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Anti-inflammatory effect of erythromycin on histamine-induced otitis media with effusion in guinea pigs

Published online by Cambridge University Press:  08 March 2006

Bülent Aktan ,
Cemal Gundogdu ,
Harun Ucuncu ,
Bunyami Unal ,
Yavuz Sütbeyaz  and
Sare Altas
Bülent Aktan
Affiliation:
Department of Otorhinolaryngology-Head and Neck Surgery, Atatürk University, School of Medicine, Erzurum, Turkey
Cemal Gundogdu
Affiliation:
Department of Pathology, Atatürk University, School of Medicine, Erzurum, Turkey
Harun Ucuncu
Affiliation:
Department of Otorhinolaryngology-Head and Neck Surgery, Atatürk University, School of Medicine, Erzurum, Turkey
Bunyami Unal
Affiliation:
Department of Histology, Atatürk University, School of Medicine, Erzurum, Turkey
Yavuz Sütbeyaz
Affiliation:
Department of Otorhinolaryngology-Head and Neck Surgery, Atatürk University, School of Medicine, Erzurum, Turkey
Sare Altas
Affiliation:
Department of Pathology, Atatürk University, School of Medicine, Erzurum, Turkey
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Abstract

In this study, the anti-inflammatory effect of erythromycin was investigated in a model of histamine-induced otitis media with effusion (OME). OME was induced in guinea pigs by the transtympanic injection of histamine solution into the middle-ear cavity. Guinea pigs were randomly assigned to one of three groups: control, erythromycin treatment, or methylprednisolone treatment. After histamine injection, the animals were treated with intraperitoneal medication for five days consecutively. Afterwards, the animals were sacrificed and the temporal bones were removed. The samples were examined stereologically.

In the erythromycin-treated group, it was observed that neutrophil infiltration was significantly inhibited when compared to the control group. This result shows that erythromycin may produce a significant anti-inflammatory effect in this model of OME.

Keywords

OTitis Media with EffusionErythromycinGuinea Pigs
Type
Research Article
Information
The Journal of Laryngology & Otology , Volume 118 , Issue 2 , February 2004 , pp. 97 - 101
Copyright
© Royal Society of Medicine Press Limited 2004

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