Hostname: page-component-586b7cd67f-dlnhk Total loading time: 0 Render date: 2024-11-26T12:15:12.342Z Has data issue: false hasContentIssue false
  • English
  • Français

Bacterial lysate for the prevention of chronic rhinosinusitis recurrence in children

Published online by Cambridge University Press:  20 March 2017

J Chen ,
Y Zhou ,
J Nie ,
Y Wang ,
L Zhang ,
Q Shi ,
H Tan  and
W Kong
J Chen
Affiliation:
Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Y Zhou
Affiliation:
Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
J Nie
Affiliation:
Department of Endocrinology, Third Affiliate Hospital of Guangzhou Medical University, Guang Zhou, China
Y Wang
Affiliation:
Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
L Zhang
Affiliation:
Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Q Shi
Affiliation:
Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
H Tan
Affiliation:
Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
W Kong*
Affiliation:
Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
*
Address for correspondence: Dr Weijia Kong, Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China Fax: +86 27 8572 7712 E-mail: [email protected]
Get access Rights & Permissions [Opens in a new window]

Abstract

Background:

Chronic rhinosinusitis is a common nasal disorder in children that is prone to recurrence. This study investigated the prevention of chronic rhinosinusitis recurrence with bacteria lysate in children.

Methods:

Bacteria lysate was administered 10 days per month for 3 months to children with chronic rhinosinusitis, who had just entered a remission phase. Visual analogue score, nasal symptoms scores, rhinitis attack frequency and antibiotic use were assessed at three months and one year.

Results:

At one year of follow up, the visual analogue score, nasal discharge and obstruction scores, number of days with rhinitis attacks per month and number of days with antibiotic use per month were significantly decreased in the prevention group versus the control group (p < 0.05).

Conclusion:

Bacterial lysate used in the remission period of rhinosinusitis in children was shown to provide long-term prophylaxis. Bacterial lysate can effectively reduce the frequency of rhinosinusitis attacks and ameliorate attack symptoms.

Keywords

SinusitisTertiary PreventionChildren
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 131 , Issue 6 , June 2017 , pp. 523 - 528
Copyright
Copyright © JLO (1984) Limited 2017 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1 Shi, JB, Fu, QL, Zhang, H, Cheng, L, Wang, YJ, Zhu, DD et al. Epidemiology of chronic rhinosinusitis: results from a cross-sectional survey in seven Chinese cities. Allergy 2015;70:533–9Google Scholar
2 Fokkens, WJ, Lund, VJ, Mullol, J, Bachert, C, Alobid, I, Baroody, F et al. European Position Paper on Rhinosinusitis and Nasal Polyps 2012. Rhinol Suppl 2012;23:1–298 Google Scholar
3 Manning, SC. Pediatric sinusitis. Otolaryngol Clin North Am 1993;26:623–38Google Scholar
4 Albegger, K. ENT aspects of rhino-sinusitis in children (author's transl) [in German]. HNO 1980;28:321–8Google Scholar
5 De Benedetto, F, Sevieri, G. Prevention of respiratory tract infections with bacterial lysate OM-85 bronchomunal in children and adults: a state of the art. Multidiscip Respir Med 2013;8:33 Google Scholar
6 Ahrens, J. A double blind multicentre trial with BRONCHO-VAXOM in adults. Atemwegs- und Lungenkrankheite 1983;9:424–7Google Scholar
7 Carmona-Ramirez, M A, Alvarez-Gomez, V, Berber, A. Use of OM-85 BV for the prevention of acute respiratory tract infections in occupational medicine. J Int Med Res 2002;30:325–9Google Scholar
8 Heintz, B, Schlenter, WW, Kirsten, R, Nelson, K. Clinical efficacy of Broncho-Vaxom in adult patients with chronic purulent sinusitis–a multi-centric, placebo-controlled, double-blind study. Int J Clin Pharmacol Ther Toxicol 1989;27:530–4Google ScholarPubMed
9 Zagar, S, Löfler-Badzek, D. Broncho-Vaxom in children with rhinosinusitis: a double-blind clinical trial. ORL J Otorhinolaryngol Relat Spec 1988;50:397–404 Google Scholar
10 Cvoriscec, B, Ustar, M, Pardon, R, Palecek, I, Stipic-Markovic, A, Zimic, B. Oral immunotherapy of chronic bronchitis: a double-blind placebo-controlled multicentre study. Respiration 1989;55:129–35Google Scholar
11 Orcel, B, Delclaux, B, Baud, M, Derenne, JP. Oral immunization with bacterial extracts for protection against acute bronchitis in elderly institutionalized patients with chronic bronchitis. Eur Respir J 1994;7:446–52Google Scholar
12 Pan, L, Jiang, XG, Guo, J, Tian, Y, Liu, CT. Effects of OM-85 BV in patients with chronic obstructive pulmonary disease: a systematic review and meta-analysis. J Clin Pharmacol 2015;55:1086–92Google Scholar
13 Sedaghat, AR, Phipatanakul, W, Cunningham, MJ. Prevalence of and associations with allergic rhinitis in children with chronic rhinosinusitis. Int J Pediatr Otorhinolaryngol 2014;78:343–7Google Scholar