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Expression of carbonic anhydrase isoenzymes in the developing endolymphatic sac of the human fetus and the mouse embryo

Published online by Cambridge University Press:  29 June 2007

Hiroshi Yamashita ,
Dan Bagger-Sjöbäck  and
Toru Sekitani
Hiroshi Yamashita*
Affiliation:
Department of Otolaryngology, Karolinska Hospital, Karolinska Institute, Stockholm, Sweden.
Dan Bagger-Sjöbäck
Affiliation:
Department of Otolaryngology, Karolinska Hospital, Karolinska Institute, Stockholm, Sweden.
Toru Sekitani
Affiliation:
Department of Otolaryngology, Yamaguchi University School of Medicine, Ube, Japan.
*
Hiroshi Yamashita, M.D., Department of Otolaryngology, Yamaguchi University School of Medicine, Ube, Yamaguchi 755, Japan.
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Abstract

The distribution of carbonic anhydrase isoenzymes (CA) was analyzed in the developing endolymphatic sac (ES) of the mouse embryo and human fetus using immunohistochemical method. The primordial ES epithelium was labelled with CA I and CA II, but was weakly labelled with CA III and CA V. In the thirteenth and fifteenth gestational day (GD) mice, the ES epithelium was positive for CA I and CA II. After seventeenth GD, the ES epithelium was however weakly positive for CA I and CA II. In the 11 and 12 week old human fetus, the ES epithelium was strongly labelled with CA I and CA II. In the 16 week old human fetus, the ES epithelium was however weakly positive for CA I and CA II. These results suggest that the fetal ES has an activity of CA and plays a role in the otoconial formation especially in the early stage during evolution.

Keywords

Carbonic anhydraseEndolymphatic sacFetus, embryo
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 106 , Issue 2 , February 1992 , pp. 98 - 102
Copyright
Copyright © JLO (1984) Limited 1992

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