Hostname: page-component-cd9895bd7-jn8rn Total loading time: 0 Render date: 2024-12-24T01:30:48.955Z Has data issue: false hasContentIssue false
  • English
  • Français

Are laryngeal squamous cell carcinoma incidence and patient mortality a function of ABO blood grouping? A retrospective study

Published online by Cambridge University Press:  10 October 2011

S I Adam ,
K M Wilson ,
S M Overholser ,
E Khabbaz ,
K Moreno  and
Y J Patil
S I Adam
Affiliation:
Department of Otolaryngology-Head and Neck Surgery, Brain Tumor Center, University of Cincinnati Neuroscience Institute and University of Cincinnati College of Medicine, Ohio, USA
K M Wilson*
Affiliation:
Department of Otolaryngology-Head and Neck Surgery, Brain Tumor Center, University of Cincinnati Neuroscience Institute and University of Cincinnati College of Medicine, Ohio, USA
S M Overholser
Affiliation:
Department of Otolaryngology-Head and Neck Surgery, Brain Tumor Center, University of Cincinnati Neuroscience Institute and University of Cincinnati College of Medicine, Ohio, USA
E Khabbaz
Affiliation:
Department of Otolaryngology-Head and Neck Surgery, Brain Tumor Center, University of Cincinnati Neuroscience Institute and University of Cincinnati College of Medicine, Ohio, USA
K Moreno
Affiliation:
Department of Otolaryngology-Head and Neck Surgery, Brain Tumor Center, University of Cincinnati Neuroscience Institute and University of Cincinnati College of Medicine, Ohio, USA
Y J Patil
Affiliation:
Department of Otolaryngology-Head and Neck Surgery, Brain Tumor Center, University of Cincinnati Neuroscience Institute and University of Cincinnati College of Medicine, Ohio, USA
*
Address for correspondence: Dr Keith Wilson, c/o Editorial Office, University of Cincinnati Neuroscience Institute, UC College of Medicine, PO Box 670515, Cincinnati, OH 45267-0515, USA Fax: +1 513 558 7702 E-mail: [email protected]
Get access Rights & Permissions [Opens in a new window]

Abstract

Objective:

Few studies have examined the association between ABO blood grouping and head and neck cancer. This retrospective review examined the association between blood group and laryngeal cancer incidence and patient mortality.

Methods:

Of 271 patients treated for squamous cell laryngeal carcinoma (1997–2002), 143 patients with supraglottic, glottic and subglottic tumours were included; 128 patients were excluded. The blood group characteristics of patients and healthy blood donors were compared.

Results:

There was no significant correlation between blood type and laryngeal carcinoma incidence or mortality. Type A blood was commoner in African Americans with laryngeal cancer than Caucasian patients, but not significantly so. As expected, five-year survival rates were lower in patients with more advanced stage cancer (p < 0.0001).

Conclusion:

Although our findings show no association between blood group and five-year survival, these results are inconclusive, and warrant further study of the association between blood type and laryngeal (and other) head and neck cancers.

Keywords

Larynx NeoplasmsABO Blood Group SystemCarcinomaPrognosisSurvival
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 126 , Issue 2 , February 2012 , pp. 180 - 184
Copyright
Copyright © JLO (1984) Limited 2011

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1Reiddy, PM, Dedo, HH, Rabah, R, Field, JB, Mathog, RH, Gregoire, L et al. Integration of human papillomavirus type 11 in recurrent respiratory papilloma-associated cancer. Laryngoscope 2004;114:1906–9CrossRefGoogle Scholar
2Su, M, Lu, SM, Tian, DP, Zhao, H, Li, XY, Li, DR et al. Relationship between ABO blood groups and carcinoma of esophagus and cardia in Chaosan inhabitants of China. World J Gastroenterol 2001;7:657–61CrossRefGoogle Scholar
3Tursen, U, Tiftik, N, Unal, S, Gunduz, O, Kaya, TI, Camdiviren, H et al. Relationship between ABO blood groups and skin cancers. Derm Online J 2005;11:44Google ScholarPubMed
4Dabelsteen, E. Cell surface carbohydrates as prognostic markers in human carcinomas. J Pathol 1996;179:358–693.0.CO;2-T>CrossRefGoogle ScholarPubMed
5Celestino, D, Silvagni, C. On the distribution of blood groups of ABO system in individuals with laryngeal carcinoma. Valsalva 1964;40:211–16Google ScholarPubMed
6Nowinska, E, Namyslowski, G, Scierski, W, Kocierz, S. ABO blood groups in patients with laryngeal cancer (in Polish). Otolaryngol Pol 2000;54(suppl 31):209–11Google Scholar
7Office of Rare Diseases National Institutes of Health Department of Health and Human Services. Annual Report on the Rare Diseases and Conditions Research. Bethesda, Maryland: National Institutes of Health, 2006Google Scholar
8Anderson, DE, Haas, C. Blood type A and familial breast cancer. Cancer 1984;54:1845–93.0.CO;2-5>CrossRefGoogle ScholarPubMed
9Pinkston, JA, Cole, P. ABO blood groups and salivary gland tumors (Alabama, United States). Cancer Causes Control 1996;7:572–4CrossRefGoogle ScholarPubMed
10Moldvay, J, Scheid, P, Wild, P, Nabil, K, Siat, J, Borrelly, J et al. Predictive survival markers in patients with surgically resected non-small cell lung carcinoma. Clin Cancer Res 2000;6:1125–34Google ScholarPubMed
11Ichikawa, D, Handa, K, Hakomori, S. Histo-blood group A/B antigen deletion/reduction vs. continuous expression in human tumor cells as correlated with their malignancy. Int J Cancer 1998;76:284–93.0.CO;2-C>CrossRefGoogle Scholar