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Comparison of the Adult Comorbidity Evaluation 27 and the Charlson Comorbidity indices in patients with laryngeal squamous cell carcinoma

Published online by Cambridge University Press:  28 March 2012

V S Nesic ,
Z M Petrovic ,
S B Sipetic ,
S D Jesic ,
I A Soldatovic  and
D A Kastratovic
V S Nesic*
Affiliation:
School of Medicine, University of Belgrade, Serbia Clinic of Otorhinolaryngology and Maxillofacial Surgery, School of Medicine, University of Belgrade, Serbia
Z M Petrovic
Affiliation:
School of Medicine, University of Belgrade, Serbia Clinic of Otorhinolaryngology and Maxillofacial Surgery, School of Medicine, University of Belgrade, Serbia
S B Sipetic
Affiliation:
Institute of Epidemiology, School of Medicine, University of Belgrade, Serbia
S D Jesic
Affiliation:
School of Medicine, University of Belgrade, Serbia Clinic of Otorhinolaryngology and Maxillofacial Surgery, School of Medicine, University of Belgrade, Serbia
I A Soldatovic
Affiliation:
Institute of Medical Statistics and Informatics, School of Medicine, University of Belgrade, Serbia
D A Kastratovic
Affiliation:
Department of Clinical Pharmacology, Clinical Centre of Serbia, Belgrade, Serbia
*
Address for correspondence: Dr Vladimir S Nesic, Clinic of Otorhinolaryngology and Maxillofacial Surgery, Clinical Centre of Serbia, Pasterova 2, 11000 Belgrade, Serbia Fax: +381 112418217 E-mail: [email protected]
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Abstract

Objective:

This study aimed to compare the prognostic impact of comorbidity grading by the Adult Comorbidity Evaluation 27 index and the Charlson Comorbidity Index on the five-year overall and disease-specific survival in patients undergoing surgery for laryngeal squamous cell carcinoma.

Methods:

The impact of comorbidity and other factors on survival was examined retrospectively in a group of 177 patients with previously untreated tumour stage one to four laryngeal squamous cell carcinoma surgically treated at the Clinic of Otorhinolaryngology and Maxillofacial Surgery, Clinical Centre of Serbia, between 2000 and 2003. The Cox proportional hazard model was used to identify independent prognostic factors.

Results:

On univariate analysis, comorbidity had an impact on prognosis regardless of which index was used. On multivariate analysis, the significant predictors of patients' five-year overall and disease-specific survival were tumour–node–metastasis stage and comorbidity as graded by the Adult Comorbidity Evaluation 27 index.

Conclusion:

The Adult Comorbidity Evaluation 27 index is a more reliable predictor of survival than the Charlson Comorbidity Index in patients with laryngeal squamous cell carcinoma.

Keywords

Laryngeal NeoplasmsSquamous Cell CarcinomaComorbiditySurvival Analysis
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 126 , Issue 5 , May 2012 , pp. 516 - 524
Copyright
Copyright © JLO (1984) Limited 2012

