Hostname: page-component-78c5997874-s2hrs Total loading time: 0 Render date: 2024-11-20T00:00:11.407Z Has data issue: false hasContentIssue false
  • English
  • Français

Carcinoma of the ear: a case report of a possible association with chlorinated disinfectants

Published online by Cambridge University Press:  29 June 2007

S. A. Monem ,
D. A. Moffat  and
M. C. Frampton
S. A. Monem*
Affiliation:
Department of Neuro-otology and Skull Base Surgery, Addenbrooke's Hospital, Cambridge.
D. A. Moffat
Affiliation:
Department of Neuro-otology and Skull Base Surgery, Addenbrooke's Hospital, Cambridge.
M. C. Frampton
Affiliation:
Department of Otolaryngology/Head and Neck Surgery, Bedford Hospital, Bedford, UK.
*
Address for correspondence: Mr S. A. Monem, Department of Neuro-otology/Skull Base Surgery, Addenbrookes Hospital (Box 48), Hills Road, Cambridge CB2 2QQ. Fax: +44 (0)1223 217559
Get access Rights & Permissions [Opens in a new window]

Abstract

In this report we present a case of squamous cell carcinoma developing in a mastoid cavity after prolonged exposure to the chemical disinfectant Eusol. The efficacy and safety of Eusol and other chloric acid (hypochlorous acid) derivatives in clinical use is debated.

Keywords

EarTemporal boneCarcinomaHypochoriteDisinfectantsCarcinogens
Type
Clinical Records
Information
The Journal of Laryngology & Otology , Volume 113 , Issue 11 , November 1999 , pp. 1004 - 1007
Copyright
Copyright © JLO (1984) Limited 1999

