Hostname: page-component-586b7cd67f-vdxz6 Total loading time: 0 Render date: 2024-11-26T02:14:13.929Z Has data issue: false hasContentIssue false
  • English
  • Français

Does saliva composition affect the formation of sialolithiasis?

Published online by Cambridge University Press:  15 December 2016

S A Schrøder ,
P Homøe ,
N Wagner  and
A Bardow
S A Schrøder*
Affiliation:
Department of Otorhinolaryngology, Nordsjaellands University Hospital, Hillerod
P Homøe
Affiliation:
Department of Otorhinolaryngology and Maxillofacial Surgery, Zealand University Hospital, Koege
N Wagner
Affiliation:
Department of Otorhinolaryngology, Aleris-Hamlet Hospital, Ringsted
A Bardow
Affiliation:
Department of Oral Medicine, Dental School of Copenhagen, University of Copenhagen, Denmark
*
Address for correspondence: Dr Stine A Schrøder, Department of Otorhinolaryngology, Nordsjaellands University Hospital, Hillerod, Denmark Fax: +45 4829 3811 E-mail: [email protected]
Get access Rights & Permissions [Opens in a new window]

Abstract

Objective:

Saliva composition may affect sialolithiasis formation; thus, this study compared the salivary inorganic composition of sialolithiasis patients with that of healthy controls, and determined whether salivary inorganic composition changes after sialolithiasis surgery.

Methods:

The study included 40 patients with sialolithiasis and 40 matched healthy controls. Patients were examined before and after sialolithiasis surgery; controls were examined once. Flow rate and the inorganic saliva composition in unstimulated whole saliva were assessed.

Results:

Patients’ salivary flow prior to surgery was significantly lower compared to that of healthy controls, but equalised after surgery. Prior to surgery, patients’ saliva exhibited higher concentrations of calcium, magnesium, phosphorous compared to that of healthy controls. The concentration of most ions remained high after sialolithiasis surgery.

Conclusion:

Sialolithiasis patients had increased salivary concentrations of the ions that constitute the main inorganic phase of most sialoliths, and this may confer a risk for developing sialolithiasis.