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References

1Kaplan, MH, Feinstein, AR. The importance of classifying initial co-morbidity in evaluating the outcome of diabetes mellitus. J Chronic Dis 1974;27:387–404CrossRefGoogle ScholarPubMed
2Charlson, ME, Pompei, P, Ales, KL, MacKenzie, CR. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis 1987;40:373–83CrossRefGoogle ScholarPubMed
3Piccirillo, JF, Wells, CK, Sasaki, CT, Feinstein, AR. New clinical severity staging system for cancer of the larynx. Ann Otol Rhinol Laryngol 1994;103:83–92CrossRefGoogle ScholarPubMed
4Linn, BS, Linn, MW, Lee, G. Cumulative illness rating scale. J Am Geriatr Soc 1968;5:622–6CrossRefGoogle Scholar
5Greenfield, S, Apolone, G, McNeil, BJ, Cleary, PD. The importance of co-existent disease in the occurrence of postoperative complications and one-year recovery in patients undergoing total hip replacement. Comorbidity and outcomes after hip replacement. Med Care 1993;31:141–54CrossRefGoogle ScholarPubMed
6Klabunde, CN, Potosky, AL, Legler, JM, Warren, JL. Development of a comorbidity index using physician claims data. J Clin Epidemiol 2000;53:1258–67CrossRefGoogle ScholarPubMed
7Piccirillo, JF, Creech, CM, Zequeira, R, Anderson, S, Johnston, AS. Inclusion of comorbidity into oncology data registries. Journal of Registry Management 1999;26:66–70Google Scholar
8Piccirillo, JF. Importance of comorbidity in head and neck cancer. Laryngoscope 2000;110:593–602CrossRefGoogle ScholarPubMed
9Paleri, V, Wight, RG, Davies, GR. Impact of comorbidity on the outcome of laryngeal squamous cancer. Head Neck 2003;25:1019–26CrossRefGoogle ScholarPubMed
10Castro, MA, Dedivitis, RA, Ribeiro, KC. Comorbidity measurement in patients with laryngeal squamous cell carcinoma. ORL J Otorhinolaryngol Relat Spec 2007;69:146–52CrossRefGoogle ScholarPubMed
11Chen, AY, Matson, LK, Roberts, D, Goepfert, H. The significance of comorbidity in advanced laryngeal cancer. Head Neck 2001;23:566–72CrossRefGoogle ScholarPubMed
12Piccirillo, JF, Lacy, PD, Basu, A, Spitznagel, EL. Development of a new head and neck cancer-specific comorbidity index. Arch Otolaryngol Head Neck Surg 2002;128:1172–9CrossRefGoogle ScholarPubMed
13Cleves, MA, Sanchez, N, Draheim, M. Evaluation of two competing methods for calculating Charlson's comorbidity index when analyzing short-term mortality using administrative data. J Clin Epidemiol 1997;50:903–8CrossRefGoogle ScholarPubMed
14Sabin, SL, Rosefeld, RM, Sundaram, K, Har-El, G, Lucente, FE. The impact of comorbidity and age on survival with laryngeal cancer. Ear Nose Throat J 1999;78:578, 581–4CrossRefGoogle ScholarPubMed
15Head and Neck. In: Edge, SB, Byrd, DR, Compton, CC, Fritz, AG, Greene, FL, Trotti, A, eds. AJCC Cancer Staging Manual, 7th edn.New York: Springer, 2010;57–68Google ScholarPubMed
16Datema, FR, Ferrier, MB, van der Schroeff, MP, Baatenburg de Jong, RJ. Impact of comorbidity on short-term mortality and overall survival of head and neck cancer patients. Head Neck 2010;32:728–36CrossRefGoogle ScholarPubMed
17Paleri, V, Narayan, R, Wight, RG. Descriptive study of the type and severity of decompensation caused by comorbidity in a population of patients with laryngeal squamous cancer. J Laryngol Otol 2004;118:517–21CrossRefGoogle Scholar
18Singh, B, Bhaya, M, Zimbler, M, Stern, J, Roland, JT, Rosenfeld, RM et al. Impact of comorbidity on outcome of young patients with head and neck squamous cell carcinoma. Head Neck 1998;20:1–73.0.CO;2-8>CrossRefGoogle ScholarPubMed
19Singh, B, Bhaya, M, Stern, J, Roland, JT, Zimbler, M, Rosenfeld, RM et al. Validation of the Charlson comorbidity index in patients with head and neck cancer: a multi-institutional study. Laryngoscope 1997;107:1469–75CrossRefGoogle ScholarPubMed
20Paleri, V, Wight, RG. Applicability of the Adult Comorbidity Evaluation - 27 and the Charlson indexes to assess comorbidity by notes extraction in a cohort of United Kingdom patients with head and neck cancer: a retrospective study. J Laryngol Otol 2002;116:200–5CrossRefGoogle Scholar
21Hall, SF, Rochon, PA, Streiner, DL, Paszat, LF, Groome, PA, Rohland, SL. Measuring comorbidity in patients with head and neck cancer. Laryngoscope 2002;112:1988–96CrossRefGoogle ScholarPubMed
22Piccirillo, JF, Spitznagel, EL Jr, Vermani, N, Costas, I, Schnitzler, M. Comparison of comorbidity indices for patients with head and neck cancer. Med Care 2004;42:482–6CrossRefGoogle ScholarPubMed
23Montero, EH, Trufero, JM, Romeo, JA, Terré, FC. Comorbidity and prognosis in advanced hypopharyngeal-laryngeal cancer under combined therapy. Tumori 2008;94:24–9CrossRefGoogle ScholarPubMed
24Cascorbi, I. The promises of personalized medicine. Eur J Clin Pharmacol 2010;66:749–54CrossRefGoogle ScholarPubMed
25Paleri, V, Wight, RG. A cross-comparison of retrospective notes extraction and combined notes extraction and patient interview in the completion of a comorbidity index (ACE-27) in a cohort of United Kingdom patients with head and neck cancer. J Laryngol Otol 2002;116:937–41CrossRefGoogle Scholar