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Comparison of the Adult Comorbidity Evaluation 27 and the Charlson Comorbidity indices in patients with laryngeal squamous cell carcinoma

Published online by Cambridge University Press:  28 March 2012

V S Nesic ,
Z M Petrovic ,
S B Sipetic ,
S D Jesic ,
I A Soldatovic  and
D A Kastratovic
V S Nesic*
Affiliation:
School of Medicine, University of Belgrade, Serbia Clinic of Otorhinolaryngology and Maxillofacial Surgery, School of Medicine, University of Belgrade, Serbia
Z M Petrovic
Affiliation:
School of Medicine, University of Belgrade, Serbia Clinic of Otorhinolaryngology and Maxillofacial Surgery, School of Medicine, University of Belgrade, Serbia
S B Sipetic
Affiliation:
Institute of Epidemiology, School of Medicine, University of Belgrade, Serbia
S D Jesic
Affiliation:
School of Medicine, University of Belgrade, Serbia Clinic of Otorhinolaryngology and Maxillofacial Surgery, School of Medicine, University of Belgrade, Serbia
I A Soldatovic
Affiliation:
Institute of Medical Statistics and Informatics, School of Medicine, University of Belgrade, Serbia
D A Kastratovic
Affiliation:
Department of Clinical Pharmacology, Clinical Centre of Serbia, Belgrade, Serbia
*
Address for correspondence: Dr Vladimir S Nesic, Clinic of Otorhinolaryngology and Maxillofacial Surgery, Clinical Centre of Serbia, Pasterova 2, 11000 Belgrade, Serbia Fax: +381 112418217 E-mail: [email protected]
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Abstract

Objective:

This study aimed to compare the prognostic impact of comorbidity grading by the Adult Comorbidity Evaluation 27 index and the Charlson Comorbidity Index on the five-year overall and disease-specific survival in patients undergoing surgery for laryngeal squamous cell carcinoma.

Methods:

The impact of comorbidity and other factors on survival was examined retrospectively in a group of 177 patients with previously untreated tumour stage one to four laryngeal squamous cell carcinoma surgically treated at the Clinic of Otorhinolaryngology and Maxillofacial Surgery, Clinical Centre of Serbia, between 2000 and 2003. The Cox proportional hazard model was used to identify independent prognostic factors.

Results:

On univariate analysis, comorbidity had an impact on prognosis regardless of which index was used. On multivariate analysis, the significant predictors of patients' five-year overall and disease-specific survival were tumour–node–metastasis stage and comorbidity as graded by the Adult Comorbidity Evaluation 27 index.

Conclusion:

The Adult Comorbidity Evaluation 27 index is a more reliable predictor of survival than the Charlson Comorbidity Index in patients with laryngeal squamous cell carcinoma.

Keywords

Laryngeal NeoplasmsSquamous Cell CarcinomaComorbiditySurvival Analysis
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 126 , Issue 5 , May 2012 , pp. 516 - 524
Copyright
Copyright © JLO (1984) Limited 2012

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