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The anti-inflammatory effects of erythromycin, clarithromycin, azithromycin and roxithromycin on histamine-induced otitis media with effusion in guinea pigs

Published online by Cambridge University Press:  11 June 2018

B Ersoy ,
B Aktan ,
K Kilic ,
M S Sakat  and
S Sipal
B Ersoy
Affiliation:
Department of Otolaryngology, City Hospital, Mersin, Turkey
B Aktan
Affiliation:
Department of Otolaryngology, Faculty of Medicine, Atatürk University, Erzurum, Turkey
K Kilic*
Affiliation:
Department of Otolaryngology, Regional Training and Research Hospital, Erzurum, Turkey
M S Sakat
Affiliation:
Department of Otolaryngology, Faculty of Medicine, Atatürk University, Erzurum, Turkey
S Sipal
Affiliation:
Department of Pathology, Faculty of Medicine, Atatürk University, Erzurum, Turkey
*
Address for correspondence: Dr Korhan Kilic, Department of Otolaryngology, Regional Training and Research Hospital, Erzurum, Turkey E-mail: [email protected]
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Abstract

Background

Otitis media with effusion is a clinical manifestation characterised by inflammation of middle-ear mucosa. This study investigated the therapeutic effect of erythromycin, clarithromycin, azithromycin and roxithromycin on a histamine-induced animal model of otitis media with effusion.

Methods

The animals were divided into five groups, receiving erythromycin, clarithromycin, azithromycin, roxithromycin or saline solution. The guinea pigs in the study groups received erythromycin (40 mg/kg/day), clarithromycin (15 mg/kg/day), azithromycin (10 mg/kg/day) or roxithromycin (10 mg/kg/day) for 3 days by gastric tube. Four hours after the end of the administration, histamine solution was injected into the right middle ear.

Results

The lowest neutrophil density value obtained using stereological techniques was in the azithromycin group (0.86 ± 0.25 × 10−5/μm3), while the highest value was observed in the control group (6.68 ± 3.12 × 10−5/μm3). The anti-inflammatory properties of clarithromycin, azithromycin and roxithromycin were similar to one another, but better than that of erythromycin.

Conclusion

The use of macrolide antibiotics is recommended, as they show antibacterial and anti-inflammatory efficacy in otitis media with effusion.

Keywords

Otitis Media With EffusionErythromycinClarithromycinAzithromycinRoxithromycin
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 132 , Issue 7 , July 2018 , pp. 579 - 583
Copyright
Copyright © JLO (1984) Limited, 2018 

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Footnotes

Dr K Kilic takes responsibility for the integrity of the content of the paper

References

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