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Efficacy of topical application of autologous platelet-rich plasma in adult tonsillectomy patients: a randomised control study

Published online by Cambridge University Press:  14 May 2021

S Nanditha ,
S Gopalakrishnan ,
P Karthikeyan  and
S Singh Bakshi
S Nanditha
Affiliation:
Department of Otorhinolaryngology – Head and Neck Surgery, Mahatma Gandhi Medical College and Research Institute, Sri Balaji Vidyapeeth University, Puducherry, India
S Gopalakrishnan*
Affiliation:
Department of Otorhinolaryngology – Head and Neck Surgery, Mahatma Gandhi Medical College and Research Institute, Sri Balaji Vidyapeeth University, Puducherry, India
P Karthikeyan
Affiliation:
Department of Otorhinolaryngology – Head and Neck Surgery, Mahatma Gandhi Medical College and Research Institute, Sri Balaji Vidyapeeth University, Puducherry, India
S Singh Bakshi
Affiliation:
Department of Otorhinolaryngology – Head and Neck Surgery, All India Institute of medical sciences, Mangalagiri, India
*
Author for correspondence: Dr Gopalakrishnan Surianarayanan, Department of Otorhinolaryngology Head and Neck Surgery, Mahatma Gandhi Medical College and Research Institute, Sri Balaji Vidyapeeth University, Pillayar Kuppam, Puducherry607402, India E-mail: [email protected]
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Abstract

Objective

Tonsillectomy is a painful surgery performed in cases of recurrent tonsillitis. Application of platelet-rich plasma to diminish the pain and morbidity post-tonsillectomy is gaining importance. This study evaluated post-operative pain and morbidity after autologous platelet-rich plasma application on the tonsil beds during tonsillectomy.

Method

Participants were randomised into group 1 (n = 28, peri-operative platelet-rich plasma intervention) and group 2 (n = 28, control). Post-tonsillectomy, patients were assessed (day 0, 1, 2, 3, 7 and 14) for pain, healing and time taken to return to normal activity. Data were analysed by independent t-test and chi-square test with p ≤ 0.05 as the significance level.

Results

A significant decrease in the mean pain score up to day 7 (p < 0.05) and tonsillar fossae healing on days 2 and 3 (p < 0.05) post-tonsillectomy was noted. The majority of the patients returned to their routine activities after a week post-tonsillectomy.

Conclusion

Platelet-rich plasma application was effective in accentuating healing and reducing post-tonsillectomy pain and morbidity.

Keywords

PainPalatine TonsilPlatelet-Rich PlasmaTonsillectomyVisual Analog Scale
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 135 , Issue 6 , June 2021 , pp. 539 - 544
Copyright
Copyright © The Author(s), 2021. Published by Cambridge University Press

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Footnotes

Dr G Surianarayanan takes responsibility for the integrity of the content of the paper

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