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Abdel-Rahman, M. S., Berardi, M. R., Bull, R. J. (1982) Effect of chlorine and monochloramine in drinking water on the developing rat foetus. Journal of Applied Toxicology 2: 156.Google Scholar
Applebaum, E. L. (1979) Radiation-induced carcinoma of the temporal bone. Otolaryngology – Head and Neck Surgery 87(5): 604–609.Google Scholar
Beal, D. D., Lindsay, J. R., Ward, P. H. (1965) Radiationinduced carcinoma of the mastoid. Archives of Otolaryngology – Head and Neck Surgery 81: 9–16.CrossRefGoogle ScholarPubMed
Bizgalis, A. R., Keith, A. O., Farrington, W. T. (1992) Radiotherapy in the treatment of middle ear and mastoid carcinoma. Clinical Otolaryngology and Allied Sciences 17(2): 113–116.CrossRefGoogle Scholar
Block, S. S. (1991) Historical review. In Disinfection, Sterilization and Preservation 4th Edition (Block, S. S., ed.) Lea and Febiger, Philadelphia, USA, p 3–17.Google Scholar
Brennan, S. S., Leaper, D. J. (1985) The effect of antiseptics on the healing wound: a study using the rabbit ear chamber. British Journal of Surgery 72: 780–782.CrossRefGoogle ScholarPubMed
British National Formulary (1998) Disinfectants and cleansers. British Medical Association and the Royal Pharmaceutical Society, London, In no 34, section 13: 11(4), p 504.Google Scholar
Center for Disease Control (1982) Acquired immune deficiency syndrome (AIDS): precautions for clinical and laboratory staffs. Morbidity and Mortality Weekly Report 31: 577–580.Google Scholar
Coachman, E. H. (1951) Squamous cell carcinoma secondary to cholesteatoma. Archives of Otolaryngology – Head and Neck Surgery 54: 187.Google Scholar
Conley, J. J., Novack, A. J. (1960) The surgical treatment of malignant tumours of the ear and temporal bone. Archives of Otolaryngology – Head and Neck Surgery 71: 635–652.Google Scholar
Cursons, R. T. M., Brown, T. J., Keys, E. A. (1980) Effect of disinfectants on pathogenic free-living amoebae: in axenic conditions. Applied Environmental Microbiology 40: 62–66.Google Scholar
Dakin, H. D. (1915) On the use of certain antiseptic substances in the treatment of infected wounds. British Medical Journal 2: 318–320.Google Scholar
Environmental Protection Agency Genetic Toxicology Programme (1983) Vol. 1, No. 8 and Vol. 3, No. 6 DPIM report.Google Scholar
Hasegawa, R., Takahashi, T., Kokubo, F., Furukawa, K., Toyoda, K., Sato, H., Kurokawa, Y., Hayashi, Y. (1986)Carcinogenicity study of sodium hypochlorite in F344 rats. Food and Chemicals Toxicology 24(12): 1295–1302.CrossRefGoogle ScholarPubMed
Hayatsu, H., Hoshino, H., Kawazoe, Y. (1979) Potential carcinogenicity of sodium hypochlorite. Nature 233: 495.Google Scholar
International Agency for Research on Cancer Working Group (1979) Some halogenated hydrocarbons. Monographs on the Evaluation of the Carcincogenic Risk of Chemicals to Humans. Vol. 20. International Agency for Research on Cancer, Lyon.Google Scholar
Issing, P. R., Kempf, H. G., Schonermark, M., Lenarz, T. (1995) Das Felsenbeinkarzinom-Aktuellediagostche and therapeutische Aspekte. Laryngo-Rhino-Otologie 74(11): 666–672.Google Scholar
Kawachi, T., Komatsu, T., Kada, T., Ishidate, M., Sasaki, M., Sugiyama, T., Tajima, Y. (1980) Results of recent studies on the relevance of various short-term screening tests in Japan. In The Predictive Value of Short-term Screening Tests in Carcinogenicity Evaluation. (Williams, G. M., Waaijers, H. W., van de Poll, K. W., eds.) Elsevier, Amsterdam, p 253.Google Scholar
Kurokawq, Y., Takayama, S., Konishi, Y., Hiasa, Y., Asahina, S., Takahashi, M., Maekawa, A., Hayashi, Y. (1986) Longterm in vivo carcinogenicity tests of potassium bromate, sodium hypochlorite and sodium chlorite conducted in Japan. Environmental Health Perspectives 69: 221–235.Google Scholar
Lewis, J. S. (1975) Temporal bone resection. Review of 100 cases. Archives of Otolaryngology – Head and Neck Surgery 101: 23–25.CrossRefGoogle ScholarPubMed
Lorrain-Smith, J., Drennan, A. M., Rettie, T., Campbell, W. (1915) Antiseptic action of hypochlorous acid and its application to wound treatment. British Medical Journal 2: 129–136.Google Scholar
Martindaie, (1996) The Extra Pharmacopoeia. 31st Edition. Royal Pharmaceutical Society Press, London, pp 1145 and 1680.Google Scholar
Michaels, L., Wells, M. (1980) Squamous cell carcinoma of the middle ear. Clinical Otolaryngology 5: 235–248.Google Scholar
Moffat, D. A., Chiossone, J. A., de Cruz, M. Ear canal. In Tumours of the Ear and Temporal Bone, (Jackler, R., Driscoll, C. eds.) Lippincott-Raven, (in press).Google Scholar
Moffat, D. A., Grey, P., Ballagh, R. H., Hardy, D. G. (1997) Extended temporal bone resection for squamous carcinoma. Otolaryngology – Head and Neck Surgery 116(6 pt 1): 617–623.CrossRefGoogle Scholar
Morgan, D. A. (1989) Chlorinated solutions: (E) useful or (e) useless? Pharmaceutical Journal 243: 219–220.Google Scholar
National Institute for Occupational Safety and Health (1985) Registry of Toxic Effects of Chemical Substances (Lewis, R. L. Sr., Sweet, D. V., eds.) Vol. 2 Entry No. NH3486300, p. 1044, NIOSH, Cincinnati, OH.Google Scholar
Olivieri, V. P., Dennis, W. H., Snead, M. C, Richfield, D. T., Kruse, C. W. (1978) Reaction of chlorine and chloramines with nucleic acids under disinfection conditions in water chlorination. Environmental Impact and Health Effects. Vol. 3. Ann Arbor, MI.Google Scholar
Resnick, L., Venen, K., Salahuddin, S. Z., Tondreau, S., Markham, P. D. (1986) Stability and inactivation of HTLVIII/LAV under clinical and laboratory environment. Journal of The American Medical Association 255: 1887–1891.Google Scholar
Ruben, R. J., Thaler, S. B., Holzer, N. (1997) Raidationinduced carcinoma of the temporal bone. Laryngoscope 87: 1613–1621.Google Scholar
Rutala, W. A., Weber, D. J. (1997) Uses of inorganic hypochlorite (bleach) in health-care facilities. Clinical Microbiology Reviews 10(4): 597–610Google Scholar
Sax, N. I., Lewis, R. J. (1989) Sax's Dangerous Properties of Industrial Materials. (7th ed. Vol. 3) Van Nostrand Reinnold Company, New York, NY pp. 1971–2 and 3072.Google Scholar
Shaheen, O. H. (1997) Epithelial tumours of the external auditory meatus and the middle ear. In Scott Brown's Otolaryngology, Vol. 3. (Kerr, A. G., ed.) Butterworth-Heinemann, Bath, p. 1.Google Scholar
Sykes, G. (1970) The sporicidal properties of chemical disinfectants. Journal of Applied Bacteriology 33: 147–156.CrossRefGoogle ScholarPubMed
Whitmore, T. N., Denny, S. (1992) The effect of disinfectants on a geosmin-producing strain of Streptomyces griesus. Journal of Applied Bacteriology 72: 160–165.Google Scholar