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Cefotaxime prophylaxis in major non-contaminated head and neck surgery: one-day vs. seven-day therapy

Published online by Cambridge University Press:  29 June 2007

Erkan Mustafa  and
Aslan Tahsin
Erkan Mustafa*
Affiliation:
Department of Otolaryngology, University of Erciyes School of Medicine, Kayseri, Türkiye.
Aslan Tahsin
Affiliation:
Department of Otolaryngology, University of Erciyes School of Medicine, Kayseri, Türkiye.
*
Assistant Professor Dr Mustafa Erkan, PK 312, 38002 Kayseri, Tiirkiye.
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Abstract

Patients who undergo major surgery of head and neck benefit from perioperative antibiotic prophylaxis. This study was developed to determine if seven days of antibiotic administration would be more effective than one day. A prospective randomized double blind study was designed. Patients were randomly assigned to receive cefotaxime sodium for either 24 hours or seven days. In each case, the drug was administered intramuscularly, beginning one to two hours pre-operatively and continued for the prescribed period. Sixty patients were included in the trial. Of 30 patients assigned to one day of perioperative prophylaxis, wound infection developed in four (13 per cent). Of 30 patients assigned to seven days of perioperative antibiotic prophylaxis, wound infection developed in three (10 per cent) (P>0.05). These data suggest that no beneficial effect from administration of antibiotics for longer than 24 hours post-operatively can be achieved in patients who undergo major head and neck surgery.

Keywords

AntibioticsSurgeryhead and neck
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 107 , Issue 1 , January 1993 , pp. 30 - 32
Copyright
Copyright © JLO (1984) Limited 1993

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