Keywords

Salivary Gland CalculiCalculiHumansOral HealthCalciumMagnesiumPhosphates
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 131 , Issue 2 , February 2017 , pp. 162 - 167
Copyright
Copyright © JLO (1984) Limited 2016 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1 Sherman, JA, McGurk, M. Lack of correlation between water hardness and salivary calculi in England. Br J Oral Maxillofac Surg 2000;38:50–3CrossRefGoogle ScholarPubMed
2 Escudier, MP, McGurk, M. Symptomatic sialoadenitis and sialolithiasis in the English population, an estimate of the cost of hospital treatment. Br Dent J 1999;186:463–6CrossRefGoogle ScholarPubMed
3 Delli, K, Spijkervet, FK, Vissink, A. Salivary gland diseases: infections, sialolithiasis and mucoceles. Monogr Oral Sci 2014;24:135–48CrossRefGoogle ScholarPubMed
4 Schroder, S, Homoe, P, Wagner, N, Vataire, AL, Lundager Madsen, HE, Bardow, A. Does drinking water influence hospital-admitted sialolithiasis on an epidemiological level in Denmark? BMJ Open 2015;5:e007385 CrossRefGoogle Scholar
5 Zenk, J, Constantinidis, J, Kydles, S, Hornung, J, Iro, H. Clinical and diagnostic findings of sialolithiasis [in German]. HNO 1999;47:963–9CrossRefGoogle ScholarPubMed
6 Sigismund, PE, Zenk, J, Koch, M, Schapher, M, Rudes, M, Iro, H. Nearly 3,000 salivary stones: some clinical and epidemiologic aspects. Laryngoscope 2015;125:1879–82CrossRefGoogle Scholar
7 Lustmann, J, Regev, E, Melamed, Y. Sialolithiasis. A survey on 245 patients and a review of the literature. Int J Oral Maxillofac Surg 1990;19:135–8CrossRefGoogle Scholar
8 Wilson, KF, Meier, JD, Ward, PD. Salivary gland disorders. Am Fam Physician 2014;89:882–8Google ScholarPubMed
9 Witt, RL, Iro, H, Koch, M, McGurk, M, Nahlieli, O, Zenk, J. Minimally invasive options for salivary calculi. Laryngoscope 2012;122:1306–11CrossRefGoogle ScholarPubMed
10 Harrison, JD. Causes, natural history, and incidence of salivary stones and obstructions. Otolaryngol Clin North Am 2009;42:927–47CrossRefGoogle ScholarPubMed
11 Marchal, F, Kurt, AM, Dulguerov, P, Lehmann, W. Retrograde theory in sialolithiasis formation. Arch Otolaryngol Head Neck Surg 2001;127:66–8CrossRefGoogle ScholarPubMed
12 Huoh, KC, Eisele, DW. Etiologic factors in sialolithiasis. Otolaryngol Head Neck Surg 2011;145:935–9CrossRefGoogle ScholarPubMed
13 Kraaij, S, Karagozoglu, KH, Kenter, YA, Pijpe, J, Gilijamse, M, Brand, HS. Systemic diseases and the risk of developing salivary stones: a case control study. Oral Surg Oral Med Oral Pathol Oral Radiol 2015;119:539–43CrossRefGoogle ScholarPubMed
14 Yiu, AJ, Kalejaiye, A, Amdur, RL, Todd Hesham, HN, Bandyopadhyay, BC. Association of serum electrolytes and smoking with salivary gland stone formation. Int J Oral Maxillofac Surg 2016;45:764–8CrossRefGoogle ScholarPubMed
15 Triantafyllou, A, Harrison, JD, Garrett, JR. Production of salivary microlithiasis in cats by parasympathectomy: light and electron microscopy. Int J Exp Pathol 1993;74:103–12Google ScholarPubMed
16 Carter, LC. Lumps and bumps–what is that stone? Alpha Omegan 2010;103:151–6CrossRefGoogle ScholarPubMed
17 Blatt, IM. Studies in sialolithiasis. III. Pathogenesis, diagnosis and treatment. South Med J 1964;57:723–9CrossRefGoogle ScholarPubMed
18 Grases, F, Santiago, C, Simonet, BM, Costa-Bauza, A. Sialolithiasis: mechanism of calculi formation and etiologic factors. Clin Chim Acta 2003;334:131–6CrossRefGoogle ScholarPubMed
19 Nolasco, P, Anjos, AJ, Marques, JM, Cabrita, F, da Costa, EC, Mauricio, A et al. Structure and growth of sialoliths: computed microtomography and electron microscopy investigation of 30 specimens. Microsc Microanal 2013;19:1190–203CrossRefGoogle ScholarPubMed
20 Rakesh, N, Bhoomareddy Kantharaj, YD, Agarwal, M, Agarwal, K. Ultrastructural and elemental analysis of sialoliths and their comparison with nephroliths. J Investig Clin Dent 2014;5:32–7CrossRefGoogle ScholarPubMed
21 Mimura, M, Tanaka, N, Ichinose, S, Kimijima, Y, Amagasa, T. Possible etiology of calculi formation in salivary glands: biophysical analysis of calculus. Med Mol Morphol 2005;38:189–95CrossRefGoogle ScholarPubMed
22 Teymoortash, A, Buck, P, Jepsen, H, Werner, JA. Sialolith crystals localized intraglandularly and in the Wharton's duct of the human submandibular gland: an X-ray diffraction analysis. Arch Oral Biol 2003;48:233–6CrossRefGoogle ScholarPubMed
23 Gopal, R, Calvo, C, Ito, J, Sabine, WK. Crystal structure of synthetic Mg-whitlockite, Ca18Mg2H2(PO4)14. Can J Chem 1974;52:1155–64CrossRefGoogle Scholar
24 Su, YX, Zhang, K, Ke, ZF, Zheng, GS, Chu, M, Liao, GQ. Increased calcium and decreased magnesium and citrate concentrations of submandibular/sublingual saliva in sialolithiasis. Arch Oral Biol 2010;55:15–20 CrossRefGoogle ScholarPubMed
25 Navazesh, M, Kumar, SK. Measuring salivary flow: challenges and opportunities. J Am Dent Assoc 2008;139(suppl):35S–40S CrossRefGoogle ScholarPubMed
26 Fried, R, Hoeflmayr, J, Velosy, G. A new, highly sensitive method for the determination of chloride in body fluids without protein precipitation [in German]. Z Klin Chem Klin Biochem 1972;10:280 Google ScholarPubMed
27 Bardow, A, Lykkeaa, J, Qvist, V, Ekstrand, K, Twetman, S, Fiehn, NE. Saliva composition in three selected groups with normal stimulated salivary flow rates, but yet major differences in caries experience and dental erosion. Acta Odontol Scand 2014;72:466–73CrossRefGoogle ScholarPubMed
28 Lustmann, J, Shteyer, A. Salivary calculi: ultrastructural morphology and bacterial etiology. J Dent Res 1981;60:1386–95CrossRefGoogle ScholarPubMed
29 Harrison, JD, Triantafyllou, A, Baldwin, D, Garrett, JR, Schafer, H. Histochemical and biochemical determination of calcium in salivary glands of cat. Histochemistry 1993;100:155–9CrossRefGoogle ScholarPubMed
30 Bardow, A, Moe, D, Nyvad, B, Nauntofte, B. The buffer capacity and buffer systems of human whole saliva measured without loss of CO2. Arch Oral Biol 2000;45:1–12 CrossRefGoogle ScholarPubMed