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A comparison of artificial saliva and pilocarpine in radiation induced xerostomia

Published online by Cambridge University Press:  29 June 2007

A. N. Davies  and
J. Singer
A. N. Davies*
Affiliation:
South East London Radiotherapy Department, St Thomas' Hospital, London
J. Singer
Affiliation:
South East London Radiotherapy Department, St Thomas' Hospital, London
*
Dr A.N.Davies, GP Trainee, Cranleigh Health Centre, Cranleigh, Surrey GU6 8AE.
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Abstract

Twenty patients with radiation-induced xerostomia were entered into a prospective randomized crossover study comparing a mucin-based artificial saliva (Saliva Orthana) and a mouthwash containing pilocarpine 5 mg three times a day. Overall the patients found that the pilocarpine mouthwash was more effective than the artificial saliva in relieving their symptoms (p = 0.04), and 47 per cent of the patients wanted to continue with this treatment after the study had finished.

Keywords

XerostomiaRadiotherapyPilocarpineSaliva, artificial
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 108 , Issue 8 , August 1994 , pp. 663 - 665
Copyright
Copyright © JLO (1984) Limited 1994

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References

Ferguson, M. M., Hayes, P., Highton, J., Jones, D. S., MacFadyen, E. E., Palmer, D. G. (1991) Pilocarpine oral solution (letter to editor). British Dental Journal 170 (7): 251.CrossRefGoogle Scholar
Ferguson, M. M. (1993) Pilocarpine and other cholinergic drugs in the management of salivary gland dysfunction. Oral Surgery, Oral Medicine, Oral Pathology 75: 186–191.CrossRefGoogle ScholarPubMed
Fox, P. C, van der Ven, P. E, Baum, B. J., Mandel, I. D. (1986) Pilocarpine for the treatment of xerostomia associated with salivary gland dysfunction. Oral Surgery, Oral Medicine, Oral Pathology 61: 243–245.CrossRefGoogle ScholarPubMed
Fox, P. C, Atkinson, J. C, Macynski, A. A., Wolff, A., Kung, D. S., Valdez, I. H., Jackson, W., Delapenha, R. A., Shiroky, J., Baum, B. J. (1991) Pilocarpine treatment of salivary gland hypofunction and dry mouth (xerostomia). Archives of Internal Medicine 151: 1149–1152.CrossRefGoogle ScholarPubMed
Greenspan, D., Daniels, T. E. (1987) Effectiveness of pilocarpine in post-radiation xerostomia. Cancer 59: 1123–1125.3.0.CO;2-X>CrossRefGoogle Scholar
Greenspan, D. (1990) Management of salivary dysfunction. National Cancer Institute Monographs 9: 159–161.Google Scholar
Joensuu, H., Bostrom, P., Makkonen, T. (1993) Pilocarpine and carbacoline in treatment of radiation-induced xerostomia. Radiotherapy Oncology 26: 33–37.CrossRefGoogle ScholarPubMed
Johnson, J. T., Flerretti, G. A., Nethery, W. J., Valdez, I. H., Fox, P. C, Ng, D., Muscoplat, C. C, Gallagher, S. C. (1993) Oral pilocarpine for post-irradiation xerostomia in patients with head and neck cancer. New England Journal of Medicine 329: 390–395.CrossRefGoogle ScholarPubMed
Le Veque, F. G., Montgomery, M., Potter, D., Zimmer, M. B., Rieke, J. W., Steiger, B. W., Gallagher, S. C, Muscoplat, C. C. (1993) A multicenter, randomized double blind placebo controlled, dose titration study of oral pilocarpine for treatment of radiation induced xerostomia in head and neck cancer patients. Journal of Clinical Oncology 11: 1124–1131.CrossRefGoogle ScholarPubMed
S'Gravenmade, E. J., Roukema, P. A., Panders, A. K. (1974) The effect of mucin-containing artificial saliva on severe xerostomia. International Journal of Oral Surgery 3: 435–439.CrossRefGoogle ScholarPubMed
Visch, L. L., S'Gravenmade, E. J., Schaub, R. M. H., van Putten, W. L. J., Vissink, A. (1986) A double blind crossover trial of CMCand mucin-containing saliva substitutes. International Journal of Oral Maxillofacial Surgery 15: 395–400.CrossRefGoogle Scholar