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Effect of glucocorticoids on nasal polyposis, with detection of inflammatory response by measurement of nitric oxide levels in nasal polyp tissue

Published online by Cambridge University Press:  15 April 2013

T Bülbül ,
Ö Gümüştekin Bülbül ,
O Güçlü ,
A Serpil Bilsel  and
S Önal Gürsan
T Bülbül
Affiliation:
Department of Otorhinolaryngology, Haydarpaşa Numune Education and Research Hospital, Istanbul, Turkey
Ö Gümüştekin Bülbül
Affiliation:
Department of Biochemistry, School of Medicine, Marmara University, Istanbul, Turkey
O Güçlü*
Affiliation:
Department of Otorhinolaryngology, Çanakkale Onsekiz Mart University Faculty of Medicine, Turkey
A Serpil Bilsel
Affiliation:
Department of Biochemistry, School of Medicine, Marmara University, Istanbul, Turkey
S Önal Gürsan
Affiliation:
Department of Otorhinolaryngology, Haydarpaşa Numune Education and Research Hospital, Istanbul, Turkey
*
Address for correspondence: Assist Prof Dr Oğuz Güçlü, Department of Otorhinolaryngology, Çanakkale Onsekiz Mart University Faculty of Medicine, 17100 Çanakkale, Turkey, Fax: +90 286 2180393 E-mail: [email protected]
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Abstract

Objective:

To investigate endoscopic staging, and nitric oxide levels in the polyp tissue, in patients with nasal polyposis undergoing glucocorticoid therapy.

Methods:

Nasal polyposis was evaluated using endoscopic staging and measurement of polyp tissue nitric oxide levels (chemiluminescence method). Forty-five nasal polyposis patients received either nasal therapy (n = 15), oral therapy (n = 15) or combined therapy (n = 15). Pre-treatment and post-treatment staging and nitric oxide levels were evaluated.

Results:

Endoscopic grading indicated significant post-treatment staging improvements in the oral (p = 0.016) and combined (p = 0.016) groups. Post-treatment staging differed significantly between the three groups (p = 0.041), with greater improvements in the oral and combined groups. All groups showed significantly lower post-treatment nitric oxide levels, compared with baseline, but post-treatment levels did not differ significantly between groups. A significant association was found between treatment response and nitric oxide level alteration.

Conclusion:

This study demonstrates the favourable effects of glucocorticoids on nasal polyposis, and alteration in nitric oxide tissue levels post-treatment. Nitric oxide level in nasal polyp tissue could be an indicator of treatment response, and may aid surgical decision-making by detecting cases that probably will not respond to medical treatment.

Keywords

Nasal PolypsNitric OxideGlucocorticoidsCorticosteroidsChemiluminescence
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 127 , Issue 6 , June 2013 , pp. 584 - 589
Copyright
Copyright © JLO (1984) Limited 2013 

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