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Decreased mortality in coronavirus disease 2019 associated mucormycosis with aspirin use: a retrospective cohort study

Published online by Cambridge University Press:  14 June 2022

Z Shaikh Open the ORCID record for Z Shaikh [Opens in a new window] ,
S Sarkar ,
R Biswas ,
A Adhikari ,
V K Hallur ,
P K Parida ,
C Preetam ,
P Pradhan ,
D K Samal  and
A Nayak
...Show all authors
Z Shaikh
Affiliation:
Department of ENT and Head and Neck Surgery, All India Institute of Medical Sciences, Bhubaneswar, India
S Sarkar*
Affiliation:
Department of ENT and Head and Neck Surgery, All India Institute of Medical Sciences, Bhubaneswar, India
R Biswas
Affiliation:
Department of Community and Family Medicine, All India Institute of Medical Sciences, Bhubaneswar, India
A Adhikari
Affiliation:
Department of ENT and Head and Neck Surgery, All India Institute of Medical Sciences, Bhubaneswar, India
V K Hallur
Affiliation:
Department of Microbiology, All India Institute of Medical Sciences, Bhubaneswar, India
P K Parida
Affiliation:
Department of ENT and Head and Neck Surgery, All India Institute of Medical Sciences, Bhubaneswar, India
C Preetam
Affiliation:
Department of ENT and Head and Neck Surgery, All India Institute of Medical Sciences, Bhubaneswar, India
P Pradhan
Affiliation:
Department of ENT and Head and Neck Surgery, All India Institute of Medical Sciences, Bhubaneswar, India
D K Samal
Affiliation:
Department of ENT and Head and Neck Surgery, All India Institute of Medical Sciences, Bhubaneswar, India
A Nayak
Affiliation:
Department of ENT and Head and Neck Surgery, All India Institute of Medical Sciences, Bhubaneswar, India
S Chadaram
Affiliation:
Department of ENT and Head and Neck Surgery, All India Institute of Medical Sciences, Bhubaneswar, India
K K Das
Affiliation:
Department of ENT and Head and Neck Surgery, All India Institute of Medical Sciences, Bhubaneswar, India
S Chakraborty
Affiliation:
Department of ENT and Head and Neck Surgery, All India Institute of Medical Sciences, Bhubaneswar, India
P Sharma
Affiliation:
Department of ENT and Head and Neck Surgery, All India Institute of Medical Sciences, Bhubaneswar, India
A K Veeti
Affiliation:
Department of ENT and Head and Neck Surgery, All India Institute of Medical Sciences, Bhubaneswar, India
V Karakkandy
Affiliation:
Department of ENT and Head and Neck Surgery, All India Institute of Medical Sciences, Bhubaneswar, India
A Mishra
Affiliation:
Department of ENT and Head and Neck Surgery, All India Institute of Medical Sciences, Bhubaneswar, India
Y Mittal
Affiliation:
Department of ENT and Head and Neck Surgery, All India Institute of Medical Sciences, Bhubaneswar, India
K S Chithambaram
Affiliation:
Department of ENT and Head and Neck Surgery, All India Institute of Medical Sciences, Bhubaneswar, India
A Swarup
Affiliation:
Department of ENT and Head and Neck Surgery, All India Institute of Medical Sciences, Bhubaneswar, India
S Chenniappan
Affiliation:
Department of ENT and Head and Neck Surgery, All India Institute of Medical Sciences, Bhubaneswar, India
A Shah
Affiliation:
Department of ENT and Head and Neck Surgery, All India Institute of Medical Sciences, Bhubaneswar, India
*
Author for correspondence: Dr S Sarkar, Department of ENT and Head and Neck Surgery, All India Institute of Medical Sciences, Bhubaneswar751019, India E-mail: [email protected]
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Abstract

Objective

Rhino-orbito-cerebral mucormycosis is a rapidly progressive disease with high mortality rates of about 60 per cent. The increasing incidence of rhino-orbito-cerebral mucormycosis in coronavirus disease 2019 patients in India and worldwide has become a matter of concern owing to the case fatality rate. This study explored the use of low dose aspirin in decreasing the mortality rate of coronavirus disease 2019 associated mucormycosis.

Method

This was a retrospective observational study. Patients suffering from post-coronavirus disease 2019 mucormycosis were included in the study. Each patient was treated with surgical debridement and systemic amphotericin B. Low dose aspirin was added, and mortality rates were compared with the patients who did not receive aspirin.

Results

The demographic data and rhino-orbito-cerebral mucormycosis staging between the two groups were not significantly different. There was a statistically significant difference in mortality outcomes between the two groups (p = 0.029) and a 1.77 times higher risk of dying for patients not receiving aspirin. Kaplan–Meier survival indicated that patients receiving aspirin had better survival rates (p = 0.04).

Conclusion

Low dose aspirin improves survival rates in coronavirus disease 2019 associated mucormycosis.

Keywords

COVID-19 Associated MucormycosisAspirinMortality
Type
Main Article
Information
The Journal of Laryngology & Otology , Volume 136 , Issue 12 , December 2022 , pp. 1309 - 1313
Copyright
Copyright © The Author(s), 2022. Published by Cambridge University Press on behalf of J.L.O. (1984) LIMITED

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Footnotes

Dr S Sarkar takes responsibility for the integrity of the content of the paper

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