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The diagnosis and surgical management of olfactory neuroblastoma: The role of craniofacial resection

Published online by Cambridge University Press:  29 June 2007

P. Chapman ,
R. L. Carter  and
P. Clifford
P. Chapman*
Affiliation:
Head and Neck Unit and Department of Pathology, Royal Marsden Hospital and Institute of Cancer Research, London and Sutton.
R. L. Carter
Affiliation:
Head and Neck Unit and Department of Pathology, Royal Marsden Hospital and Institute of Cancer Research, London and Sutton.
P. Clifford
Affiliation:
Head and Neck Unit and Department of Pathology, Royal Marsden Hospital and Institute of Cancer Research, London and Sutton.
*
ENT Department, St. Mary's Hospital, Praed Street, Paddington, W2.
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Summary

The diagnosis and clinical management of olfactory neuroblastoma are discussed. Computerized tomography is a valuable means of assessing the pre-operative extent of disease and the efficacy of subsequent major surgery. The tissue diagnosis is facilitated by electron microscopy, demonstrating the presence of dence core vesicles and cytoplasmic filaments. Radiotherapy followed by craniofacial resection is the treatment of choice for olfactory neuroblastomas that are locally extensive at presentation.

Type
Research Article
Information
The Journal of Laryngology & Otology , Volume 95 , Issue 8 , August 1981 , pp. 785 - 799
Copyright
Copyright © JLO (1984) Limited 1981

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