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Does smoking increase the risk of peritonsillar abscess formation?

Published online by Cambridge University Press:  02 November 2018

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Abstract

Type
Editorial
Copyright
Copyright © JLO (1984) Limited, 2018 

Although previous retrospective studies have identified a link between smoking and peritonsillar abscess formation, this has not been tested in a prospective study. In this month's issue of The Journal of Laryngology & Otology, Schwarz et al. investigate whether smoking increases the risk of peritonsillar abscess formation.Reference Schwarz, Wolber, Balk and Luers1 The authors of this study identified a statistically significant association between peritonsillar abscess formation and smoking (p = 0.025), in agreement with previous retrospective studies.Reference Klug, Rusan, Clemmensen, Fuursted and Ovesen2 Of the 325 cases of peritonsillar abscess in the National Prospective Quinsy Audit, 17 per cent of patients had a smoking history, although a smoking history was not independently predictive of a 30-day adverse event.3 The authors of this latest study postulate that smoking leads to injury of the oropharyngeal mucosa, thereby increasing the likelihood of developing abscess formation. Smoking may also increase the risk of abscess formation by altering the tonsillar bacterial flora and/or the local and systemic immunological milieu.

Waiting lists for elective surgery are a topical issue in many publicly funded healthcare systems. In order to reduce waiting times for surgery, McLaren et al. introduced a pathway for audiologists to directly schedule children for grommet insertion meeting National Institute for Health and Care Excellence Clinical Guideline 60 (‘CG60').Reference McLaren, Toll, Easto, Willis, Harris and Rainsbury4 Prior to implementation of the new pathway, mean duration between the first audiology appointment and grommet insertion was 294.5 days. Implementation of the new pathway led to a significant reduction in the time interval between the first audiology appointment and surgery (mean duration of 232 days, a reduction of 62.5 days; p = 0.024). The authors stress that the ultimate decision regarding surgery still rests with ENT specialists. In addition, the new pathway places greater responsibility on the audiology team regarding surgery-based treatments. Indeed, this may account for the low number of patients adopting the new pathway. Alternatively, the low numbers being referred directly for grommets by the audiology team may reflect a tighter adherence to National Institute for Health and Care Excellence guidelines by audiologists following a strict protocol. Other ENT departments may choose to adopt such a pathway in order to improve service provision, following consultation with their local audiology departments.

Finally, Noor et al. review the indications for panendoscopy in the investigation of patients with newly diagnosed head and neck squamous cell carcinoma.Reference Noor, Stepan, Kao, Dharmawardana, Ooi and Hodge5 Obtaining a tissue diagnosis was still the most common indication for panendoscopy.Reference Roland, Porter, Fish and Makura6 However, the authors conclude that panendoscopy remains paramount in the assessment of suitability for transoral robotic surgery and in the investigation of an unknown primary.Reference Mackenzie, Watson, Jankowska, Bhide and Simo7 Interestingly, the authors identified only a 1.1 per cent risk of synchronous second primary tumour, of which all were P16 negative, suggesting that the increase in human papillomavirus related disease is responsible for this reduction.Reference Jain, Sikora, Baxi and Morris8, Reference Hamilton, Khan, O'hara and Paleri9

References

1Schwarz, D, Wolber, P, Balk, M, Luers, JC. Analysis of smoking behaviour in patients with peritonsillar abscess: a prospective, matched case–control study. J Laryngol Otol 2018;132:872–4Google Scholar
2Klug, TE, Rusan, M, Clemmensen, KK, Fuursted, K, Ovesen, T. Smoking promotes peritonsillar abscess. Eur Arch Otorhinolaryngol 2013;270:3163–7Google Scholar
3ENT Trainee Research Collaborative – West Midlands. National prospective cohort study of peritonsillar abscess management and outcomes: the Multicentre Audit of Quinsies study. J Laryngol Otol 2016;130:768–76Google Scholar
4McLaren, O, Toll, EC, Easto, R, Willis, E, Harris, S, Rainsbury, J. Streamlining grommet pathways for otitis media with effusion and hearing loss in children: our experience. J Laryngol Otol 2018;132:881–4Google Scholar
5Noor, A, Stepan, L, Kao, SS, Dharmawardana, N, Ooi, EH, Hodge, JC et al. Reviewing indications for panendoscopy in the investigation of head and neck squamous cell carcinoma. J Laryngol Otol 2018;132:901–5Google Scholar
6Roland, N, Porter, G, Fish, B, Makura, Z. Tumour assessment and staging: United Kingdom National Multidisciplinary Guidelines. J Laryngol Otol 2016;130:S53–8Google Scholar
7Mackenzie, K, Watson, M, Jankowska, P, Bhide, S, Simo, R. Investigation and management of the unknown primary with metastatic neck disease: United Kingdom National Multidisciplinary Guidelines. J Laryngol Otol 2016;130:S170–5Google Scholar
8Jain, KS, Sikora, AG, Baxi, SS, Morris, LG. Synchronous cancers in patients with head and neck cancer: risks in the era of human papillomavirus-associated oropharyngeal cancer. Cancer 2013;119:1832–7Google Scholar
9Hamilton, D, Khan, MK, O'hara, J, Paleri, V. The changing landscape of oropharyngeal cancer management. J Laryngol Otol 2017;131:37Google Scholar