extrapulmonary and pulmonary small-cell carcinoma: tumor biology, therapy, and outcome. Med Pediatr Oncol 1992;20:89–99Google Scholar
5Lo Re, G, Canzonieri, V, Veronesi, A, Dal Bo, V, Barzan, L, Zancanaro, C, et al. Extrapulmonary small cell carcinoma: a single-institution experience and review of the literature. Ann Oncol 1994;5:909–13Google Scholar
6Brennan, SM, Gregory, DL, Stillie, A, Herschtal, A, Mac Manus, M, Ball, DL. Should extrapulmonary small cell cancer be managed like small cell lung cancer? Cancer 2010;116:888–895Google Scholar
7Cicin, I, Karagol, H, Uzunoglu, S, Uygun, K, Usta, U, Kocak, Z et al. Extrapulmonary small-cell carcinoma compared with small-cell lung carcinoma: a retrospective single-center study. Cancer 2007;110:1068–76CrossRefGoogle ScholarPubMed
8Weng, CT, Chu, PY, Liu, MT, Chen, MK. Small cell carcinoma of the head and neck: a single institution's experience and review of the literature. J Otolaryngol Head Neck Surg 2008;37:788–793Google ScholarPubMed
9Haider, K, Shahid, RK, Finch, D, Sami, A, Ahmad, I, Yadav, S et al. Extrapulmonary small cell cancer: a Canadian province's experience. Cancer 2006;107:2262–9Google Scholar
10Grossman, RA, Pedroso, FE, Byrne, MM, Koniaris, LG, Misra, S. Does surgery or radiation therapy impact survival for patients with extrapulmonary small cell cancers? J Surg Oncol 2011; 104:604–12Google Scholar
11Weiss, MD, deFries, HO, Taxy, JB, Braine, H. Primary small cell carcinoma of the paranasal sinuses. Arch Otolaryngol 1983;109:341–3CrossRefGoogle ScholarPubMed
12Kim, KO, Lee, HY, Chun, SH, Shin, SJ, Kim, MK, Lee, KH et al. Clinical overview of extrapulmonary small cell carcinoma. J Korean Med Sci 2006;21:833–7Google Scholar
13Ochsenreither, S, Marnitz-Schultze, S, Schneider, A, Koehler, C, Daum, S, Loddenkemper, C et al. Extrapulmonary small cell carcinoma (EPSCC): 10 years' multi-disciplinary experience at Charite. Anticancer Res 2009;29:3411–15Google ScholarPubMed