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The effect of cetirizine on symptoms and signs of nasal polyposis

Published online by Cambridge University Press:  29 June 2007

Rolf Haye ,
Jens P. Aanesen ,
Bernard Burtin ,
Fergal Donnelly  and
Christian Duby
Rolf Haye*
Affiliation:
Department of Otolaryngology, Rikshospitalet, Oslo, Norway
Jens P. Aanesen
Affiliation:
Department of Otolaryngology, Rikshospitalet, Oslo, Norway
Bernard Burtin
Affiliation:
UCB Pharma, Braine L'Alleud, Belgium
Fergal Donnelly
Affiliation:
UCB Pharma, Braine L'Alleud, Belgium
Christian Duby
Affiliation:
UCB Pharma, Braine L'Alleud, Belgium
*
Address for correspondence: Rolf Haye, M.D., Department of Otolaryngology, Rikshospitalet, 0027 Oslo, Norway. Fax: +47 – 22 86 96 35
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Abstract

Forty-five patients with residual or recurrent nasal polyposis after ethmoidectomy were treated with either cetirizine at twice the daily recommended (20 mg) dose or placebo for three months. The number and size of polyps remained unchanged during the study period. Cetirizine was found to reduce nasal sneezing and rhinorrhoea effectively. The drug also had a beneficial effect on nasal obstruction in the latter part of the study. The side effects of 20 mg (double the recommended daily adult dose) of cetirizine were few and comparable to placebo.

Keywords

Nasal polypsHistamine H1 receptor blockaders
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 112 , Issue 11 , November 1998 , pp. 1042 - 1046
Copyright
Copyright © JLO (1984) Limited 1998

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