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Effect of bidi smoking on nasal mucociliary clearance: a comparative study

Published online by Cambridge University Press:  20 November 2018

B Paul ,
S S Menon ,
R Vasthare ,
R Balakrishnan  and
S Acharya
B Paul
Affiliation:
Department of Public Health Dentistry, Manipal College of Dental Sciences, Manipal, Mahe, India
S S Menon
Affiliation:
Department of Otorhinolaryngology, Kasturba Medical College, Manipal, Mahe, India
R Vasthare
Affiliation:
Department of Public Health Dentistry, Manipal College of Dental Sciences, Manipal, Mahe, India
R Balakrishnan
Affiliation:
Department of Otorhinolaryngology, Kasturba Medical College, Manipal, Mahe, India
S Acharya*
Affiliation:
Department of Public Health Dentistry, Manipal College of Dental Sciences, Manipal, Mahe, India
*
Author for correspondence: Dr Shashidhar Acharya, Department of Public Health Dentistry, Manipal College of Dental Sciences, Manipal Academy of Higher Education(Mahe), Manipal, Karnataka, India576104 E-mail: [email protected] Fax: +91 820 257 1966
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Abstract

Objective

To compare nasal mucociliary clearance in adult non-smokers, cigarette smokers and bidi smokers using the methylene blue dye test.

Methods

The study sample consisted of 20 non-smokers, 20 cigarette smokers and 20 bidi smokers (age range, 20–40 years). A single drop of the methylene blue dye was placed at the anterior end of the inferior turbinate of the participants’ nasal cavity. The distance travelled by the methylene blue in 15 minutes inside the nasal cavity was measured. Nasal mucociliary clearance of the three groups was compared using the Kruskal Wallis test.

Results

Nasal mucociliary clearance was significantly decreased in bidi smokers as compared to cigarette smokers and non-smokers (p < 0.05). Multivariate analysis revealed a significant association between nasal mucociliary clearance and bidi smoking, number of cigarettes or bidis smoked per day, and pack-years (all p < 0.05).

Conclusion

Nasal mucociliary clearance measurement is a simple and useful index for assessing the effect of smoking on the mucociliary activity of nasal mucosa.

Keywords

Mucociliary ClearanceNoseMethylene BlueTobacco
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 132 , Issue 12 , December 2018 , pp. 1077 - 1082
Copyright
Copyright © JLO (1984) Limited, 2018 

