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Experimental study on neurorrhaphy of the recurrent laryngeal nerve in dogs

Published online by Cambridge University Press:  29 June 2007

A. Rubio ,
M. R. Fernández ,
J. Figols  and
J. Rama
A. Rubio*
Affiliation:
Department of Otorhinolaryngology, ‘Faculated de Medicina, Hospital Universitario Marqués de Valdecilla’, Santander, Spain
M. R. Fernández
Affiliation:
Department of Physiology, ‘Faculated de Medicina, Hospital Universitario Marqués de Valdecilla’, Santander, Spain
J. Figols
Affiliation:
Department of Pathology, ‘Faculated de Medicina, Hospital Universitario Marqués de Valdecilla’, Santander, Spain
J. Rama
Affiliation:
Department of Otorhinolaryngology, ‘Faculated de Medicina, Hospital Universitario Marqués de Valdecilla’, Santander, Spain
*
Address for correspondence: Antonio Rubio, M.D., Departmento de Otorrinolaringología, Hospital Universitario Marqués de Valdecilla, 39008 Santander, Spain. Fax: (942) 202655.
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Abstract

The effectiveness of anastomosis of a divided recurrent laryngeal nerve was evaluated in six adult mongrel dogs. Videolaryngoscopy and evoked compound muscle action potentials in the intrinsic laryngeal muscles were performed at six months and the posterior cricoarytenoid muscles and recurrent laryngeal nerves were processed for histomorphometric studies. Recovery of compound muscle action potentials in all re-innervated muscles and histomorphometric findings confirmed a good grade of axonal regeneration. The most significant histomorphometric changes observed were: a reactive hypertrophy of type I fibres in the posterior cricoarytenoid muscles of the re-innervated side, and a high nerve fibre density in the distal stump to the anastomosis. However, incomplete recovery of motion and fasciculated movements of the reinnervated vocal folds were observed. Reduction of effective motor units in the re-innervated muscles might be a factor that cause incomplete restoration of vocal fold movements.

Keywords

Recurrent laryngeal nerveAnastomosis, surgicalDogs
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 110 , Issue 8 , August 1996 , pp. 748 - 753
Copyright
Copyright © JLO (1984) Limited 1996

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Footnotes

This study was performed in accordance with the Policy on Humane Care and Use of Laboratory Animals; the animal use protocol was approved by the Department of Surgery and Medicine of ‘Universidad de Cantabria’.

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