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Evaluation of plasma fibronectine level as a probable indicator for tympanosclerosis

Published online by Cambridge University Press:  01 May 2007

K Görür ,
Ö Görüroğlu Öztürk ,
G Polat ,
Y Vayisoğlu ,
D Ü Talas ,
N Güner  and
C Özcan
K Görür*
Affiliation:
Departments of Otorhinolaryngology
Ö Görüroğlu Öztürk
Affiliation:
Biochemistry, Mersin University School of Medicine, Turkey
G Polat
Affiliation:
Biochemistry, Mersin University School of Medicine, Turkey
Y Vayisoğlu
Affiliation:
Departments of Otorhinolaryngology
D Ü Talas
Affiliation:
Departments of Otorhinolaryngology
N Güner
Affiliation:
Departments of Otorhinolaryngology
C Özcan
Affiliation:
Departments of Otorhinolaryngology
*
Address for correspondence: Dr Kemal Görür, Barbaros mah, Marina sit, C Blok, Kat 8, No: 16, Mersin, Turkey. Fax: +90 324 337 43 05 E-mail: [email protected]
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Abstract

Objectives:

Wound healing, epithelial regrowth and collagen synthesis are very important factors in the repair of the traumatised tympanic membrane. The aim of the present study was to determine the role of plasma fibronectine in the aetiopathogenesis of tympanosclerosis.

Methods:

This prospective study included 58 patients with and 49 without tympanosclerosis. No inflammation or trauma was noted in either patient group. All patients underwent otoscopic and otomicroscopic examination, and the degree of tympanosclerosis was graded from mild (stage I) to severe (stage III). Following otological examination, blood samples were taken for plasma fibronectine measurement.

Results:

Following otoscopic and otomicroscopic examinations, patients' tympanosclerosis was graded as follows: 18 patients were stage I; 29 were stage II; and 11 were stage III. Statistical analyses revealed that the plasma fibronectine concentrations were significantly lower in the study group compared with the control group (p = 0.031). In addition, fibronectine levels were lowest in the patients with severest tympanosclerosis (p = 0.0001 in each comparison).

Conclusion:

The results of the present study show that serum fibronectine is important in the development and severity of tympanosclerosis.

Keywords

TympanosclerosisFibronectineTympanic MembraneWound HealingExtracellular Matrix
Type
Main Article
Information
The Journal of Laryngology & Otology , Volume 122 , Issue 4 , April 2008 , pp. 343 - 346
Copyright
Copyright © JLO (1984) Limited 2007

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