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Footnotes

Dr S Acharya takes responsibility for the integrity of the content of the paper

References

1World Health Organization. WHO Report on the Global Tobacco Epidemic: Warning about the Dangers of Tobacco. Geneva: World Health Organization, 2011;50–3Google Scholar
2World Health Organization. WHO Global Report on Trends in Prevalence of Tobacco Smoking. Geneva: World Health Organization, 2015Google Scholar
3Chaudhry, K, Rath, GK. Multisectoral and Intersectoral Approach to National Tobacco Control. Paper commissioned by the World Health Organization on the occasion of the WHO International Conference on Global Tobacco Control Law: ‘Towards a WHO Framework Convention on Tobacco Control’, 7-9 January 2000, New Delhi, IndiaGoogle Scholar
4GATS-2: Global Adult Tobacco Survey. Fact sheet: India 2016-17. In: https://www.mohfw.gov.in/sites/default/files/GATS-2%20FactSheet.pdf [26 October 2018]Google Scholar
5Gupta, PC, Ray, CS, Narake, SS, Palipudi, KM, Sinha, DN, Asma, S et al. Profile of dual tobacco users in India: an analysis from Global Adult Tobacco Survey, 2009-10. Indian J Cancer 2012;49:393–400Google Scholar
6Prabhakar, B, Narake, SS, Pednekar, MS. Social disparities in tobacco use in India: the roles of occupation, education and gender. Indian J Cancer 2012;49:401–9Google Scholar
7Bombick, DW, Bombick, BR, Ayres, PH, Putnam, K, Avalos, J, Borgerding, MF et al. Evaluation of the genotoxic and cytotoxic potential of mainstream whole smoke and smoke condensate from a cigarette containing a novel carbon filter. Fundam Appl Toxicol 1997;39:11–17Google Scholar
8IARC. Tobacco Smoke and Involuntary Smoking, IARC Monographs on the Evaluation of the Carcinogenic Risks of Chemicals to Humans, vol. 83. Lyon: International Agency for Research on Cancer, 2004Google Scholar
9Hecht, SS. Tobacco smoke carcinogens and lung cancer. J Natl Cancer Inst 1999;91:1194–210Google Scholar
10Satir, P, Sleigh, MA. The physiology of cilia and mucociliary interactions. Annu Rev Physiol 1990;52:137–55Google Scholar
11Navarrette, CR, Sisson, JH, Nance, E, Gipson, DA, Hanes, J, Wyatt, TA. Particulate matter in cigarette smoke increases ciliary axoneme beating through mechanical stimulation. J Aerosol Med Pulm Drug Deliv 2012;25:159–68Google Scholar
12Stanley, PJ, Wilson, R, Greenstone, MA, MacWilliam, L, Cole, PJ. Effect of cigarette smoking on nasal mucociliary clearance and ciliary beat frequency. Thorax 1986;41:519–23Google Scholar
13Baby, MK, Muthu, PK, Johnson, P, Kannan, S. Effect of cigarette smoking on nasal mucociliary clearance: a comparative analysis using saccharin test. Lung India 2014;31:39–42Google Scholar
14Ewert, G. On the mucus flow rate in the human nose. Acta Otolaryngol Suppl 1965;200:1–62Google Scholar
15Quinlan, MF, Salman, SD, Swift, DL, Wagner, HN, Proctor, DF. Measurement of mucociliary function in man. Am Rev Respir Dis 1969;99:13–23Google Scholar
16General Assembly of the World Medical Association. World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects. J Am Coll Dent 2014;81:14–18Google Scholar
17Jha, P, Jacob, B, Gajalakshmi, V, Gupta, PC, Dhingra, N, Kumar, R et al. ; RGI-CGHR Investigators. A nationally representative case-control study of smoking and death in India. N Engl J Med 2008;358:1137–47Google Scholar
18Heatherton, TF, Kozlowski, LT, Fagerström, KO. The Fagerström test for nicotine dependence: a revision of the Fagerström Tolerance Questionnaire. Br J Addict 1991;86:1119–27Google Scholar
19Jayant, K, Pakhale, SS. Toxic constituents in bidi smoke. In: LD Sanghwi, LD, Notani P, , eds. Tobacco and Health: The Indian Scene. Bombay: Tata Memorial Centre, 1989;101–10Google Scholar
20Bhonsle, RD, Murti, PR, Gupta, PC. Tobacco habits in India. In: Gupta, PC, Hamner, JE, Murti, PR, eds. Control of Tobacco Related Cancers and Other Diseases. Proceedings of an International Symposium; 1990 Jan 15–19; Bombay, India. Bombay: Oxford University Press, 1992;25–46Google Scholar
21Pakhale, SS, Dolas, SS, Maru, GB. The distribution of total particulate matter (TPM) and nicotine between mainstream and sidestream smoke in bidis and cigarettes. Anal Lett 1997;30:383–94Google Scholar
22Malson, JL, Sims, K, Murty, R, Pickworth, W. Comparison of the nicotine content of tobacco used in bidis and conventional cigarettes. Tob Control 2001;10:181–3Google Scholar
23Abel, EL. Smoking during pregnancy: a review of effects on growth and development of offspring. Hum Biol 1980;52:593–625Google Scholar
24Dempsey, DA, Benowitz, NL. Risks and benefits of nicotine to aid smoking cessation in pregnancy. Drug Saf 2001;24:277–322Google Scholar
25Kim, YH, Kim, YJ, Lee, SE, Kim, YH, Lim, SH, Lee, JH et al. Effect of smoking on bronchial mucus transport velocity under total intravenous anesthesia. Korean J Anesthesiol 2008;55:52–6Google Scholar
26Proenca, M, Xavier, RF, Ramos, D, Cavalheri, V, Pitta, F, Cipulo Ramos, EM. Immediate and short term effects of smoking on nasal mucociliary clearance in smokers [in Portuguese]. Rev Port Pneumol 2011;17:172–6Google Scholar
27Karnitzki, G, Mlynski, G, Mlynski, B. Nasal mucociliary transport time and ciliary beat frequency in healthy probands and patients with sinusitis [in German]. Laryngorhinootologie 1993;72:595–8Google Scholar
28Corbo, GM, Foresi, A, Bonfitto, P, Mugnano, A, Agabiti, A, Cole, PJ. Measurement of nasal mucociliary clearance. Arch Dis Child 1989;64:546–50Google Scholar
29Altuntas, EE, Kaya, A, Uysal, IÖ, Cevit, Ö, Içağasioğlu, D, Müderris, S. Anterior rhinomanometry and determination of nasal mucociliary clearance time with the saccharin test in children with Crimean-Congo hemorrhagic fever. J Craniofac Surg 2013;24:239–42Google Scholar
30Liote, H, Zahm, JM, Pierrot, D, Puchelle, E. Role of mucus and cilia in nasal mucociliary clearance in healthy subjects. Am Rev Respir Dis 1989;140:132–6Google Scholar