Hostname: page-component-cd9895bd7-gvvz8 Total loading time: 0 Render date: 2024-12-23T20:25:05.535Z Has data issue: false hasContentIssue false
  • English
  • Français

Cyclooxygenase-2 expression in Warthin's tumour

Published online by Cambridge University Press:  08 March 2006

A H C Loy ,
T C Putti  and
L K S Tan
A H C Loy
Affiliation:
Department of Pathology, National University Hospital, Singapore
T C Putti
Affiliation:
Department of Otorhinolaryngology, Tan Tock Seng Hospital, Singapore
L K S Tan
Affiliation:
Department of Otolaryngology-Head and Neck Surgery, National University Hospital, Singapore
Get access Rights & Permissions [Opens in a new window]

Abstract

Objectives: To determine whether cyclooxygenase-2 (COX-2) is overexpressed in Warthin's tumours, and to characterize its pattern of expression.

Methods: Twenty-one paraffin-embedded Warthin's tumour specimens were analysed by immunohistochemical staining for expression of human COX-2. Semi-quantitative analysis of the staining was performed.

Results: In all of the specimens, we found that there was overexpression of COX-2 within the epithelial component of the tumours, with no expression in the lymphoid components. There was also overexpression of COX-2 in the salivary duct system of normal parotid tissue.

Conclusions: Our results suggest that COX-2 is up-regulated in the epithelial component of Warthin's tumours. Our findings support the hypothesis that Warthin's tumours originate from heterotopic ductal epithelial cells of the parotid gland. The role of COX-2 expression in the pathogenesis of Warthin's tumours remains to be determined.

Keywords

Cyclooxygenase-2ImmunohistochemistryWarthin’s Tumour
Type
Research Article
Information
The Journal of Laryngology & Otology , Volume 119 , Issue 7 , July 2005 , pp. 515 - 518
Copyright
© 2005 Royal Society of Medicine Press

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)